Novel Objective Measures of Hypersomnolence.

IF 1.5 Q4 CLINICAL NEUROLOGY Current Sleep Medicine Reports Pub Date : 2023-03-01 Epub Date: 2023-01-10 DOI:10.1007/s40675-022-00245-2

Alex Dworetz, Lynn Marie Trotti, Surina Sharma

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Abstract

Purpose of review: To provide a brief overview of current objective measures of hypersomnolence, discuss proposed measure modifications, and review emerging measures.

Recent findings: There is potential to optimize current tools using novel metrics. High-density and quantitative EEG-based measures may provide discriminative informative. Cognitive testing may quantify cognitive dysfunction common to hypersomnia disorders, particularly in attention, and objectively measure pathologic sleep inertia. Structural and functional neuroimaging studies in narcolepsy type 1 have shown considerable variability but so far implicate both hypothalamic and extra-hypothalamic regions; fewer studies of other CDH have been performed. There is recent renewed interest in pupillometry as a measure of alertness in the evaluation of hypersomnolence.

Summary: No single test captures the full spectrum of disorders and use of multiple measures will likely improve diagnostic precision. Research is needed to identify novel measures and disease-specific biomarkers, and to define combinations of measures optimal for CDH diagnosis.

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嗜睡的新的客观测量方法。

审查目的：简要概述目前嗜睡的客观指标，讨论拟议的指标修改，并审查新出现的指标。最近的发现：有可能使用新的指标来优化当前的工具。基于高密度和定量EEG的测量可以提供有区别的信息。认知测试可以量化睡眠过度障碍常见的认知功能障碍，特别是在注意力方面，并客观地测量病理性睡眠惯性。1型发作性睡病的结构和功能神经影像学研究显示出相当大的可变性，但迄今为止涉及下丘脑和下丘脑外区域；对其他CDH的研究较少。最近，人们对瞳孔测量作为评估嗜睡的警觉性指标重新产生了兴趣。总结：没有一种单一的测试可以捕捉到全方位的疾病，使用多种测量方法可能会提高诊断精度。需要进行研究，以确定新的测量方法和疾病特异性生物标志物，并确定CDH诊断的最佳测量方法组合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Sleep Medicine Reports Medicine-Pulmonary and Respiratory Medicine

CiteScore

2.50

自引率

5.60%

发文量

期刊介绍： Current Sleep Medicine Reports aims to review the most important, recently published articles in the field of sleep medicine. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of sleep conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as insomnia, narcolepsy, sleep apnea, circadian rhythm disorders, and parasomnias. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.