Pub Date : 2025-01-01Epub Date: 2025-02-17DOI: 10.1007/s40675-025-00325-z
Gabrielle F Gloston, Katherine C Ward, G Carolina Rodriguez-Torres, Karen L Gamble, S Justin Thomas
Purpose of review: Despite advancements in basic circadian research, development of new diagnostic and treatment strategies for circadian rhythm sleep-wake disorders (CRSWDs) has been slow. Here, we review the most recent innovations in human circadian assessment and emerging new therapies for CRSWDs.
Recent findings: Researchers have improved existing circadian assessment methods to overcome logistical barriers and developed novel circadian assessment methods. New treatments for CRSWDs involve pharmacological and behavioral treatments that modulate circadian phase, amplitude, and/or robustness of the central circadian clock.
Summary: Commercialization of these emerging tools will require overcoming barriers, such as additional testing to confirm the underlying pathology and mechanism of action of potential treatments. Clinicians and scientists are also called to survey adjacent fields and adopt existing diagnostic tools that may offer diagnostic clarity in CRSWDs. Lastly, we must continue to advocate for medical insurance coverage of current and future tools and technologies to improve patient care.
{"title":"Integrating Assessment of Circadian Rhythmicity to Improve Treatment Outcomes for Circadian Rhythm Sleep-Wake Disorders: Updates on New Treatments.","authors":"Gabrielle F Gloston, Katherine C Ward, G Carolina Rodriguez-Torres, Karen L Gamble, S Justin Thomas","doi":"10.1007/s40675-025-00325-z","DOIUrl":"10.1007/s40675-025-00325-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>Despite advancements in basic circadian research, development of new diagnostic and treatment strategies for circadian rhythm sleep-wake disorders (CRSWDs) has been slow. Here, we review the most recent innovations in human circadian assessment and emerging new therapies for CRSWDs.</p><p><strong>Recent findings: </strong>Researchers have improved existing circadian assessment methods to overcome logistical barriers and developed novel circadian assessment methods. New treatments for CRSWDs involve pharmacological and behavioral treatments that modulate circadian phase, amplitude, and/or robustness of the central circadian clock.</p><p><strong>Summary: </strong>Commercialization of these emerging tools will require overcoming barriers, such as additional testing to confirm the underlying pathology and mechanism of action of potential treatments. Clinicians and scientists are also called to survey adjacent fields and adopt existing diagnostic tools that may offer diagnostic clarity in CRSWDs. Lastly, we must continue to advocate for medical insurance coverage of current and future tools and technologies to improve patient care.</p>","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"11 1","pages":"8"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-06-24DOI: 10.1007/s40675-024-00308-6
Sanjana Agarwal, Paige Monsod, Yoon-Sik Cho, Sharon MacRae, Justyna S Swierz, William J Healy, Younghoon Kwon, Xiaoyue Liu, Yeilim Cho
Purpose of review: Racial disparities in sleep health as well as the diagnosis and treatment of sleep disorders have emerged as a key driver of cardiovascular outcomes. Obstructive sleep apnea (OSA), is characterized by repeated airway obstructions during sleep and is associated with an increased risk of cardiovascular disease. While racial and ethnic minorities have disproportionately high OSA prevalence rates, diagnosis rates remain low. One explanation behind this phenomenon are structural environmental and lifestyle barriers that prevent access to OSA care. Additionally, there remains significantly limited understanding of OSA and its causes and symptoms within communities.
Recent findings: In general, minorities have poorer sleep health due to systemic and environmental racism, which also causes an increased in conditions such as obesity that increases OSA risk. Disparities also persist within various types of OSA treatment. The most common form of treatment, continuous positive airway pressure (CPAP) has lower adherence among African Americans, as well as those living in areas with low socioeconomic status (SES), primarily minorities. There have been a small number of studies that have shown some initial success of educational campaigns about OSA within minority communities in increasing screenings and diagnoses. Peer based education has been an effective technique, and there is a need for such programs to be expanded.
Summary: Disparities persist, with minority groups having worse sleep health and lower rates of adherence to OSA treatment. Some grassroots, peer-led educational campaigns show promise in increasing adherence. In light of these disparities, there remains a need for the field of sleep medicine to continue addressing the systemic barriers that hinder the timely evaluation and treatment in racial minorities.
综述目的：睡眠健康以及睡眠障碍的诊断和治疗方面的种族差异已成为心血管疾病的一个主要驱动因素。阻塞性睡眠呼吸暂停（OSA）的特点是睡眠时反复出现气道阻塞，与心血管疾病风险增加有关。虽然少数种族和少数族裔的 OSA 患病率过高，但诊断率仍然很低。造成这种现象的原因之一是结构性的环境和生活方式障碍，它们阻碍了人们获得 OSA 治疗。此外，各社区对 OSA 及其原因和症状的了解仍然非常有限：总体而言，由于系统性和环境性的种族主义，少数族裔的睡眠健康状况较差，这也导致肥胖等增加 OSA 风险的病症增多。各种类型的 OSA 治疗也存在差异。最常见的治疗方式是持续气道正压（CPAP），但非裔美国人以及生活在社会经济地位（SES）较低地区的人，主要是少数族裔，对 CPAP 的依从性较低。有少量研究表明，在少数族裔社区开展有关 OSA 的教育活动在增加筛查和诊断方面取得了初步成效。基于同伴的教育是一种有效的方法，有必要扩大此类计划的范围。摘要：差异依然存在，少数群体的睡眠健康状况较差，坚持 OSA 治疗的比例较低。一些基层的、由同龄人主导的教育活动显示出提高坚持治疗率的希望。鉴于这些差异，睡眠医学领域仍需继续解决阻碍对少数族裔进行及时评估和治疗的系统性障碍。
{"title":"Racial Disparity in Obstructive Sleep Apnea Care and its Impact on Cardiovascular Health.","authors":"Sanjana Agarwal, Paige Monsod, Yoon-Sik Cho, Sharon MacRae, Justyna S Swierz, William J Healy, Younghoon Kwon, Xiaoyue Liu, Yeilim Cho","doi":"10.1007/s40675-024-00308-6","DOIUrl":"10.1007/s40675-024-00308-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>Racial disparities in sleep health as well as the diagnosis and treatment of sleep disorders have emerged as a key driver of cardiovascular outcomes. Obstructive sleep apnea (OSA), is characterized by repeated airway obstructions during sleep and is associated with an increased risk of cardiovascular disease. While racial and ethnic minorities have disproportionately high OSA prevalence rates, diagnosis rates remain low. One explanation behind this phenomenon are structural environmental and lifestyle barriers that prevent access to OSA care. Additionally, there remains significantly limited understanding of OSA and its causes and symptoms within communities.</p><p><strong>Recent findings: </strong>In general, minorities have poorer sleep health due to systemic and environmental racism, which also causes an increased in conditions such as obesity that increases OSA risk. Disparities also persist within various types of OSA treatment. The most common form of treatment, continuous positive airway pressure (CPAP) has lower adherence among African Americans, as well as those living in areas with low socioeconomic status (SES), primarily minorities. There have been a small number of studies that have shown some initial success of educational campaigns about OSA within minority communities in increasing screenings and diagnoses. Peer based education has been an effective technique, and there is a need for such programs to be expanded.</p><p><strong>Summary: </strong>Disparities persist, with minority groups having worse sleep health and lower rates of adherence to OSA treatment. Some grassroots, peer-led educational campaigns show promise in increasing adherence. In light of these disparities, there remains a need for the field of sleep medicine to continue addressing the systemic barriers that hinder the timely evaluation and treatment in racial minorities.</p>","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"10 4","pages":"414-418"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-02DOI: 10.1007/s40675-023-00272-7
Stuti J. Jaiswal, Jeff B. Pawelek, Shiri Warshawsky, Giorgio Quer, Megan Trieu, Jay A. Pandit, Robert L. Owens
{"title":"Using New Technologies and Wearables for Characterizing Sleep in Population-based Studies","authors":"Stuti J. Jaiswal, Jeff B. Pawelek, Shiri Warshawsky, Giorgio Quer, Megan Trieu, Jay A. Pandit, Robert L. Owens","doi":"10.1007/s40675-023-00272-7","DOIUrl":"https://doi.org/10.1007/s40675-023-00272-7","url":null,"abstract":"","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"10 3","pages":"1-11"},"PeriodicalIF":1.8,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139124817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-22DOI: 10.1007/s40675-023-00270-9
Sydneyjane Roberts, C. Ulmer
{"title":"Barriers in Access to and Delivery of Behavioral Sleep Treatments","authors":"Sydneyjane Roberts, C. Ulmer","doi":"10.1007/s40675-023-00270-9","DOIUrl":"https://doi.org/10.1007/s40675-023-00270-9","url":null,"abstract":"","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"11 20","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138944447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-20DOI: 10.1007/s40675-023-00271-8
Jaime M. Hughes
{"title":"Expanding Access to CBT-I for Older Adults: Review and Expansion of Recent Recommendations","authors":"Jaime M. Hughes","doi":"10.1007/s40675-023-00271-8","DOIUrl":"https://doi.org/10.1007/s40675-023-00271-8","url":null,"abstract":"","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"95 24","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138954170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-24DOI: 10.1007/s40675-023-00269-2
Habibolah Khazaie, Saeid Komasi, Reena Mehra, Sepideh Khazaie, A. Alipourian, Vijay Nambi, Amir Sharafkhaneh
{"title":"Insomnia and Incidence of Heart Failure in a Sample of Half a Million People: a Meta-analytic Review and Meta-regression of Prospective Studies","authors":"Habibolah Khazaie, Saeid Komasi, Reena Mehra, Sepideh Khazaie, A. Alipourian, Vijay Nambi, Amir Sharafkhaneh","doi":"10.1007/s40675-023-00269-2","DOIUrl":"https://doi.org/10.1007/s40675-023-00269-2","url":null,"abstract":"","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"25 1","pages":"281-295"},"PeriodicalIF":1.8,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139238683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-09DOI: 10.1007/s40675-023-00268-3
Christina S. McCrae, Ashley F. Curtis, Melanie A. Stearns, Jason G. Craggs
{"title":"Fibromyalgia and the Brain: What’s Sleep got to do with it?","authors":"Christina S. McCrae, Ashley F. Curtis, Melanie A. Stearns, Jason G. Craggs","doi":"10.1007/s40675-023-00268-3","DOIUrl":"https://doi.org/10.1007/s40675-023-00268-3","url":null,"abstract":"","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":" 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135241719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-31DOI: 10.1007/s40675-023-00267-4
Chenlu Gao, Shahab Haghayegh, Max Wagner, Ruixue Cai, Kun Hu, Lei Gao, Peng Li
Abstract Purpose of Review To review methods for analyzing circadian rest-activity patterns using actigraphy and to discuss their applications in large cohort and population-based studies. Recent Findings We reviewed several widely used approaches, including parametric analysis (i.e., cosinor model and wavelet analysis), nonparametric analysis, data adaptive approach (i.e., empirical mode decomposition), and nonlinear dynamical approach (i.e., fractal analysis). We delved into the specifics of each approach and highlighted their advantages and disadvantages. Summary Various approaches have been developed to study circadian rest-activity rhythms using actigraphy. Features extracted from these approaches have been associated with population health outcomes. Limitations exist in prior research, including inconsistencies due to various available analytical approaches and lack of studies translating findings to the context of the circadian system. Potential future steps are proposed. The review ends with an introduction to an open-source software application— ezActi2 —developed to facilitate scalable applications in analyzing circadian rest-activity rhythms.
{"title":"Approaches for Assessing Circadian Rest-Activity Patterns Using Actigraphy in Cohort and Population-Based Studies","authors":"Chenlu Gao, Shahab Haghayegh, Max Wagner, Ruixue Cai, Kun Hu, Lei Gao, Peng Li","doi":"10.1007/s40675-023-00267-4","DOIUrl":"https://doi.org/10.1007/s40675-023-00267-4","url":null,"abstract":"Abstract Purpose of Review To review methods for analyzing circadian rest-activity patterns using actigraphy and to discuss their applications in large cohort and population-based studies. Recent Findings We reviewed several widely used approaches, including parametric analysis (i.e., cosinor model and wavelet analysis), nonparametric analysis, data adaptive approach (i.e., empirical mode decomposition), and nonlinear dynamical approach (i.e., fractal analysis). We delved into the specifics of each approach and highlighted their advantages and disadvantages. Summary Various approaches have been developed to study circadian rest-activity rhythms using actigraphy. Features extracted from these approaches have been associated with population health outcomes. Limitations exist in prior research, including inconsistencies due to various available analytical approaches and lack of studies translating findings to the context of the circadian system. Potential future steps are proposed. The review ends with an introduction to an open-source software application— ezActi2 —developed to facilitate scalable applications in analyzing circadian rest-activity rhythms.","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135871395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-12DOI: 10.1007/s40675-023-00265-6
Luke J. Klugherz, Bhanu Prakash Kolla, Meghna P. Mansukhani
{"title":"Pharmacological Treatments for Insomnia","authors":"Luke J. Klugherz, Bhanu Prakash Kolla, Meghna P. Mansukhani","doi":"10.1007/s40675-023-00265-6","DOIUrl":"https://doi.org/10.1007/s40675-023-00265-6","url":null,"abstract":"","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135878592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.1007/s40675-023-00266-5
C. Kwee, L. M. Dos Santos
{"title":"The Relationships Between Sleep Disorders, Burnout, Stress and Coping Strategies of Health Professionals During the COVID-19 Pandemic: a Literature Review","authors":"C. Kwee, L. M. Dos Santos","doi":"10.1007/s40675-023-00266-5","DOIUrl":"https://doi.org/10.1007/s40675-023-00266-5","url":null,"abstract":"","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49432087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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