Prevalence of cutaneous Leishmaniasis in the Middle East: a systematic review and meta-analysis.

IF 4.9 4区 医学 Q1 PARASITOLOGY Pathogens and Global Health Pub Date : 2023-06-01 Epub Date: 2022-10-12 DOI:10.1080/20477724.2022.2133452
Mohsen Karami, Tahmineh Gorgani-Firouzjaee, Mohammad Chehrazi
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Abstract

Cutaneous leishmaniasis (CL), caused by an obligate intracellular protozoan parasite from the genus Leishmania, imposing a significant burden on underdeveloped countries especially those located in the Middle East. Four electronic databases were searched to evaluate the prevalence of CL in the Middle East. The random effects model (95% confidence intervals (CI)) were applied to determine the overall and subgroup pooled prevalence. Heterogeneity was assessed by Cochran's Q test and I2 statistics. Among 2424 peer-reviewed papers, 37 datasets from 34 studies were included in the current meta-analysis. 285560 individuals were assessed across 9 Middle Eastern countries. The pooled prevalence of CL was estimated at 12% (95% CI 9-15 %; 10718/285560). The highest prevalence rate was observed in Syria (39%, 37-42%), and the lowest one was found in Iraq and Lebanon (0%, 0-1%). The prevalence of CL in studies that applied LST assays had the highest rate (48%, 17-80%). The infection rate in males was similar to females (7%, 4-10%). The prevalence of infection in individuals living in urban areas was higher than in rural areas (14%, 10-19%). The prevalence of CL in the age group 0-15 years was higher than in individuals 16-40 and >40 years (9%, 6-13%). Most of the lesions were found on the face, and single lesions were more prevalent than two and three ones. In conclusion, the occurrence of CL was considerable in Middle Eastern countries. Therefore, more efforts should be made to precisely report the CL in this region for developing appropriate preventive and controlling strategies.  .

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中东地区皮肤利什曼病的患病率:一项系统综述和荟萃分析。
皮肤利什曼病(CL),由利什曼原虫属的一种专性细胞内原生动物寄生虫引起,给欠发达国家,尤其是中东地区的欠发达国家带来了巨大负担。检索了四个电子数据库,以评估CL在中东的流行情况。应用随机效应模型(95%置信区间(CI))来确定总体和亚组合并患病率。通过Cochran的Q检验和I2统计来评估异质性。在2424篇同行评审论文中,来自34项研究的37个数据集被纳入当前的荟萃分析。对9个中东国家的285560人进行了评估。CL的合并患病率估计为12%(95%置信区间9-15%;10718/285560)。叙利亚的患病率最高(39%,37-42%),伊拉克和黎巴嫩的患病率最低(0%,0-1%)。应用LST测定的研究中CL的患病率最高(48%,17-80%)。男性的感染率与女性相似(7%,4-10%)。城市地区的感染率高于农村地区(14%,10-19%)。0-15岁年龄组的CL患病率高于16-40岁和>40岁年龄组(9%,6-13%)。大多数病变发生在面部,单个病变比两个和三个病变更常见。总之,CL在中东国家的发生率相当高。因此,应做出更多努力,准确报告该地区的CL,以制定适当的预防和控制策略。  .
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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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