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Dengue virus infection in Saudi Arabia from 2003 to 2023: a systematic review and meta-analysis. 2003 年至 2023 年沙特阿拉伯的登革热病毒感染情况:系统回顾和荟萃分析。
IF 4.9 4区 医学 Q1 PARASITOLOGY Pub Date : 2024-11-07 DOI: 10.1080/20477724.2024.2425493
Ali A Rabaan, Amer Alshengeti, Hayam A Alrasheed, Maha F Al-Subaie, Maha H Aljohani, Yahya A Almutawif, Amjad A Yousuf, Shahab A Alsuliman, Jumana M Al-Jishi, Fareed Almalki, Maha A Alshiekheid, Hejji E Alahmed, Ameen M Alramadan, Safaa Abdulrahman Turkistani, Khalid Hajissa

Dengue virus (DENV) remains one of the most common arboviral infections threatening humans. This study was conducted to systematically review the available literature and provide an updated overview of the overall prevalence of DENV infection in Saudi Arabia. The prevalence data was pooled from 21,891 participants recruited in 17 studies. Using random-effects model, the overall prevalence of DENV infection in Saudi Arabia was calculated as 30.8% (95% CI: 20.8-49.8%). The pooled IgM and IgG seroprevalence rates were 17.7% and 26.6%, respectively. Furthermore, the detection of DENV-NS1 antigen and viral RNA revealed pooled estimates of 16.4% and 37.0%, respectively. This study reports a relatively high burden of DENV infection in Saudi Arabia. The findings of this SRMA provide valuable information on the epidemiology of DENV infections in the country, highlighting the need for additional epidemiological investigations to assess the current situation of DENV infection in the country.

登革热病毒(DENV)仍然是威胁人类的最常见虫媒病毒感染之一。本研究对现有文献进行了系统回顾,并提供了沙特阿拉伯登革热病毒感染总体流行率的最新概况。流行率数据来自 17 项研究招募的 21,891 名参与者。采用随机效应模型计算得出,沙特阿拉伯的 DENV 感染总流行率为 30.8%(95% CI:20.8-49.8%)。汇总的 IgM 和 IgG 血清流行率分别为 17.7% 和 26.6%。此外,DENV-NS1 抗原和病毒 RNA 的检测结果显示,综合估计值分别为 16.4% 和 37.0%。这项研究报告了沙特阿拉伯较高的 DENV 感染负担。该SRMA的研究结果为该国的DENV感染流行病学提供了有价值的信息,凸显了进行更多流行病学调查以评估该国DENV感染现状的必要性。
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引用次数: 0
Clinical applications of immunoglobulin G against different individual Aspergillus species for the diagnosis of chronic pulmonary aspergillosis among at-risk populations. 针对不同曲霉菌种的免疫球蛋白 G 在诊断高危人群慢性肺曲霉菌病中的临床应用。
IF 4.9 4区 医学 Q1 PARASITOLOGY Pub Date : 2024-11-06 DOI: 10.1080/20477724.2024.2424489
Li-Ta Keng, Chen-Chieh Lin, Chang-Wei Wu, Chia-Jung Liu, Lih-Yu Chang, Meng-Rui Lee, Jung-Yueh Chen, Jann-Yuan Wang

Aspergillus fumigatus-specific IgG is often used as a diagnostic test for chronic pulmonary aspergillosis (CPA), but few studies have evaluated the performance and serology of IgGs from species other than A. fumigatus. In this study, we evaluated the serology and performance of different Aspergillus species-specific IgG antibodies in patients with CPA and at-risk populations and whether different Aspergillus species-specific IgGs could be of clinical utility and aid in the diagnosis of CPA caused by all Aspergillus species. A total of 187 participants were included between 2020 and 2022 (12 with CPA, 75 with old tuberculosis [TB], 45 with active TB and 55 with bronchiectasis). We measured the serum Aspergillus fumigatus, flavus, terreus, niger-specific, and mixed Aspergillus IgG levels (Phadia ImmunoCap). The correlation was the strongest between A. fumigatus and A. niger (Spearman's rank: 0.940), followed by A. niger and A. flavus (Spearman's rank: 0.915). A. terreus-specific IgG was less strongly correlated with the other three Aspergillus species-specific IgG (Spearman's rank: 0.828-0.849). A. flavus (4 of 6, 67%) was the dominant species. Using the at-least-one-positive approach, the highest performance was obtained when A. fumigatus and A. flavus IgGs were used (sensitivity, 0.75; specificity, 0.84). Significant cross-reactivity exists among different Aspergillus-species IgGs although the correlation may be less significant for A. terreus. In addition to the commonly used A. fumigatus IgG test, IgGs specific to local prevalent Aspergillus species may provide additional clinical utility.

烟曲霉菌特异性 IgG 常被用作慢性肺曲霉菌病(CPA)的诊断检测,但很少有研究对烟曲霉菌以外的其他菌种的 IgG 的性能和血清学进行评估。在这项研究中,我们评估了不同曲霉菌种特异性 IgG 抗体在 CPA 患者和高危人群中的血清学表现,以及不同曲霉菌种特异性 IgG 是否具有临床实用性并有助于诊断由所有曲霉菌种引起的 CPA。我们在 2020 年至 2022 年间共纳入了 187 名参与者(其中 12 人患有 CPA,75 人患有陈旧性肺结核 [TB],45 人患有活动性肺结核,55 人患有支气管扩张症)。我们测量了血清曲霉菌、黄曲霉菌、赤曲霉菌、黑曲霉菌特异性和混合曲霉菌 IgG 水平(Phadia ImmunoCap)。烟曲霉和黑曲霉之间的相关性最强(Spearman's rank:0.940),其次是黑曲霉和黄曲霉(Spearman's rank:0.915)。赤霉菌特异性 IgG 与其他三种曲霉菌特异性 IgG 的相关性较弱(Spearman's rank:0.828-0.849)。黄曲霉(6 种中的 4 种,占 67%)是主要菌种。采用至少一阳性的方法,使用烟曲霉和黄曲霉的 IgG 性能最高(灵敏度为 0.75;特异性为 0.84)。不同曲霉菌种的 IgG 之间存在显著的交叉反应性,但对于赤曲霉来说,相关性可能不那么明显。除了常用的烟曲霉 IgG 检测外,当地流行曲霉菌种的特异性 IgG 可能会提供更多的临床用途。
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引用次数: 0
Hepatic schistosomiasis as a determining factor in the development of hepatic granulomas and liver fibrosis: a review of the current literature. 肝血吸虫病是导致肝肉芽肿和肝纤维化的决定性因素:现有文献综述。
IF 4.9 4区 医学 Q1 PARASITOLOGY Pub Date : 2024-09-13 DOI: 10.1080/20477724.2024.2400033
Lara-Cano R, Castañeda-Méndez P F, Uribe-Esquivel M, Barbero-Becerra V J

Hepatic schistosomiasis is a neglected parasitosis that affects millions of people each year worldwide and leads to high healthcare costs and increased morbidity and mortality in infected humans. It is a disease that has been widely studied in terms of its pathophysiology; therefore, the signaling pathways that lead to liver damage, with the consequent development of liver fibrosis, are now better understood. Research has elucidated the role of soluble egg antigen in the development of hepatic granulomas and liver fibrosis, the signal transducer and activator of transcription 3 and its participation in liver damage, the role of heat shock protein 47 and its involvement in liver fibrosis, the anti-inflammatory effects caused by interleukin-37, and the role of natural killer and natural killer T cells in the development of the disease. Hepatic schistosomiasis can range from simple hepatomegaly to the development of portal hypertension combined with hepatic fibrosis. For diagnostic purposes, a microscopic examination of excreta remains the gold standard; however, abdominal ultrasound has recently taken on an important role in the assessment of liver lesions produced by the parasite. Praziquantel is considered the management drug of choice, and has been associated with a potential preventive antifibrotic effect.

肝血吸虫病是一种被忽视的寄生虫病,每年影响全球数百万人,导致高昂的医疗费用以及受感染者发病率和死亡率的增加。人们已对这种疾病的病理生理学进行了广泛研究;因此,现在人们对导致肝损伤并进而发展为肝纤维化的信号通路有了更深入的了解。研究阐明了可溶性卵抗原在肝肉芽肿和肝纤维化发展中的作用、转录信号转导和激活因子 3 及其在肝损伤中的参与、热休克蛋白 47 的作用及其在肝纤维化中的参与、白细胞介素-37 的抗炎作用以及自然杀伤细胞和自然杀伤 T 细胞在疾病发展中的作用。肝血吸虫病可从单纯的肝肿大发展到门静脉高压合并肝纤维化。就诊断而言,对排泄物进行显微镜检查仍是金标准;但最近,腹部超声波在评估寄生虫引起的肝脏病变方面发挥了重要作用。吡喹酮被认为是首选的治疗药物,具有潜在的预防性抗纤维化作用。
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引用次数: 0
Genetic diversity, variation and recombination among the human papillomaviruses (HPVs) genomes isolated in China: a comparative genomic and phylogenetic analysis 中国分离的人乳头瘤病毒(HPV)基因组的遗传多样性、变异和重组:基因组和系统发育比较分析
IF 3.4 4区 医学 Q1 PARASITOLOGY Pub Date : 2024-09-12 DOI: 10.1080/20477724.2024.2401273
Pir Tariq Shah, Zhenyong Wu, Ruilan Ma, Chengjun Wu
Human papillomaviruses (HPVs) are widespread, sexually transmitted group of viruses that infect most individuals at some stage, causing genital warts and cancers. They are members of the Papillomav...
人类乳头瘤病毒(HPV)是一种广泛传播的性传播病毒,大多数人都会在某个阶段感染这种病毒,导致生殖器疣和癌症。它们是乳头状瘤病毒(Papillomavir...
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引用次数: 0
The first molecular record of Borrelia afzelii, B. garinii, B. valaisiana, B. burgdorferi s.s. and B. bavariensis in Bosnia and Herzegovina 在波斯尼亚和黑塞哥维那首次发现阿夫泽尔氏包柔氏菌、加里宁氏包柔氏菌、瓦莱西亚氏包柔氏菌、勃氏包柔氏杆菌和巴伐利亚氏包柔氏菌的分子记录
IF 3.4 4区 医学 Q1 PARASITOLOGY Pub Date : 2024-09-10 DOI: 10.1080/20477724.2024.2399380
Lejla Ušanović, Lejla Lasić, Naris Pojskić, Dalila Destanović, Jasna Hanjalić Kurtović, Belma Kalamujić Stroil
Borrelia burgdorferi sensu lato complex comprises 20 species, from which B. afzelii, B. garinii, B. burgdorferi sensu stricto, B. bavariensis, and B. spielmanii are directly associated with Lyme bo...
严格意义上的勃氏包柔氏菌、巴伐利亚包柔氏菌和斯皮尔曼包柔氏菌与莱姆病直接相关。
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引用次数: 0
Prevalence of Bordetella pertussis among children aged 4 years and above presenting with acute respiratory tract infection: a cross-sectional study. 一项横断面研究:4 岁及以上急性呼吸道感染儿童的百日咳博德特氏菌感染率。
IF 4.9 4区 医学 Q1 PARASITOLOGY Pub Date : 2024-09-08 DOI: 10.1080/20477724.2024.2400412
Ainun Nadzurah Binti Md Bahar, Anis Najwa Muhamad, Cindy Shuan Ju Teh, Mohamad Shafiq Adnan, Shah Adam, Shih Ying Hng, Kah Peng Eg, Anna Marie Nathan

Introduction and aim: In Malaysia, pertussis in children beyond infancy is underreported. This study aimed to determine the prevalence of Bordetella pertussis and the prevalence of pertussis-susceptible children aged ≥4 years who presented with acute respiratory infections.

Methods: This single-center, cross-sectional study conducted at the Paediatric Emergency Department from 1 October 2022, to 31 January 2023, included children aged 4 years and older with ARTIs symptoms and excluded those who were COVID-19 positive. B. pertussis was detected via quantitative Polymerase Chain Reaction on nasopharyngeal swabs and pertussis toxin (PT) IgG enzyme-linked immunosorbent assay.

Results: Children (n = 298) with a median (Interquartile range, [IQR]) age of 6.0 (5.0, 8.0) years old were recruited, and 98% were vaccinated adequately. Two cases of B. pertussis (n = 2/298, 0.67%) were detected. Both children were also co-infected with Bordetella spp. The majority of the patients (n = 246/296, 83.1%) had low protective antibodies against pertussis (anti-PT IgG <5 IU/ml), and children 5 years and older were more likely to have lower anti-PT Ig G levels of <5 IU/ml (odds ratio 2.02 [95% CI 1.04,3.90]) compared to children 4 years old.

Conclusion: The prevalence of pertussis was low. However, there is significant waning immunity. Booster doses of pertussis vaccine should be given to all school-aged children.

导言和目的:在马来西亚,婴儿期以后儿童的百日咳发病率较低。本研究旨在确定百日咳博德特氏菌的流行率以及急性呼吸道感染的≥4岁百日咳易感儿童的流行率:这项单中心横断面研究于 2022 年 10 月 1 日至 2023 年 1 月 31 日在儿科急诊室进行,研究对象包括有急性呼吸道感染症状的 4 岁及以上儿童,不包括 COVID-19 阳性的儿童。通过鼻咽拭子上的定量聚合酶链反应和百日咳毒素(PT)IgG酶联免疫吸附试验检测百日咳杆菌:招募的儿童(n = 298)的中位数(四分位数间距,[IQR])年龄为 6.0(5.0,8.0)岁,98%的儿童接种了适当的疫苗。发现两例百日咳杆菌病例(n = 2/298,0.67%)。大多数患者(n = 246/296,83.1%)的百日咳保护性抗体(抗 PT IgG)较低:百日咳发病率较低。然而,免疫力正在显著下降。所有学龄儿童都应接种加强剂量的百日咳疫苗。
{"title":"Prevalence of <i>Bordetella pertussis</i> among children aged 4 years and above presenting with acute respiratory tract infection: a cross-sectional study.","authors":"Ainun Nadzurah Binti Md Bahar, Anis Najwa Muhamad, Cindy Shuan Ju Teh, Mohamad Shafiq Adnan, Shah Adam, Shih Ying Hng, Kah Peng Eg, Anna Marie Nathan","doi":"10.1080/20477724.2024.2400412","DOIUrl":"https://doi.org/10.1080/20477724.2024.2400412","url":null,"abstract":"<p><strong>Introduction and aim: </strong>In Malaysia, pertussis in children beyond infancy is underreported. This study aimed to determine the prevalence of <i>Bordetella pertussis</i> and the prevalence of pertussis-susceptible children aged ≥4 years who presented with acute respiratory infections.</p><p><strong>Methods: </strong>This single-center, cross-sectional study conducted at the Paediatric Emergency Department from 1 October 2022, to 31 January 2023, included children aged 4 years and older with ARTIs symptoms and excluded those who were COVID-19 positive. <i>B. pertussis</i> was detected via quantitative Polymerase Chain Reaction on nasopharyngeal swabs and pertussis toxin (PT) IgG enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Children (<i>n</i> = 298) with a median (Interquartile range, [IQR]) age of 6.0 (5.0, 8.0) years old were recruited, and 98% were vaccinated adequately. Two cases of <i>B. pertussis</i> (<i>n</i> = 2/298, 0.67%) were detected. Both children were also co-infected with <i>Bordetella spp</i>. The majority of the patients (<i>n</i> = 246/296, 83.1%) had low protective antibodies against pertussis (anti-PT IgG <5 IU/ml), and children 5 years and older were more likely to have lower anti-PT Ig G levels of <5 IU/ml (odds ratio 2.02 [95% CI 1.04,3.90]) compared to children 4 years old.</p><p><strong>Conclusion: </strong>The prevalence of pertussis was low. However, there is significant waning immunity. Booster doses of pertussis vaccine should be given to all school-aged children.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review of enterovirus-associated hand-foot and mouth disease: preventive strategies and the need for a global enterovirus surveillance network. 回顾与肠道病毒相关的手足口病:预防策略和建立全球肠道病毒监测网络的必要性。
IF 4.9 4区 医学 Q1 PARASITOLOGY Pub Date : 2024-09-04 DOI: 10.1080/20477724.2024.2400424
Chien-Yuan Huang, Shih-Bin Su, Kow-Tong Chen

Enterovirus (EV)-associated hand, foot, and mouth disease (HFMD) is a significant public health issue worldwide, commonly occurring in children five years of age or younger. The leading causes of most HFMD cases are EVs, which are members of the Picornaviridae family. The typical clinical manifestations of EV-associated HFMD are febrile presentations with mucosal herpangina, oral ulcerations, and skin rashes on the hands and feet. The majority of HFMD cases resolve without consequence; however, a subset progresses to severe neurological and cardiopulmonary complications, which can be fatal. In the past two decades, EV-associated HFMD has received significant attention. In this review, we organize published papers and provide updates on epidemiology, pathogenesis, surveillance, and vaccine developments for EV-associated HFMD. The impact of EV-associated HFMD is increasing globally. Developing efficacious vaccines has become a priority for preventing EV infections without adequate treatment. Simultaneously, emerging EV infections (including EV-D68, EV-A71, Coxsackieviruses, and echoviruses) are increasing, highlighting the need to create a vigilant surveillance system for EV infections worldwide.

与肠道病毒(EV)相关的手足口病(HFMD)是全球范围内一个重要的公共卫生问题,通常发生在五岁或五岁以下的儿童身上。大多数手足口病病例的主要病原体是肠道病毒,它们属于皮科病毒科。EV 相关手足口病的典型临床表现是发热,伴有粘膜疱疹、口腔溃疡和手足皮疹。大多数手足口病病例可自行缓解,但也有一部分病例会发展为严重的神经系统和心肺并发症,甚至致命。在过去二十年中,与 EV 相关的手足口病受到了广泛关注。在这篇综述中,我们整理了已发表的论文,并提供了有关 EV 相关手足口病的流行病学、发病机制、监测和疫苗开发的最新信息。在全球范围内,EV 相关性手足口病的影响与日俱增。开发有效的疫苗已成为在没有适当治疗的情况下预防 EV 感染的当务之急。与此同时,新出现的 EV 感染(包括 EV-D68、EV-A71、柯萨奇病毒和埃可病毒)也在增加,这凸显了在全球范围内建立 EV 感染警惕性监测系统的必要性。
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引用次数: 0
Evaluation of the relationship between YKL-40 level and clinical severity in patients with Crimean-Congo hemorrhagic fever. 评估克里米亚-刚果出血热患者的 YKL-40 水平与临床严重程度之间的关系。
IF 4.9 4区 医学 Q1 PARASITOLOGY Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI: 10.1080/20477724.2024.2392225
Murat Aydin, Nurten Nur Aydin, Esra Laloğlu

Crimean-Congo hemorrhagic fever (CCHF) is a widespread tick-borne viral disease. YKL-40 (also known as chitinase-3-like-1 protein) is an acute phase protein released by various immune cells. The purpose of this study was to investigate the relationship between YKL-40 level and the clinical course and prognosis of CCHF. The study included 78 patients who were admitted to our hospital between April 15 and 30 August 2022 and had a positive polymerase chain reaction test result for CCHF. The patients were divided into two groups, severe and non-severe. In addition, a control group consisting of 22 healthy people was established. Mean serum YKL-40 levels were significantly higher in patients than controls (106.8 ng/mL ± 91.2 and 47.1 ng/mL ± 35.3, respectively; p < 0.001). However, mean YKL-40 levels were also significantly higher in patients with severe CCHF compared to non-severe cases (173.3 ± 112.3 and 67.5 ± 41.7, respectively; p < 0.001). A comparison of the 10 exitus patients and the 68 survivors revealed significantly higher YKL-40 levels in the exitus group (mean: 214.0 ± 139.0 and 92.8 ± 73.6, respectively; p = 0.001). A receiver operating characteristic analysis for YKL-40 levels to distinguish between severe and non-severe patients found an area under the curve of 0.925. YKL-40 levels were measured with a sensitivity of 97% and a specificity of 84% with a cutoff value of 90.7 ng/mL. YKL-40 levels measured at the time of hospital presentation in patients with CCHF can be used as a biomarker for clinical course and prognosis.

克里米亚-刚果出血热(CCHF)是一种广泛传播的蜱媒病毒性疾病。YKL-40(又称几丁质酶-3-样-1蛋白)是由各种免疫细胞释放的一种急性期蛋白。本研究旨在探讨YKL-40水平与CCHF临床病程和预后之间的关系。研究纳入了我院 2022 年 4 月 15 日至 8 月 30 日期间收治的 78 名聚合酶链反应检测结果呈阳性的慢性阻塞性肺疾病患者。患者被分为严重和非严重两组。此外,还设立了由 22 名健康人组成的对照组。患者血清中 YKL-40 的平均水平明显高于对照组(分别为 106.8 ng/mL ± 91.2 和 47.1 ng/mL ± 35.3;p p = 0.001)。对 YKL-40 水平进行接收器操作特征分析后发现,区分重度和非重度患者的曲线下面积为 0.925。以 90.7 纳克/毫升为临界值,YKL-40 水平的灵敏度为 97%,特异度为 84%。在CCHF患者入院时测量的YKL-40水平可作为临床病程和预后的生物标志物。
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引用次数: 0
Global and regional mortality statistics of nipah virus from 1994 to 2023: a comprehensive systematic review and meta-analysis. 1994 年至 2023 年全球和地区尼帕病毒死亡率统计:全面系统回顾和荟萃分析。
IF 4.9 4区 医学 Q1 PARASITOLOGY Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI: 10.1080/20477724.2024.2380131
Srivatsa Surya Vasudevan, Arun Subash, Fena Mehta, Tiba Yamin Kandrikar, Rupak Desai, Kaif Khan, Sneha Khanduja, Aakanksha Pitliya, Lekhya Raavi, Sai Gautham Kanagala, Piyush Gondaliya

The mortality rate of Nipah virus (NiV) can vary in different regions, and its pattern across timelines has yet to be assessed. The primary objective is to perform a comparative analysis of mortality rates across different timelines and countries. Articles reporting NiV mortality from inception to November 2023 were analyzed in PubMed, Ovid Embase, Scopus, and Web of Science databases. A meta-analysis utilizing random-effects models determined the mortality rate secondary to NiV complications. The initial search strategy yielded 1213 records, of which 36 articles met the inclusion criteria, comprising 2736 NiV patients. The Global mortality rate of the Nipah virus in the 2014-2023 decade was 80.1% (CI: 68.7-88.1%), indicating a significant 24% increase compared to the preceding decade (2004-2013) with a mortality rate of 54.1% (CI: 35.5-71.6%). Among the countries analyzed for overall mortality from 1994-2023, India experienced the highest mortality rate at 82.7% (CI: 74.6-88.6%), followed by Bangladesh at 62.1% (CI: 45.6-76.2%), Philippines at 52.9% (CI: 30-74.5%), Malaysia at 28.9% (CI: 21.4-37.9%), and Singapore at 21% (CI: 8-45%). Subgroup analysis revealed that India consistently had the highest mortality rate for the past two decades (91.7% and 89.3%). The primary complication leading to mortality was encephalitis, accounting for 95% of cases. This systematic review and meta-analysis revealed a noteworthy surge in NiV mortality rates, particularly in the current decade (2014-2023). The escalation, with India reporting a concerning level of mortality of 89.3-91.7% in the past decades, signifies a pressing public health challenge.

尼帕病毒(NiV)的死亡率在不同地区会有所不同,其在不同时间段的模式也有待评估。本研究的主要目的是对不同时间段和不同国家的死亡率进行比较分析。我们在 PubMed、Ovid Embase、Scopus 和 Web of Science 数据库中分析了从开始到 2023 年 11 月期间报告 NiV 死亡率的文章。利用随机效应模型进行的荟萃分析确定了继发于NiV并发症的死亡率。最初的搜索策略产生了 1213 条记录,其中 36 篇文章符合纳入标准,包括 2736 名 NiV 患者。2014-2023年十年间,尼帕病毒的全球死亡率为80.1%(CI:68.7-88.1%),与前十年(2004-2013年)54.1%(CI:35.5-71.6%)的死亡率相比,显著增加了24%。在 1994-2023 年总体死亡率分析国家中,印度的死亡率最高,为 82.7%(CI:74.6-88.6%),其次是孟加拉国的 62.1%(CI:45.6-76.2%)、菲律宾的 52.9%(CI:30-74.5%)、马来西亚的 28.9%(CI:21.4-37.9%)和新加坡的 21%(CI:8-45%)。分组分析显示,在过去二十年中,印度的死亡率一直最高(91.7% 和 89.3%)。导致死亡的主要并发症是脑炎,占 95% 的病例。这项系统回顾和荟萃分析显示,尼罗河病毒死亡率显著上升,尤其是在当前十年(2014-2023 年)。在过去几十年中,印度报告的死亡率为 89.3%-91.7%,令人担忧。
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引用次数: 0
JN.1 and the ongoing battle: unpacking the characteristics of a new dominant COVID-19 variant. JN.1 和正在进行的战斗:解读 COVID-19 新变种的特征。
IF 4.9 4区 医学 Q1 PARASITOLOGY Pub Date : 2024-09-01 Epub Date: 2024-06-17 DOI: 10.1080/20477724.2024.2369378
Reza Eshraghi, Ashkan Bahrami, Motahare Karimi Houyeh, Maryam Nasr Azadani

In the fourth year of the COVID-19 occurrence, a new COVID-19 variant, JN.1, has emerged and spread globally and become the dominant strain in several regions. It has some specific mutations in its spike proteins, empowering it with higher transmissibility. Regarding the significance of the issue, understanding the clinical and immunological traits of JN.1 is critical for enhancing health strategies and vaccination efforts globally, with the ultimate goal of bolstering our collective response to the pandemic. In this study, we take a look at the latest findings of JN.1 characteristics and mutations as well as its consequences on bypassing immune system. We demonstrate the importance of continual surveillance and strategic adaptation within healthcare frameworks along with the significance of wastewater sampling for the rapid identification of emerging SARS-CoV-2 variants.

在 COVID-19 出现的第四年,一种新的 COVID-19 变异株 JN.1 出现并在全球范围内传播,并成为多个地区的优势菌株。它的尖峰蛋白有一些特殊的突变,使其具有更高的传播性。就这一问题的意义而言,了解 JN.1 的临床和免疫学特征对于在全球范围内加强卫生策略和疫苗接种工作至关重要,其最终目标是加强我们对这一流行病的集体应对。在本研究中,我们探讨了有关 JN.1 特征和突变的最新发现,以及它对绕过免疫系统的影响。我们证明了在医疗保健框架内进行持续监控和战略调整的重要性,以及废水采样对快速识别新出现的 SARS-CoV-2 变异体的重要意义。
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引用次数: 0
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Pathogens and Global Health
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