Decoding the Auxin Matrix: Auxin Biology Through the Eye of the Computer.

IF 21.3 1区 生物学 Q1 PLANT SCIENCES Annual review of plant biology Pub Date : 2023-05-22 DOI:10.1146/annurev-arplant-102720-033523
Raquel Martin-Arevalillo, Teva Vernoux
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引用次数: 2

Abstract

The plant hormone auxin is certainly the most studied developmental regulator in plants. The many functions of auxin during development, from the embryo to the root and shoot construction, are mediated by an ever-growing collection of molecular regulators, with an overwhelming degree of both ubiquity and complexity that we are still far from fully understanding and that biological experiments alone cannot grasp. In this review, we discuss how bioinformatics and computational modeling approaches have helped in recent years to explore this complexity and to push the frontiers of our understanding of auxin biology. We focus on how analysis of massive amounts of genomic data and construction of computational models to simulate auxin-regulated processes at different scales have complemented wet experiments to increase the understanding of how auxin acts in the nucleus to regulate transcription and how auxin movement between cells regulates development at the tissular scale.

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解码生长素矩阵:通过计算机之眼的生长素生物学。
植物激素生长素无疑是研究最多的植物发育调节剂。生长素在发育过程中的许多功能,从胚胎到根和芽的构建,都是由不断增长的分子调节因子调节的,其普遍性和复杂性是我们远远不能完全理解的,单靠生物学实验也无法掌握。在这篇综述中,我们讨论了近年来生物信息学和计算建模方法如何帮助探索这种复杂性,并推动我们对生长素生物学理解的前沿。我们专注于如何分析大量的基因组数据和构建计算模型来模拟生长素在不同尺度上的调节过程,以补充湿实验,以增加对生长素如何在细胞核中调节转录以及细胞间生长素如何在组织尺度上调节发育的理解。
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来源期刊
Annual review of plant biology
Annual review of plant biology 生物-植物科学
CiteScore
40.40
自引率
0.40%
发文量
29
期刊介绍: The Annual Review of Plant Biology is a peer-reviewed scientific journal published by Annual Reviews. It has been in publication since 1950 and covers significant developments in the field of plant biology, including biochemistry and biosynthesis, genetics, genomics and molecular biology, cell differentiation, tissue, organ and whole plant events, acclimation and adaptation, and methods and model organisms. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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