THE1B may have no role in human pregnancy due to ZNF430-mediated silencing.

IF 4.7 2区 生物学 Q1 GENETICS & HEREDITY Mobile DNA Pub Date : 2023-05-22 DOI:10.1186/s13100-023-00294-6
Zheng Zuo
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引用次数: 1

Abstract

THE1-family retrovirus invaded the primate genome more than 40 million years ago. Dunn-Fletcher et al. reported one THE1B element upstream of CRH gene alters gestation length by upregulating corticotropin-releasing hormone expression in transgenic mice and concluded it has the same role in human as well. However, no promoter or enhancer mark has been detected around this CRH-proximal element in any human tissue or cell, so probably some anti-viral factor exists in primates to prevents it from wreaking havoc. Here I report two paralogous zinc finger genes, ZNF430 and ZNF100, that emerged during the simian lineage to specifically silence THE1B and THE1A, respectively. Contact residue changes in one finger confers each ZNF the unique ability to preferentially repress one THE1 sub-family over the other. The reported THE1B element contains an intact ZNF430 binding site, thus under the repression of ZNF430 in most tissues including placenta, it is questionable whether or not this retrovirus has any role in human pregnancy. Overall, this analysis highlights the need to study human retroviruses' functions in suitable model system.

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由于znf430介导的沉默,THE1B可能在人类妊娠中没有作用。
1家族逆转录病毒在4000多万年前侵入灵长类基因组。Dunn-Fletcher等报道了CRH基因上游的一个THE1B元件在转基因小鼠中通过上调促肾上腺皮质激素释放激素的表达来改变妊娠期长度,并得出其在人类中也具有相同作用的结论。然而,在任何人类组织或细胞中,没有在crh -近端元件周围检测到启动子或增强子标记,因此可能在灵长类动物中存在一些抗病毒因子来阻止它造成破坏。在这里,我报道了两个相似的锌指基因,ZNF430和ZNF100,它们分别出现在类人猿谱系中,特异性地沉默了THE1B和THE1A。一个手指的接触残留变化赋予每个ZNF优先抑制一个THE1亚家族的独特能力。报道的THE1B元件含有一个完整的ZNF430结合位点,因此在包括胎盘在内的大多数组织中,在ZNF430的抑制下,这种逆转录病毒是否在人类妊娠中有任何作用是值得怀疑的。总之,这一分析强调了在合适的模型系统中研究人类逆转录病毒功能的必要性。
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来源期刊
Mobile DNA
Mobile DNA GENETICS & HEREDITY-
CiteScore
8.20
自引率
6.10%
发文量
26
审稿时长
11 weeks
期刊介绍: Mobile DNA is an online, peer-reviewed, open access journal that publishes articles providing novel insights into DNA rearrangements in all organisms, ranging from transposition and other types of recombination mechanisms to patterns and processes of mobile element and host genome evolution. In addition, the journal will consider articles on the utility of mobile genetic elements in biotechnological methods and protocols.
期刊最新文献
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