María Teresa Miras Portugal: a pioneer in the study of purinoceptors in chromaffin cells.

IF 3 4区 医学 Q2 NEUROSCIENCES Purinergic Signalling Pub Date : 2024-04-01 Epub Date: 2023-03-21 DOI:10.1007/s11302-023-09934-1
Antonio R Artalejo, Marina Arribas-Blázquez, María Victoria Barahona, Celia Llorente-Sáez, Luis Alcides Olivos-Oré
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Abstract

María Teresa Miras Portugal devoted most of her scientific life to the study of purinergic signalling. In an important part of her work, she used a model system: the chromaffin cells of the adrenal medulla. It was in these cells that she identified diadenosine polyphosphates, from which she proceeded to the study of adrenomedullary purinome: nucleotide synthesis and degradation, adenosine transport, nucleotide uptake into chromaffin granules, exocytotic release of nucleotides and autocrine regulation of chromaffin cell function via purinoceptors. This short review will focus on the current state of knowledge of the purinoceptors of adrenal chromaffin cells, a subject to which María Teresa made seminal contributions and which she continued to study until the end of her scientific life.

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玛丽亚-特雷莎-米拉斯-葡萄牙:研究嗜铬细胞嘌呤受体的先驱。
玛丽亚-特雷莎-米拉斯-葡萄牙毕生致力于嘌呤能信号的研究。在她工作的重要部分,她使用了一个模型系统:肾上腺髓质的绒毛膜细胞。正是在这些细胞中,她发现了二腺苷多磷酸盐,并由此开始了对肾上腺髓质嘌呤基因组的研究:核苷酸的合成和降解、腺苷转运、核苷酸摄入嗜铬细胞颗粒、核苷酸的外排释放以及通过嘌呤受体对嗜铬细胞功能的自分泌调节。玛丽亚-特雷莎对这一课题做出了开创性的贡献,并一直研究到其科学生涯的最后一刻。
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来源期刊
Purinergic Signalling
Purinergic Signalling 医学-神经科学
CiteScore
6.60
自引率
17.10%
发文量
75
审稿时长
6-12 weeks
期刊介绍: Nucleotides and nucleosides are primitive biological molecules that were utilized early in evolution both as intracellular energy sources and as extracellular signalling molecules. ATP was first identified as a neurotransmitter and later as a co-transmitter with all the established neurotransmitters in both peripheral and central nervous systems. Four subtypes of P1 (adenosine) receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of P2Y G protein-coupled receptors have currently been identified. Since P2 receptors were first cloned in the early 1990’s, there is clear evidence for the widespread distribution of both P1 and P2 receptor subtypes in neuronal and non-neuronal cells, including glial, immune, bone, muscle, endothelial, epithelial and endocrine cells.
期刊最新文献
Correction to: Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist. Machine learning-aided search for ligands of P2Y6 and other P2Y receptors. Purinergic regulation of pulmonary vascular tone. Role of ecto-5'-nucleotidase in bladder function activity and smooth muscle contractility. Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia.
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