Diabetes in HIV: the Link to Weight Gain.

IF 3.7 2区 医学 Q2 INFECTIOUS DISEASES Current HIV/AIDS Reports Pub Date : 2023-02-01 Epub Date: 2022-11-23 DOI:10.1007/s11904-022-00642-w
Samuel S Bailin, John R Koethe
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Abstract

Purpose of review: The burden of metabolic diseases, including type 2 diabetes mellitus (T2DM), is rising among persons with HIV (PWH) on antiretroviral therapy (ART). This increase coincides with an aging population and a greater proportion who are overweight/obese. This review summarizes the changing epidemic of T2DM on contemporary ART, the role of weight gain, and therapeutic options.

Recent findings: Recent studies confirm that PWH face an epidemic of obesity and T2DM, similar to the general population. Contemporary ART is associated with greater weight gain and may contribute to the risk of T2DM. Recent advances in medical weight loss therapy offer a way forward in the prevention and treatment of weight-associated T2DM. Weight gain is one of the biggest contributors to T2DM in PWH. Future studies on the role of adipose tissue distribution, adipose tissue function and clinical use of effective weight loss medications may change the paradigm of care for PWH.

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艾滋病患者的糖尿病:与体重增加的关系。
综述目的:在接受抗逆转录病毒疗法(ART)的艾滋病病毒感染者(PWH)中,包括 2 型糖尿病(T2DM)在内的代谢性疾病的负担正在增加。这一增长与人口老龄化和超重/肥胖比例增加相吻合。本综述总结了 T2DM 在当代抗逆转录病毒疗法中的流行变化、体重增加的作用以及治疗方案:最近的研究证实,与普通人群相似,残疾人也面临着肥胖和 T2DM 的流行。当代抗逆转录病毒疗法与体重增加有关,可能会增加罹患 T2DM 的风险。医学减重疗法的最新进展为预防和治疗与体重相关的 T2DM 提供了一条出路。体重增加是导致肥胖者患 T2DM 的最大因素之一。未来对脂肪组织分布、脂肪组织功能以及有效减肥药物的临床应用的研究可能会改变 PWH 的治疗模式。
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来源期刊
Current HIV/AIDS Reports
Current HIV/AIDS Reports INFECTIOUS DISEASES-
CiteScore
8.10
自引率
2.20%
发文量
45
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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