Prognostic Nomograms for Patients with Primary Sarcomatoid Carcinoma of The Urinary Bladder: Based on The SEER Database.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY Urology Journal Pub Date : 2024-03-24 DOI:10.22037/uj.v20i.7595

Chengyun Xu, Bing Xiong

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引用次数: 0

Abstract

Purpose: The present study aimed to develop nomograms based on the SEER database to predict the prognosis for patients with primary sarcomatoid carcinoma of the urinary bladder (SCUB).

Materials and methods: Patients with primary SCUB were identified in the Surveillance, Epidemiology, and End Results (SEER) database, between 1975 and 2017. Univariate and multivariable Cox analysis were conducted to identify the independent prognostic factors for developing the overall survival (OS) and cancer-specific survival (CSS) nomograms. Then, concordance index (C-index), receiver operating characteristic (ROC) curve and calibration curve were used to evaluate the accuracy of the nomogram model. In addition, the model was further compared with TNM staging system.

Results: A total of 238 eligible patients with primary SCUB were selected from the SEER database. As suggested by Cox-analysis, age, sex, T stage, M stage, tumor size, and surgery type of primary site were identified as the independent factors for predicting both OS and CSS. We developed OS and CSS nomograms with a favorable C-index by using these prognostic factors. The C-indexes of the OS and CSS nomogram in the present study were 0.738 (0.701-0.775) and 0.763 (0.724-0.802), which were superior to those of the AJCC TNM staging with 0.621 (0.576-0.666) and 0.637 (0.588-0.686) respectively, showing better discriminatory ability. Subsequently, the ROC curves showed that the 1-, 3- and 5-year AUCs (area under the curve) of OS nomogram (i.e., 0.793, 0.807 and 0.793) were higher than those of the TNM stage((i.e., 0.659, 0.676, 0.659). Similarly, as for CSS model, them ((i.e., 0.823, 0.804 and 0.804) were aslo exceed those of TNM stage((i.e., 0.683, 0.682, 0.682). Furthermore, the calibration curves indicated a good consistency between the predictive survival and the actual survival. Finally, patients were stratified by risk, and Kaplan-Meier survival curve suggested that the prognosis of the low-risk group was significantly better than that of the high-risk group.

Conclusion: We developed nomograms with the SEER database, which could help predict the prognosis of SCUB individuals more accurately.

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膀胱原发性肉瘤样癌患者的预后提名图：基于 SEER 数据库。

目的：本研究旨在基于SEER数据库开发预测原发性膀胱肉瘤样癌（SCUB）患者预后的提名图：1975年至2017年间，原发性膀胱肉瘤样癌（SCUB）患者在监测、流行病学和最终结果（SEER）数据库中被识别。进行了单变量和多变量 Cox 分析，以确定制定总生存期（OS）和癌症特异性生存期（CSS）提名图的独立预后因素。然后，使用一致性指数（C-index）、接收者操作特征曲线（ROC）和校准曲线来评估提名图模型的准确性。此外，该模型还与 TNM 分期系统进行了进一步比较：结果：从 SEER 数据库中筛选出 238 名符合条件的原发性 SCUB 患者。Cox分析显示，年龄、性别、T分期、M分期、肿瘤大小和原发部位的手术类型是预测OS和CSS的独立因素。我们利用这些预后因素绘制了具有良好 C 指数的 OS 和 CSS 直方图。本研究中，OS和CSS提名图的C指数分别为0.738（0.701-0.775）和0.763（0.724-0.802），优于AJCC TNM分期的0.621（0.576-0.666）和0.637（0.588-0.686），显示出更好的判别能力。随后的ROC曲线显示，OS提名图的1年、3年和5年AUC（曲线下面积）（即0.793、0.807和0.793）均高于TNM分期的AUC（即0.659、0.676和0.659）。同样，CSS 模型（即 0.823、0.804 和 0.804）也高于 TNM 分期模型（即 0.683、0.682 和 0.682）。此外，校准曲线显示预测生存率与实际生存率之间具有良好的一致性。最后，对患者进行了风险分层，Kaplan-Meier 生存曲线显示，低风险组的预后明显优于高风险组：结论：我们利用 SEER 数据库绘制的提名图有助于更准确地预测 SCUB 患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urology Journal UROLOGY & NEPHROLOGY-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist. Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.