Effectiveness of ketorolac-soaked bandage contact lens for pain management after photorefractive keratectomy.

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2023-06-01 DOI:10.1080/15569527.2023.2201832
Fikret Ucar, Ekrem Kadioglu
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Abstract

Objective: To evaluate the effect of ketorolac-soaked contact lenses (CLs) on postoperative pain after photorefractive keratectomy (PRK) and their potential side effects including conjunctival hyperaemia and delayed epithelial healing.

Methods: This is a prospective, randomised, double-blind, contralateral eye study. A total of 310 eyes of 155 patients who underwent PRK in both eyes were included in the study. After photoablation, a 0.4% ketorolac-soaked bandage CL was placed over the cornea in Group 1, while a drug-free soft bandage CL was placed over the cornea in Group 2. The postoperative pain was evaluated using a verbal numerical rating scale. The ocular redness was compared using the black pixels (veins, and areas of redness) and white pixels (remaining areas) of the images. The complications and time to corneal wound healing were also recorded.

Results: The mean pain score was significantly lower in Group 1 (2.7 ± 1.3) than in Group 2 (7.4 ± 1.4) on postoperative day 1 (p < 0.001). However, on the 3rd postoperative day, there was no significant difference between the groups in terms of pain scores (p = 0.42). Preoperative eye redness was 199.2 ± 16.0 pixels in Group 1 and 200.1 ± 17.6 pixels in Group 2 (p = 0.65). There was no statistically significant difference between the two groups in terms of eye redness at the postoperative 24th and 72nd hours (p = 0.43 and p = 0.39, respectively).

Conclusion: Soaking the bandage CL in a solution containing ketorolac 0.4% for 15 minutes could significantly lower pain scores on the first postoperative day after PRK, with no serious complications.

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酮酸浸渍绷带隐形眼镜在光屈光性角膜切除术后疼痛治疗中的效果。
目的:评价酮酸浸隐形眼镜(CLs)对光屈光性角膜切除术(PRK)术后疼痛的影响及其潜在的副作用,包括结膜充血和上皮细胞愈合延迟。方法:这是一项前瞻性、随机、双盲、对侧眼研究。155名双眼接受PRK的患者共310只眼睛被纳入研究。光消融后,第1组在角膜上放置0.4%酮咯酸浸泡的绷带CL,第2组在角膜上放置无药物软绷带CL。术后疼痛采用口头数字评定量表进行评估。使用图像的黑色像素(静脉和红色区域)和白色像素(剩余区域)比较眼红度。并记录并发症及角膜创面愈合时间。结果:术后第1天,组1患者的平均疼痛评分(2.7±1.3)分明显低于组2患者(7.4±1.4)分(p p = 0.42)。术前1组眼红肿为199.2±16.0象素,2组为200.1±17.6象素(p = 0.65)。两组患者术后24、72小时眼红肿程度比较,差异均无统计学意义(p = 0.43、p = 0.39)。结论:在含0.4%酮罗拉酸溶液中浸泡绷带CL 15分钟可显著降低PRK术后第1天疼痛评分,无严重并发症。
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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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