Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Current Osteoporosis Reports Pub Date : 2023-02-01 Epub Date: 2022-12-24 DOI:10.1007/s11914-022-00772-5

Husam Bensreti, Dima W Alhamad, Alejandro Marrero Gonzalez, Manuel Pizarro-Mondesir, Wendy B Bollag, Carlos M Isales, Meghan E McGee-Lawrence

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Abstract

Purpose of review: Bone marrow adipose tissue (BMAT) in the skeleton likely plays a variety of physiological and pathophysiological roles that are not yet fully understood. In elucidating the complex relationship between bone and BMAT, glucocorticoids (GCs) are positioned to play a key role, as they have been implicated in the differentiation of bone marrow mesenchymal stem cells (BMSCs) between osteogenic and adipogenic lineages. The purpose of this review is to illuminate aspects of both endogenous and exogenous GC signaling, including the influence of GC receptors, in mechanisms of bone aging including relationships to BMAT.

Recent findings: Harmful effects of GCs on bone mass involve several cellular pathways and events that can include BMSC differentiation bias toward adipogenesis and the influence of mature BMAT on bone remodeling through crosstalk. Interestingly, BMAT involvement remains poorly explored in GC-induced osteoporosis and warrants further investigation. This review provides an update on the current understanding of the role of glucocorticoids in the biology of osteoblasts and bone marrow adipocytes (BMAds).

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糖皮质激素信号在骨母细胞和骨髓脂肪细胞衰老过程中的作用的最新进展。

综述的目的：骨骼中的骨髓脂肪组织（BMAT）可能发挥着各种生理和病理生理学作用，但人们对这些作用尚未完全了解。在阐明骨与骨髓脂肪组织之间的复杂关系时，糖皮质激素（GCs）将发挥关键作用，因为它们与骨髓间充质干细胞（BMSCs）在成骨和成脂系之间的分化有关。本综述旨在阐明内源性和外源性 GC 信号转导的各个方面，包括 GC 受体对骨老化机制的影响，包括与 BMAT 的关系：最近的研究结果：GCs 对骨质的有害影响涉及多种细胞途径和事件，其中可能包括 BMSC 向脂肪生成的分化偏向以及成熟 BMAT 通过串扰对骨重塑的影响。有趣的是，在 GC 诱导的骨质疏松症中，BMAT 的参与仍未得到充分探讨，值得进一步研究。本综述介绍了目前对糖皮质激素在成骨细胞和骨髓脂肪细胞（BMAds）生物学中作用的最新认识。

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.