Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama Study

IF 6.2 2区 医学 Q1 ALLERGY Allergology International Pub Date : 2024-01-01 DOI:10.1016/j.alit.2023.04.005
Noriyuki Tashima , Hisako Matsumoto , Kenta Nishi , Satoru Terada , Mariko Kogo , Natsuko Nomura , Chie Morimoto , Hironobu Sunadome , Tadao Nagasaki , Tsuyoshi Oguma , Yoshinari Nakatsuka , Kimihiko Murase , Takahisa Kawaguchi , Yasuharu Tabara , Kazuo Chin , Kazuhiro Sonomura , Fumihiko Matsuda , Toyohiro Hirai
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引用次数: 1

Abstract

Background

Obesity and increased body mass index (BMI) are the known risk factors for adult-onset asthma. Serum free fatty acid (FFA) and other blood lipid levels are generally elevated in patients with obesity and may be involved in the onset of asthma. However, it remains largely unknown. This study aimed to elucidate the relationship between plasma fatty acids and new-onset asthma.

Methods

This community-based Nagahama Study in Japan enrolled 9804 residents. We conducted self-reporting questionnaires, lung function tests, and blood tests at baseline and 5 years later as follow-up. At the follow-up, plasma fatty acids were measured using gas chromatography-mass spectrometry. Body composition analysis was also measured at the follow-up. The associations between fatty acids and new-onset asthma were evaluated using a multifaceted approach, including targeted partial least squares discriminant analysis (PLS-DA).

Results

In PLS-DA for new-onset asthma, palmitoleic acid was identified as the fatty acid most associated with asthma onset. In the multivariable analysis, higher levels of FFA, palmitoleic acid, or oleic acid were significantly associated with new-onset asthma, independent of other confounding factors. The high body fat percentage itself was not the relevant factor, but showed a positive interaction with plasma palmitoleic acid for new-onset asthma. When stratified by gender, the impacts of higher levels of FFA or palmitoleic acid on new-onset asthma remained significant in females, but not in males.

Conclusions

Elevated levels of plasma fatty acids, particularly palmitoleic acid, may be a relevant factor for new-onset asthma.

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评估血浆脂肪酸升高与成人哮喘的相关因素:长滨研究
背景肥胖和体重指数(BMI)升高是成人哮喘发病的已知风险因素。肥胖患者的血清游离脂肪酸(FFA)和其他血脂水平普遍升高,可能与哮喘的发病有关。然而,这在很大程度上仍是个未知数。本研究旨在阐明血浆脂肪酸与新发哮喘之间的关系。我们在基线和 5 年后的随访中进行了自我报告问卷调查、肺功能测试和血液测试。随访时,我们使用气相色谱-质谱法测量了血浆脂肪酸。随访时还进行了身体成分分析。采用目标偏最小二乘判别分析(PLS-DA)等多方面方法评估了脂肪酸与新发哮喘之间的关联。在多变量分析中,较高水平的脂肪酸、棕榈油酸或油酸与新发哮喘显著相关,与其他干扰因素无关。高体脂百分比本身并非相关因素,但与血浆棕榈油酸对新发哮喘的影响呈正交互作用。结论血浆脂肪酸(尤其是棕榈油酸)水平升高可能是导致新发哮喘的一个相关因素。
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来源期刊
Allergology International
Allergology International ALLERGY-IMMUNOLOGY
CiteScore
12.60
自引率
5.90%
发文量
96
审稿时长
29 weeks
期刊介绍: Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related diseases. Papers may include the study of methods of controlling allergic reactions, human and animal models of hypersensitivity and other aspects of basic and applied clinical allergy in its broadest sense. The Journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following three categories: Original Articles, Review Articles, and Letters to the Editor.
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