Physical biomarkers for human hematopoietic stem and progenitor cells

IF 3.9 4区生物学 Q4 Biochemistry, Genetics and Molecular Biology Cells and Development Pub Date : 2023-06-01 DOI:10.1016/j.cdev.2023.203845

Motomu Tanaka , Judith Thoma , Laura Poisa-Beiro , Patrick Wuchter , Volker Eckstein , Sascha Dietrich , Caroline Pabst , Carsten Müller-Tidow , Takao Ohta , Anthony D. Ho

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Abstract

Adhesion of hematopoietic stem and progenitor cells (HSPCs) to the bone marrow niche plays critical roles in the maintenance of the most primitive HSPCs. The interactions of HSPC−niche interactions are clinically relevant in acute myeloid leukemia (AML), because (i) leukemia-initiating cells adhered to the marrow niche are protected from the cytotoxic effect by chemotherapy and (ii) mobilization of HSPCs from healthy donors' bone marrow is crucial for the effective stem cell transplantation. However, although many clinical agents have been developed for the HSPC mobilization, the effects caused by the extrinsic molecular cues were traditionally evaluated based on phenomenological observations. This review highlights the recent interdisciplinary challenges of hematologists, biophysicists and cell biologists towards the design of defined in vitro niche models and the development of physical biomarkers for quantitative indexing of differential effects of clinical agents on human HSPCs.

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人造血干细胞和祖细胞的物理生物标志物

造血干细胞和祖细胞（HSPCs）与骨髓小生境的粘附在维持最原始的HSPCs中起着关键作用。HSPC-小生境相互作用的相互作用在急性髓性白血病（AML）中具有临床相关性，因为（i）粘附在骨髓小生境上的白血病起始细胞受到化疗的保护，免受细胞毒性作用；（ii）从健康供体骨髓动员HSPC对有效的干细胞移植至关重要。然而，尽管已经开发了许多用于HSPC动员的临床药物，但传统上基于现象学观察来评估外源性分子线索引起的影响。这篇综述强调了血液学家、生物物理学家和细胞生物学家最近在设计定义的体外小生境模型和开发物理生物标志物方面面临的跨学科挑战，用于定量索引临床药物对人类HSPCs的不同影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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