Extracellular vesicles as personalized medicine

IF 8.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Aspects of Medicine Pub Date : 2023-06-01 DOI:10.1016/j.mam.2022.101155

Danielle J. Beetler , Damian N. Di Florio , Katelyn A. Bruno , Tsuneya Ikezu , Keith L. March , Leslie T. Cooper Jr. , Joy Wolfram , DeLisa Fairweather

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引用次数: 14

Abstract

Extracellular vesicles (EVs) are released from all cells in the body, forming an important intercellular communication network that contributes to health and disease. The contents of EVs are cell source-specific, inducing distinct signaling responses in recipient cells. The specificity of EVs and their accumulation in fluid spaces that are accessible for liquid biopsies make them highly attractive as potential biomarkers and therapies for disease. The duality of EVs as favorable (therapeutic) or unfavorable (pathological) messengers is context dependent and remains to be fully determined in homeostasis and various disease states. This review describes the use of EVs as biomarkers, drug delivery vehicles, and regenerative therapeutics, highlighting examples involving viral infections, cancer, and neurological diseases. There is growing interest to provide personalized therapy based on individual patient and disease characteristics. Increasing evidence suggests that EV biomarkers and therapeutic approaches are ideal for personalized medicine due to the diversity and multifunctionality of EVs.

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细胞外囊泡作为个性化药物

细胞外小泡（EV）从体内所有细胞中释放出来，形成一个重要的细胞间通信网络，有助于健康和疾病。EVs的含量是细胞源特异性的，在受体细胞中诱导不同的信号反应。EVs的特异性及其在液体活检可进入的液体空间中的积累使其作为潜在的疾病生物标志物和疗法极具吸引力。EVs作为有利（治疗）或不利（病理）信使的双重性取决于环境，在稳态和各种疾病状态下仍有待完全确定。这篇综述描述了电动汽车作为生物标志物、药物输送载体和再生疗法的使用，重点介绍了涉及病毒感染、癌症和神经疾病的例子。人们对提供基于个体患者和疾病特征的个性化治疗越来越感兴趣。越来越多的证据表明，由于电动汽车的多样性和多功能性，电动汽车生物标志物和治疗方法是个性化医学的理想选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Aspects of Medicine 医学-生化与分子生物学

CiteScore

18.20

自引率

0.00%

发文量

审稿时长

55 days

期刊介绍： Molecular Aspects of Medicine is a review journal that serves as an official publication of the International Union of Biochemistry and Molecular Biology. It caters to physicians and biomedical scientists and aims to bridge the gap between these two fields. The journal encourages practicing clinical scientists to contribute by providing extended reviews on the molecular aspects of a specific medical field. These articles are written in a way that appeals to both doctors who may struggle with basic science and basic scientists who may have limited awareness of clinical practice issues. The journal covers a wide range of medical topics to showcase the molecular insights gained from basic science and highlight the challenging problems that medicine presents to the scientific community.

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