Modafinil-excipient compatibility study using differential scanning calorimetry.

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-04-01 Epub Date: 2023-04-13 DOI:10.4103/japtr.japtr_663_22
Derar Omari, Assayed Sallam, Hasan Al-Hmoud, Iyad Rashid
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引用次数: 1

Abstract

Drug excipient compatibility studies are considered important in successful formulation of drug products. Suggested methods for this purpose are thermal techniques under isothermal or nonisothermal conditions. In this study, modafinil, a wakefulness-promoting drug, was investigated under nonisothermal conditions using differential scanning calorimetry. Four different heating rates, 5, 10, 15, and 20°C/min, were performed for modafinil pure material and its physical mixtures with magnesium stearate (MgSt) or Gelucire 48/16. Activation energy (Ea) was calculated from the straight line of plotting a function of heating rate versus temperature and found that modafinil-Gelucire physical mixture increased Ea. This indicates drug-excipient interaction, supported by evidence from Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. No significant interaction was detected with MgSt.

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莫达非尼赋形剂相容性的差示扫描量热法研究。
药物赋形剂兼容性研究被认为是成功配制药物产品的重要因素。为此目的建议的方法是在等温或非等温条件下的热技术。在本研究中,使用差示扫描量热法在非等温条件下研究了促醒药物莫达非尼。对莫达非尼纯材料及其与硬脂酸镁(MgSt)或Gelucire 48/16的物理混合物进行了4种不同的加热速率,即5、10、15和20°C/min。从绘制加热速率与温度的函数的直线计算活化能(Ea),发现莫达非尼-凝胶物理混合物增加了Ea。这表明药物-赋形剂相互作用,傅立叶变换红外光谱和核磁共振光谱的证据支持这一点。未检测到与MgSt的显著相互作用。
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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
44
审稿时长
20 weeks
期刊介绍: Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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