A Nested Case-Control Study to Explore the Association between Immunoglobulin G N-glycans and Ischemic Stroke

IF 3 3区医学 Q2 ENVIRONMENTAL SCIENCES Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI:10.3967/bes2023.048

WANG Bi Yan , SONG Man Shu , ZHANG Jie , MENG Xiao Ni , XING Wei Jia , WANG You Xin

{"title":"A Nested Case-Control Study to Explore the Association between Immunoglobulin G N-glycans and Ischemic Stroke","authors":"WANG Bi Yan , SONG Man Shu , ZHANG Jie , MENG Xiao Ni , XING Wei Jia , WANG You Xin","doi":"10.3967/bes2023.048","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>This study prospectively investigates the association between immunoglobulin G (IgG) N-glycan traits and ischemic stroke (IS) risk.</p></div><div><h3>Methods</h3><p>A nested case-control study was conducted in the China suboptimal health cohort study, which recruited 4,313 individuals in 2013–2014. Cases were identified as patients diagnosed with IS, and controls were 1:1 matched by age and sex with cases. IgG N-glycans in baseline plasma samples were analyzed.</p></div><div><h3>Results</h3><p>A total of 99 IS cases and 99 controls were included, and 24 directly measured glycan peaks (GPs) were separated from IgG N-glycans. In directly measured GPs, GP4, GP9, GP21, GP22, GP23, and GP24 were associated with the risk of IS in men after adjusting for age, waist and hip circumference, obesity, diabetes, hypertension, and dyslipidemia. Derived glycan traits representing decreased galactosylation and sialylation were associated with IS in men (FBG2S2/(FBG2 + FBG2S1 + FBG2S2): odds ratio (<em>OR</em>) = 0.92, 95% confidence interval (<em>CI</em>): 0.87–0.97; G1<sup>n</sup>: <em>OR</em> = 0.74, 95% <em>CI</em>: 0.63–0.87; G0<sup>n</sup>: <em>OR</em> = 1.12, 95% <em>CI</em>: 1.03–1.22). However, these associations were not found among women.</p></div><div><h3>Conclusion</h3><p>This study validated that altered IgG N-glycan traits were associated with incident IS in men, suggesting that sex discrepancies might exist in these associations.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 389-396"},"PeriodicalIF":3.0000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical and Environmental Sciences","FirstCategoryId":"1089","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0895398823000673","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

This study prospectively investigates the association between immunoglobulin G (IgG) N-glycan traits and ischemic stroke (IS) risk.

Methods

A nested case-control study was conducted in the China suboptimal health cohort study, which recruited 4,313 individuals in 2013–2014. Cases were identified as patients diagnosed with IS, and controls were 1:1 matched by age and sex with cases. IgG N-glycans in baseline plasma samples were analyzed.

Results

A total of 99 IS cases and 99 controls were included, and 24 directly measured glycan peaks (GPs) were separated from IgG N-glycans. In directly measured GPs, GP4, GP9, GP21, GP22, GP23, and GP24 were associated with the risk of IS in men after adjusting for age, waist and hip circumference, obesity, diabetes, hypertension, and dyslipidemia. Derived glycan traits representing decreased galactosylation and sialylation were associated with IS in men (FBG2S2/(FBG2 + FBG2S1 + FBG2S2): odds ratio (OR) = 0.92, 95% confidence interval (CI): 0.87–0.97; G1ⁿ: OR = 0.74, 95% CI: 0.63–0.87; G0ⁿ: OR = 1.12, 95% CI: 1.03–1.22). However, these associations were not found among women.

Conclusion

This study validated that altered IgG N-glycan traits were associated with incident IS in men, suggesting that sex discrepancies might exist in these associations.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

一项探讨免疫球蛋白G - n -聚糖与缺血性脑卒中关系的巢式病例对照研究

目的本研究前瞻性地探讨免疫球蛋白G（IgG）N-聚糖特征与缺血性脑卒中（IS）风险之间的关系。方法在中国次优健康队列研究中进行嵌套病例对照研究，该研究在2013-2014年招募了4313名个体。病例被确定为诊断为IS的患者，对照组按年龄和性别与病例1:1匹配。分析基线血浆样品中的IgG N-聚糖。结果共纳入99例IS病例和99例对照组，从IgG N-聚糖中分离出24个直接测量的聚糖峰（GP）。在直接测量的全科医生中，在调整了年龄、腰围和臀围、肥胖、糖尿病、高血压和血脂异常后，GP4、GP9、GP21、GP22、GP23和GP24与男性IS风险相关。代表半乳糖基化和唾液酸化减少的衍生聚糖特征与男性IS相关（FBG2S2/（FBG2+FBG2S1+FBG2S2）：比值比（OR）=0.92，95%置信区间（CI）=0.87–0.97；G1n:OR=0.74，95%置信区间：0.63–0.87；G0n:OR=1.12，95%CI:1.03-1.22）。然而，在女性中没有发现这些关联。结论本研究证实了IgG N-聚糖特征的改变与男性发生IS有关，表明这些相关性中可能存在性别差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Biomedical and Environmental Sciences 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

2.60

自引率

8.60%

发文量

2170

审稿时长

1.0 months

期刊介绍： Biomedical and Environmental Sciences (BES) is a peer-reviewed journal jointly established by the Chinese Center for Disease Control and Prevention (China CDC) and the Coulston International Corporation (CIC), USA in 1988, and is published monthly by Elsevier. It is indexed by SCI, PubMed, and CA. Topics covered by BES include infectious disease prevention, chronic and non-communicable disease prevention, disease control based on preventive medicine, and public health theories. It also focuses on the health impacts of environmental factors in people''s daily lives and work, including air quality, occupational hazards, and radiation hazards. Article types considered for publication include original articles, letters to the editor, reviews, research highlights, and policy forum.