Key population perceptions and opinions about long-acting antiretrovirals for prevention and treatment: a scoping review.

IF 4.5 3区医学 Q2 IMMUNOLOGY Current Opinion in HIV and AIDS Pub Date : 2022-05-01 DOI:10.1097/COH.0000000000000734

Omar Sued, Norma Nardi, Luciana Spadaccini

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引用次数: 8

Abstract

Purpose of review: Key populations are disproportionately affected by human immunodeficiency virus (HIV). Access, retention, and adherence are important barriers for the efficacy of preexposure prophylaxis (PrEP) and HIV treatment among these populations. Long-acting (LA) antiretrovirals hold the promise to solve some of these backdrops. The objective of the current review is to update the perceptions of key populations and PLWH about LA, based on their opinion, acceptability, and willingness to use it.

Recent findings: According to the review preferences for LA vary with the population studied. Regarding people living with HIV (PLWH), male having sex with men are interested in having different options, adolescents are interested in LA (strong preference for implants), yet also perceive substantial obstacles to using biomedical prevention; transgender women aimed to nonvisible small implants, with long-lasting effects or LA injections that can be applied in other areas than buttocks, and women who experienced history of medical injections might increase preference for LA (except for history of people who inject drugs [IDU]). Female sex workers and IDU both showed interest in LA-PrEP. Regarding antiretroviral therapy, LA increased treatment satisfaction and acceptance, mainly among those receiving injections every 2 months. LA helped overcome pill fatigue, stigma, and adherence issues.

Summary: Knowing preferences for biomedical interventions will contribute to better understanding and developing effective strategies for these populations.

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主要人群对长效抗逆转录病毒药物预防和治疗的看法和意见:范围审查。

审查目的:重点人群受到人类免疫缺陷病毒(HIV)的不成比例的影响。在这些人群中，获取、保留和坚持是暴露前预防(PrEP)和艾滋病毒治疗效果的重要障碍。长效(LA)抗逆转录病毒药物有望解决其中一些问题。当前审查的目的是更新关键人群和PLWH对LA的看法，基于他们的意见，可接受性和使用它的意愿。最近的研究发现:根据综述，对LA的偏好因研究人群而异。关于艾滋病毒感染者(PLWH)，与男性发生性关系的男性对拥有不同的选择感兴趣，青少年对LA(植入物的强烈偏好)感兴趣，但也认为使用生物医学预防存在重大障碍;跨性别女性的目标是不可见的小型植入物，具有持久的效果，或者LA注射可以应用于臀部以外的其他部位，而有过医疗注射史的女性可能会增加对LA的偏好(注射吸毒者的历史除外[IDU])。女性性工作者和IDU都对LA-PrEP感兴趣。在抗逆转录病毒治疗方面，LA提高了治疗满意度和接受度，主要是在每2个月接受一次注射的患者中。洛杉矶帮助克服了药物疲劳、耻辱和依从性问题。摘要:了解对生物医学干预措施的偏好将有助于更好地了解和制定针对这些人群的有效策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in HIV and AIDS IMMUNOLOGY-INFECTIOUS DISEASES

CiteScore

7.40

自引率

7.30%

发文量

115

审稿时长

6-12 weeks

期刊介绍： Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in HIV and AIDS features hand-picked review articles from our team of expert editors. With six disciplines published across the year – including HIV and ageing, a HIV vaccine, and epidemiology – every issue also contains annotated reference detailing the merits of the most important papers.