Pulsed Electromagnetic Fields Improved Peripheral Nerve Regeneration After Delayed Repair of One Month

IF 1.8 3区生物学 Q3 BIOLOGY Bioelectromagnetics Pub Date : 2023-06-05 DOI:10.1002/bem.22443

Zhu Keyan, Zhang Liqian, Xu Xinzhong, Jing Juehua, Xu Chungui

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Abstract

The goal of this study was to determine if postoperative pulsed electromagnetic fields (PEMFs) could improve the neuromuscular rehabilitation after delayed repair of peripheral nerve injuries. Thirty‐six Sprague–Dawley rats were randomly divided into sham group, control group, and PEMFs group. The sciatic nerves were transected except for the control group. One month later, the nerve ends of the former two groups were reconnected. PEMFs group of rats was subjected to PEMFs thereafter. Control group and sham group received no treatment. Four and 8 weeks later, morphological and functional changes were measured. Four and eight weeks postoperatively, compared to sham group, the sciatic functional indices (SFIs) of PEMFs group were higher. More axons regenerated distally in PEMFs group. The fiber diameters of PEMFs group were larger. However, the axon diameters and myelin thicknesses were not different between these two groups. The brain‐derived neurotrophic factor and vascular endothelial growth factor expressions were higher in PEMFs group after 8 weeks. Semi‐quantitative IOD analysis for the intensity of positive staining indicated that there were more BDNF, VEGF, and NF200 in PEMFs group. It's concluded that PEMFs have effect on the axonal regeneration after delayed nerve repair of one month. The upregulated expressions of BDNF and VEGF may play roles in this process. © 2023 Bioelectromagnetics Society.

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脉冲电磁场对延迟修复1个月后周围神经再生的促进作用。

本研究的目的是确定脉冲电磁场(pemf)是否可以改善周围神经损伤延迟修复后的神经肌肉康复。将36只Sprague-Dawley大鼠随机分为假手术组、对照组和PEMFs组。除对照组外，其余均横断坐骨神经。一个月后，前两组的神经末梢重新连接。然后给予脉冲电磁场组大鼠进行脉冲电磁场治疗。对照组和假手术组均不进行治疗。4周和8周后，分别测定小鼠的形态和功能变化。术后4周和8周，与假手术组相比，PEMFs组的坐骨功能指数(sfi)较高。PEMFs组轴突远端再生较多。PEMFs组纤维直径较大。而轴突直径和髓鞘厚度在两组间无明显差异。8周后，PEMFs组脑源性神经营养因子和血管内皮生长因子表达升高。半定量IOD分析阳性染色强度显示，pemf组BDNF、VEGF、NF200表达增多。结论:pemf对延迟修复1个月后的神经轴突再生有一定的促进作用。BDNF和VEGF的表达上调可能参与了这一过程。©2023生物电磁学学会。

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来源期刊

Bioelectromagnetics 生物-生物物理

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Bioelectromagnetics is published by Wiley-Liss, Inc., for the Bioelectromagnetics Society and is the official journal of the Bioelectromagnetics Society and the European Bioelectromagnetics Association. It is a peer-reviewed, internationally circulated scientific journal that specializes in reporting original data on biological effects and applications of electromagnetic fields that range in frequency from zero hertz (static fields) to the terahertz undulations and visible light. Both experimental and clinical data are of interest to the journal''s readers as are theoretical papers or reviews that offer novel insights into or criticism of contemporary concepts and theories of field-body interactions. The Bioelectromagnetics Society, which sponsors the journal, also welcomes experimental or clinical papers on the domains of sonic and ultrasonic radiation.