Association between leukocyte telomere length and COVID-19 severity.

The Egyptian journal of medical human genetics Pub Date : 2023-01-01 Epub Date: 2023-05-29 DOI:10.1186/s43042-023-00415-z

Ata Mahmoodpoor, Sarvin Sanaie, Maqsoud Eskandari, Nazila Behrouzi, Majid Taghizadeh, Faranak Roudbari, Babak Emamalizadeh, Nasim Sohrabifar, Somayeh Kazeminasab

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Abstract

Background: Inter-individual variations in the clinical manifestations of SARS-CoV-2 infection are among the challenging features of COVID-19. The known role of telomeres in cell proliferation and immune competency highlights their possible function in infectious diseases. Variability in telomere length is an invaluable parameter in the heterogeneity of the clinical presentation of diseases.

Result: In this study, our aim was to investigate the possible association between leukocyte telomere length (LTL) and COVID-19 severity. LTL was measured in 100 patients with moderate and severe forms of COVID-19 using the quantitative PCR (q-PCR) method. Statistical analysis confirmed a strong inverse correlation between relative LTL and COVID-19 severity.

Conclusions: These findings suggest that LTL can be a useful parameter for predicting disease severity in patients, as individuals with short telomeres may have a higher risk of developing severe COVID-19.

Supplementary information: The online version contains supplementary material available at 10.1186/s43042-023-00415-z.

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白细胞端粒长度与新冠肺炎严重程度之间的关联。

背景：SARS-CoV-2感染临床表现的个体间变异是新冠肺炎的挑战性特征之一。端粒在细胞增殖和免疫能力中的已知作用突出了其在传染病中的可能功能。端粒长度的变异性是疾病临床表现异质性的一个宝贵参数。结果：在本研究中，我们的目的是研究白细胞端粒长度（LTL）与新冠肺炎严重程度之间的可能关联。使用定量PCR（q-PCR）方法对100例中重度新冠肺炎患者的LTL进行了测量。统计分析证实了相对LTL与新冠肺炎严重程度之间的强负相关。结论：这些发现表明，LTL可能是预测患者疾病严重程度的有用参数，因为端粒较短的个体可能有更高的发展严重COVID-19的风险。补充信息：在线版本包含补充材料，可在10.1186/s43042-023-00415-z上查到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Egyptian journal of medical human genetics

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