{"title":"[Statistical design and evaluation for clinical trials].","authors":"Y Wang, X Y Lang","doi":"10.3760/cma.j.cn112138-20230305-00134","DOIUrl":null,"url":null,"abstract":"临床试验的统计学设计多聚焦在样本量的计算过程，其核心是提出与临床设定相对应的统计学考虑，其中预期效应值的合理假设是决定试验规模的关键。而在试验的统计分析阶段，实际观察到的效应值决定了统计检验的结果，观察效应值与预期效应值间的对应程度，是决定试验结论和临床意义合理解读的基础。本文将就上述临床试验设计与评价阶段的关键方法学考虑进行介绍。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 6","pages":"594-596"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhonghua nei ke za zhi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/cma.j.cn112138-20230305-00134","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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