Engineering Strategies to Move from Understanding to Steering Renal Tubulogenesis.

IF 5.1 2区 医学 Q2 CELL & TISSUE ENGINEERING Tissue Engineering. Part B, Reviews Pub Date : 2023-06-01 DOI:10.1089/ten.TEB.2022.0120
Maria J Hagelaars, Laura Rijns, Patricia Y W Dankers, Sandra Loerakker, Carlijn V C Bouten
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引用次数: 1

Abstract

Rebuilding the kidney in the context of tissue engineering offers a major challenge as the organ is structurally complex and has a high variety of specific functions. Recreation of kidney function is inherently connected to the formation of tubules since the functional subunit of the kidney, the nephron, is based on tubular structures. In vivo, tubulogenesis culminates in a perfectly shaped, patterned, and functional renal tubule via different morphogenic processes that depend on delicately orchestrated chemical, physical, and mechanical interactions between cells and between cells and their microenvironment. This review summarizes the current understanding of the role of the microenvironment in the morphogenic processes involved in in vivo renal tubulogenesis. We highlight the current state-of-the-art of renal tubular engineering and provide a view on the design elements that can be extracted from these studies. Next, we discuss how computational modeling can aid in specifying and identifying design parameters and provide directions on how these design parameters can be incorporated in biomaterials for the purpose of engineering renal tubulogenesis. Finally, we propose that a step-by-step reciprocal interaction between understanding and engineering is necessary to effectively guide renal tubulogenesis. Impact statement Tubular tissue engineering lies at the foundation of regenerating kidney tissue function, as the functional subunit of the kidney, the nephron, is based on tubular structures. Guiding renal tubulogenesis toward functional renal tubules requires in-depth knowledge of the developmental processes that lead to the formation of native tubules as well as engineering approaches to steer these processes. In this study, we review the role of the microenvironment in the developmental processes that lead to functional renal tubules and give directions how this knowledge can be harnessed for biomaterial-based tubular engineering using computational models.

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从理解到指导肾小管形成的工程策略。
在组织工程的背景下,重建肾脏是一个重大的挑战,因为器官结构复杂,具有多种特定的功能。肾脏功能的恢复与肾小管的形成有着内在的联系,因为肾脏的功能亚单位肾元是基于肾小管结构的。在体内,肾小管的形成通过不同的形态形成过程,最终形成形状、图案和功能完美的肾小管,这些过程依赖于细胞之间以及细胞与微环境之间精细的化学、物理和机械相互作用。本文综述了目前对微环境在体内肾小管形成的形态发生过程中的作用的理解。我们强调了当前肾小管工程的最新技术,并提供了可以从这些研究中提取的设计元素的观点。接下来,我们将讨论计算建模如何帮助指定和识别设计参数,并就如何将这些设计参数纳入生物材料中以实现工程肾小管形成提供指导。最后,我们建议理解和工程之间的一步一步的相互作用是必要的,以有效地指导肾小管形成。肾管组织工程是肾组织功能再生的基础,肾的功能亚单位肾元是基于肾管结构的。引导肾小管向功能性肾小管的形成需要深入了解导致天然小管形成的发育过程,以及引导这些过程的工程方法。在本研究中,我们回顾了微环境在导致肾小管功能的发育过程中的作用,并给出了如何利用计算模型将这些知识用于基于生物材料的肾小管工程的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tissue Engineering. Part B, Reviews
Tissue Engineering. Part B, Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
12.80
自引率
1.60%
发文量
150
期刊介绍: Tissue Engineering Reviews (Part B) meets the urgent need for high-quality review articles by presenting critical literature overviews and systematic summaries of research within the field to assess the current standing and future directions within relevant areas and technologies. Part B publishes bi-monthly.
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