RNAs as Sensors of Oxidative Stress in Bacteria.

IF 7.6 2区 工程技术 Q1 CHEMISTRY, APPLIED Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 DOI:10.1146/annurev-chembioeng-101121-070250
Ryan Buchser, Phillip Sweet, Aparna Anantharaman, Lydia Contreras
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Abstract

Oxidative stress is an important and pervasive physical stress encountered by all kingdoms of life, including bacteria. In this review, we briefly describe the nature of oxidative stress, highlight well-characterized protein-based sensors (transcription factors) of reactive oxygen species that serve as standards for molecular sensors in oxidative stress, and describe molecular studies that have explored the potential of direct RNA sensitivity to oxidative stress. Finally, we describe the gaps in knowledge of RNA sensors-particularly regarding the chemical modification of RNA nucleobases. RNA sensors are poised to emerge as an essential layer of understanding and regulating dynamic biological pathways in oxidative stress responses in bacteria and, thus, also represent an important frontier of synthetic biology.

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作为细菌氧化应激传感器的 RNA。
氧化应激是包括细菌在内的所有生物界都会遇到的一种重要而普遍的物理应激。在这篇综述中,我们简要描述了氧化应激的性质,重点介绍了作为氧化应激分子传感器标准的、以蛋白质为基础的活性氧传感器(转录因子),并介绍了探索 RNA 对氧化应激的直接敏感性的分子研究。最后,我们介绍了有关 RNA 传感器的知识缺口,特别是有关 RNA 核碱基化学修饰的知识缺口。RNA 传感器有望成为了解和调节细菌氧化应激反应中动态生物通路的一个重要层面,因此也是合成生物学的一个重要前沿领域。
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来源期刊
Annual review of chemical and biomolecular engineering
Annual review of chemical and biomolecular engineering CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL
CiteScore
16.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Chemical and Biomolecular Engineering aims to provide a perspective on the broad field of chemical (and related) engineering. The journal draws from disciplines as diverse as biology, physics, and engineering, with development of chemical products and processes as the unifying theme.
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