Networks of C-reactive protein and depression symptoms in patients with stable coronary heart disease: Findings from the Heart and Soul Study

IF 2.4 3区医学 Q2 PSYCHIATRY International Journal of Methods in Psychiatric Research Pub Date : 2023-04-10 DOI:10.1002/mpr.1968

Chiyoung Lee, Mary A. Whooley

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Abstract

Objective

Research addressing the associations between C-reactive protein (CRP) and depression among patients with stable coronary heart disease (CHD) has produced inconsistent results. This might be attributable to varying associations of CRP with specific depression symptom profiles. We responded to this challenge using various network analysis techniques.

Methods

A total of 967 outpatients with documented CHD were drawn from the baseline cross-sectional data of the Heart and Soul Study. We first estimated mixed graphical models that included CRP and individual depression symptoms, before and after adjusting for relevant covariates, to explore whether CRP is correlated with specific facets of depression. We also investigated whether CRP levels moderated the associations between specific depression symptoms using moderated network models. Finally, we performed a network comparison test and compared the symptom network properties between non-elevated and elevated CRP groups.

Results

In the network model without covariates, CRP was positively associated with fatigue, appetite changes, and psychomotor problems. CRP maintained its negative association with concentration difficulty regardless of covariate adjustment. Few symptom-symptom associations, especially those involving appetite changes, were moderated by CRP. Further, the elevated CRP group showed greater overall symptom connectivity as compared to the non-elevated group.

Conclusion

This study segues into CRP-depression relationship with sophisticated methodology.

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稳定型冠心病患者的c反应蛋白网络与抑郁症状:来自心脏与灵魂研究的发现

目的:研究稳定型冠心病(CHD)患者c反应蛋白(CRP)与抑郁之间的关系，结果不一致。这可能归因于CRP与特定抑郁症状的不同关联。我们使用各种网络分析技术来应对这一挑战。方法:从心脏与灵魂研究的基线横断面数据中抽取967例有记录的冠心病门诊患者。我们首先估计了包括CRP和个体抑郁症状的混合图形模型，在调整相关协变量之前和之后，以探索CRP是否与抑郁症的特定方面相关。我们还使用调节网络模型研究了CRP水平是否能调节特定抑郁症状之间的关联。最后，我们进行了网络比较测试，比较了CRP未升高组和CRP升高组之间的症状网络特性。结果:在无协变量的网络模型中，CRP与疲劳、食欲变化和精神运动问题呈正相关。无论协变量调整如何，CRP与浓度困难保持负相关。很少有症状-症状的关联，尤其是那些涉及食欲变化的，被CRP所缓和。此外，与非升高组相比，CRP升高组表现出更大的整体症状连通性。结论:本研究采用完善的研究方法，深入探讨了crp与抑郁的关系。

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来源期刊

International Journal of Methods in Psychiatric Research 医学-精神病学

CiteScore

5.20

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： The International Journal of Methods in Psychiatric Research (MPR) publishes high-standard original research of a technical, methodological, experimental and clinical nature, contributing to the theory, methodology, practice and evaluation of mental and behavioural disorders. The journal targets in particular detailed methodological and design papers from major national and international multicentre studies. There is a close working relationship with the US National Institute of Mental Health, the World Health Organisation (WHO) Diagnostic Instruments Committees, as well as several other European and international organisations. MPR aims to publish rapidly articles of highest methodological quality in such areas as epidemiology, biostatistics, generics, psychopharmacology, psychology and the neurosciences. Articles informing about innovative and critical methodological, statistical and clinical issues, including nosology, can be submitted as regular papers and brief reports. Reviews are only occasionally accepted. MPR seeks to monitor, discuss, influence and improve the standards of mental health and behavioral neuroscience research by providing a platform for rapid publication of outstanding contributions. As a quarterly journal MPR is a major source of information and ideas and is an important medium for students, clinicians and researchers in psychiatry, clinical psychology, epidemiology and the allied disciplines in the mental health field.