Salameh, P., J. El Khoury, M. Hallal, et al. 2025. “Body Dysmorphic Disorder Questionnaire: Arabic Adaptation and Validation in Dermatology Population”, International Journal of Methods in Psychiatric Research, 34, no. 4: e70045. https://doi.org/10.1002/mpr.70045.
Table 1 and Table 2 were initially published with formatting errors. The published article has now been updated to display the correct formatting.
In paragraph 4 of the Discussion section, the citations of two references were incorrectly reversed. They have now been corrected and appear in the proper order in the published article.
We apologize for these errors.
Salameh， P.， J. El Khoury， M. Hallal等。2025。“身体畸形障碍问卷：皮肤病学人群的阿拉伯语适应和验证”，《国际精神病学研究方法杂志》，第34期。4: e70045。https://doi.org/10.1002/mpr.70045.Table 1和表2最初发布时存在格式错误。已发布的文章现在已经更新以显示正确的格式。在讨论部分第4段中，有两个参考文献的引文被错误地颠倒了。它们现在已被更正，并按正确的顺序出现在已发表的文章中。我们为这些错误道歉。
{"title":"Correction to “Body Dysmorphic Disorder Questionnaire: Arabic Adaptation and Validation in Dermatology Population”","authors":"","doi":"10.1002/mpr.70059","DOIUrl":"10.1002/mpr.70059","url":null,"abstract":"<p>Salameh, P., J. El Khoury, M. Hallal, et al. 2025. “Body Dysmorphic Disorder Questionnaire: Arabic Adaptation and Validation in Dermatology Population”, <i>International Journal of Methods in Psychiatric Research</i>, 34, no. 4: e70045. https://doi.org/10.1002/mpr.70045.</p><p>Table 1 and Table 2 were initially published with formatting errors. The published article has now been updated to display the correct formatting.</p><p>In paragraph 4 of the Discussion section, the citations of two references were incorrectly reversed. They have now been corrected and appear in the proper order in the published article.</p><p>We apologize for these errors.</p>","PeriodicalId":50310,"journal":{"name":"International Journal of Methods in Psychiatric Research","volume":"35 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vera Birgel, Michael Rapp, Mira Tschorn, Heike Hölling, Caroline Cohrdes
Objectives
This study examines the continuity and comparability of internalizing and externalizing symptom spectra from adolescence to young adulthood, addressing measurement challenges across developmental stages. Leveraging the Hierarchical Taxonomy of Psychopathology (HiTOP) framework, it explores whether symptom spectra in adolescence predict corresponding symptoms in young adulthood.
Methods
Data were drawn from JEPSY, a follow-up of the national KiGGS cohort (N = 2172, age 18–26). Adolescent internalizing and externalizing symptoms were assessed via the Strengths and Difficulties Questionnaire (SDQ) and substance use items. Adult outcomes included the Patient Health Questionnaire (PHQ-4), DSM-5 Cross-Cutting Symptom Measure (DSM-5 CC), and Personality Inventory for DSM-5 (PID-5). Factor analyses assessed structural consistency, and robust regression examined associations between adolescent and adult symptom spectra over 7–10 years.
Results
A four-factor model best captured the SDQ structure. In young adulthood, three spectra emerged: internalizing symptoms, externalizing traits, and substance use. Adolescent emotional and peer problems predicted internalizing symptoms in adulthood. Conduct problems and hyperactivity predicted externalizing traits. Substance use was associated with hyperactivity, smoking, and risky drinking—but negatively with peer problems.
Conclusion
The findings support the continuity of broad psychopathological spectra and demonstrate that harmonized approaches can bridge measurement gaps and enhance longitudinal comparability.
{"title":"Development and Comparability of Internalizing and Externalizing Symptom Spectra From Adolescence to Young Adulthood","authors":"Vera Birgel, Michael Rapp, Mira Tschorn, Heike Hölling, Caroline Cohrdes","doi":"10.1002/mpr.70055","DOIUrl":"10.1002/mpr.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study examines the continuity and comparability of internalizing and externalizing symptom spectra from adolescence to young adulthood, addressing measurement challenges across developmental stages. Leveraging the Hierarchical Taxonomy of Psychopathology (HiTOP) framework, it explores whether symptom spectra in adolescence predict corresponding symptoms in young adulthood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were drawn from JEPSY, a follow-up of the national KiGGS cohort (<i>N</i> = 2172, age 18–26). Adolescent internalizing and externalizing symptoms were assessed via the Strengths and Difficulties Questionnaire (SDQ) and substance use items. Adult outcomes included the Patient Health Questionnaire (PHQ-4), DSM-5 Cross-Cutting Symptom Measure (DSM-5 CC), and Personality Inventory for DSM-5 (PID-5). Factor analyses assessed structural consistency, and robust regression examined associations between adolescent and adult symptom spectra over 7–10 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A four-factor model best captured the SDQ structure. In young adulthood, three spectra emerged: internalizing symptoms, externalizing traits, and substance use. Adolescent emotional and peer problems predicted internalizing symptoms in adulthood. Conduct problems and hyperactivity predicted externalizing traits. Substance use was associated with hyperactivity, smoking, and risky drinking—but negatively with peer problems.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings support the continuity of broad psychopathological spectra and demonstrate that harmonized approaches can bridge measurement gaps and enhance longitudinal comparability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50310,"journal":{"name":"International Journal of Methods in Psychiatric Research","volume":"35 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12820720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Margreet Ten Have, Marlous Tuithof, Premysl Velek, Saskia Van Dorsselaer, Simone Korteling, Brenda W. J. H. Penninx, Annemarie I. Luik
Objectives
Longitudinal studies that visualise individual trajectories of depressive and/or anxiety disorders can inform prevention and treatment strategies.
Methods
Participants of the Netherlands Mental Health Survey and Incidence Study (NEMESIS) were assessed at four timepoints from 2007–2009 to 2016–2018 (N = 6646 at baseline). DSM-IV disorders were assessed using the Composite International Diagnostic Interview. Onset and course trajectories were visualised with Sankey diagrams and summarised in incidence, remission, recurrence, and persistency rates, considering presence of any depressive or anxiety disorder as outcome.
Results
Among those without a lifetime depressive or anxiety disorder at baseline, 13% developed a depressive and/or anxiety disorder over 9 years, with higher rates in women and younger adults. Recurrence rates over 9 years were 28% for depressive, 26% for anxiety, and 38% for comorbid disorders. For those with a current disorder at baseline, recurrence (including persistence) was 33%, 31%, and 51%, respectively. Course trajectories were similar across sexes but less favourable for younger adults with a disorder history.
Conclusions
Between 31% and 51% of persons with a current depressive and/or anxiety disorder do not remit over 9 years. This highlights the need for long-term treatment strategies, including ongoing monitoring, management, and relapse prevention.
{"title":"The Onset, Course and Co-Occurrence of Depressive and Anxiety Disorders Over a 9-Year Period in the General Population","authors":"Margreet Ten Have, Marlous Tuithof, Premysl Velek, Saskia Van Dorsselaer, Simone Korteling, Brenda W. J. H. Penninx, Annemarie I. Luik","doi":"10.1002/mpr.70054","DOIUrl":"10.1002/mpr.70054","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Longitudinal studies that visualise individual trajectories of depressive and/or anxiety disorders can inform prevention and treatment strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants of the Netherlands Mental Health Survey and Incidence Study (NEMESIS) were assessed at four timepoints from 2007–2009 to 2016–2018 (<i>N</i> = 6646 at baseline). DSM-IV disorders were assessed using the Composite International Diagnostic Interview. Onset and course trajectories were visualised with Sankey diagrams and summarised in incidence, remission, recurrence, and persistency rates, considering presence of any depressive or anxiety disorder as outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among those without a lifetime depressive or anxiety disorder at baseline, 13% developed a depressive and/or anxiety disorder over 9 years, with higher rates in women and younger adults. Recurrence rates over 9 years were 28% for depressive, 26% for anxiety, and 38% for comorbid disorders. For those with a current disorder at baseline, recurrence (including persistence) was 33%, 31%, and 51%, respectively. Course trajectories were similar across sexes but less favourable for younger adults with a disorder history.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Between 31% and 51% of persons with a current depressive and/or anxiety disorder do not remit over 9 years. This highlights the need for long-term treatment strategies, including ongoing monitoring, management, and relapse prevention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50310,"journal":{"name":"International Journal of Methods in Psychiatric Research","volume":"35 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruaa Raoof Hussein Al-Sultan, Shatha Mohammed Jasim, Faris Lami, Osamah Abbas Jaber, Nahid Dehghan Nayeri, Mahdi Shafiee Sabet, Ghaith Al-Gburi
Objectives
Comprehensive scales should be used to better understand the patterns of restrictive and repetitive behaviours in children with autism spectrum disorder in middle and lower-income countries. This study aimed to validate an Arabic translation of the revised Repetitive Behaviours Scale.
Methods
Parents of 258 children were interviewed in a cross-sectional study conducted at Al-Subtain Academy from December 1, 2023, to August 1, 2024. The R Language and Environment for Statistical Programing v4.4.2 was utilised for statistical analysis.
Results
Following confirmatory factor analysis, the 6-factor solution was selected for further testing based on more favourable fitness indices and the 2-factor solution was selected based on an acceptable RMSEA of 0.064 and evidence of cross-cultural validity from previous validations. The 2-factor solution demonstrated better subscales' reliability, with composite coefficients of 0.801 and 0.908, and corrected item-total correlations that are more consistent with the theoretical framework for the scale. A modification for this model was suggested based on item performance and demonstrated a marginal improvement in the CFI and TLI indices.
Conclusion
The Arabic revised repetitive behaviours scale demonstrates a valid and reliable structure, aligning with the conceptual classification of repetitive and restrictive behaviours into repetitive sensory-motor behaviours and insistence on sameness.
{"title":"Translation and Validation of the Arabic Version of the Revised Restrictive Behaviours Scale Among Iraqi Children With Autism Spectrum Disorder: A Suggestion for Model Modification","authors":"Ruaa Raoof Hussein Al-Sultan, Shatha Mohammed Jasim, Faris Lami, Osamah Abbas Jaber, Nahid Dehghan Nayeri, Mahdi Shafiee Sabet, Ghaith Al-Gburi","doi":"10.1002/mpr.70048","DOIUrl":"10.1002/mpr.70048","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Comprehensive scales should be used to better understand the patterns of restrictive and repetitive behaviours in children with autism spectrum disorder in middle and lower-income countries. This study aimed to validate an Arabic translation of the revised Repetitive Behaviours Scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Parents of 258 children were interviewed in a cross-sectional study conducted at Al-Subtain Academy from December 1, 2023, to August 1, 2024. The <i>R</i> Language and Environment for Statistical Programing v4.4.2 was utilised for statistical analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Following confirmatory factor analysis, the 6-factor solution was selected for further testing based on more favourable fitness indices and the 2-factor solution was selected based on an acceptable RMSEA of 0.064 and evidence of cross-cultural validity from previous validations. The 2-factor solution demonstrated better subscales' reliability, with composite coefficients of 0.801 and 0.908, and corrected item-total correlations that are more consistent with the theoretical framework for the scale. A modification for this model was suggested based on item performance and demonstrated a marginal improvement in the CFI and TLI indices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The Arabic revised repetitive behaviours scale demonstrates a valid and reliable structure, aligning with the conceptual classification of repetitive and restrictive behaviours into repetitive sensory-motor behaviours and insistence on sameness.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50310,"journal":{"name":"International Journal of Methods in Psychiatric Research","volume":"34 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12745494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mais Najah Razak Al-Shibly, Ali Hussein AlHusseiny, Faris Lami, Shatha Mohammed Jasim, Osamah Abbas Jaber, Nahid Dehghan Nayeri, Mahdi Shafiee Sabet, Ghaith Al-Gburi
Objectives
In middle- and lower-income countries, the scarcity of psychiatric expertise and IQ testing should be considered when developing and testing assessment tools. This study aims to assess the psychometric properties of a modified Arabic version of the Childhood Autism Rating Scale 2 Standard Form.
Methods
A diagnostic accuracy study, including 286 children, was conducted from December 1, 2023, to August 1, 2024, at Baghdad's National Centre and Al-Subtain Academy for Autism. Confirmatory factor analysis was utilized for structural validity, standardized alpha and the average inter-item correlation for reliability, and ROC curve analysis for diagnostic accuracy.
Results
Good fit was demonstrated for the 1-, 2-, and 3-factor solutions. In all models, ‘activity levels’ had the lowest loadings and higher scores in children with ADHD (p-value = 0.0002). Excellent internal consistency was shown with a standardised alpha of 0.90 (> 0.7) and an average inter-item correlation of 0.394 (> 0.15). At the optimal cut-off (≥ 28.5), the scale had a sensitivity of 82.6%, a specificity of 93.4%, and would increase the child's odds of having ASD by 12.5.
Conclusion
The modified scale has good psychometric properties and might be utilised to adjust the psychiatric evaluation of children suspected of having a neurodevelopmental disorder.
{"title":"Psychometric Properties of an Arabic Modified Childhood Autism Rating Scale 2 Standard Form","authors":"Mais Najah Razak Al-Shibly, Ali Hussein AlHusseiny, Faris Lami, Shatha Mohammed Jasim, Osamah Abbas Jaber, Nahid Dehghan Nayeri, Mahdi Shafiee Sabet, Ghaith Al-Gburi","doi":"10.1002/mpr.70047","DOIUrl":"10.1002/mpr.70047","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>In middle- and lower-income countries, the scarcity of psychiatric expertise and IQ testing should be considered when developing and testing assessment tools. This study aims to assess the psychometric properties of a modified Arabic version of the Childhood Autism Rating Scale 2 Standard Form.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A diagnostic accuracy study, including 286 children, was conducted from December 1, 2023, to August 1, 2024, at Baghdad's National Centre and Al-Subtain Academy for Autism. Confirmatory factor analysis was utilized for structural validity, standardized alpha and the average inter-item correlation for reliability, and ROC curve analysis for diagnostic accuracy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Good fit was demonstrated for the 1-, 2-, and 3-factor solutions. In all models, ‘activity levels’ had the lowest loadings and higher scores in children with ADHD (<i>p</i>-value = 0.0002). Excellent internal consistency was shown with a standardised alpha of 0.90 (> 0.7) and an average inter-item correlation of 0.394 (> 0.15). At the optimal cut-off (≥ 28.5), the scale had a sensitivity of 82.6%, a specificity of 93.4%, and would increase the child's odds of having ASD by 12.5.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The modified scale has good psychometric properties and might be utilised to adjust the psychiatric evaluation of children suspected of having a neurodevelopmental disorder.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50310,"journal":{"name":"International Journal of Methods in Psychiatric Research","volume":"34 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12717145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jayne Pickering, Wen Shao, Scott Weich, Caroline F. Dalton, Myles Jones, Chris D. J. Taylor, Markus Reuber, Jessica Kingston, Chris Gibbs, Richard P. Bentall
Objectives
Early identification of individuals at risk for developing mental health disorders is critical for timely intervention, reducing distress and improving outcomes. This study outlines the development and preliminary validation of ‘TRACE’, a short self-report measure designed to detect a pluripotent at-risk mental state (PARMS). The measure captures a range of subthreshold symptoms and traits associated with emerging manifestations of mania, psychosis and borderline personality disorder.
Methods
A sample of 2037 general-population adolescents and young adults (aged 14–36) completed TRACE questions and other psychometrics.
Results
Exploratory Graph Analysis, undertaken on one-half of the dataset, generated a three-factor structure that was successfully replicated in the other half of the data, via confirmatory factor analysis. The final 26-item scale has acceptable model fit (with a scaled CFI of 0.93, TLI of 0.92, with acceptable-to-good error, RMSEA of 0.073) and good concurrent validity with other relevant psychometrics, such as neuroticism and loneliness (r = 0.29 and 0.43, respectively).
Conclusion
These findings suggest that the tool may be useful in identifying individuals with a broad, pluripotent vulnerability to develop severe mental health disorders. Future research will focus on validating the tool longitudinally and across diverse populations to assess its predictive utility and clinical value.
{"title":"Developing Trace: A Transdiagnostic Screening Tool for Early Detection of a Pluripotent at-Risk Mental State","authors":"Jayne Pickering, Wen Shao, Scott Weich, Caroline F. Dalton, Myles Jones, Chris D. J. Taylor, Markus Reuber, Jessica Kingston, Chris Gibbs, Richard P. Bentall","doi":"10.1002/mpr.70046","DOIUrl":"10.1002/mpr.70046","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Early identification of individuals at risk for developing mental health disorders is critical for timely intervention, reducing distress and improving outcomes. This study outlines the development and preliminary validation of ‘TRACE’, a short self-report measure designed to detect a pluripotent at-risk mental state (PARMS). The measure captures a range of subthreshold symptoms and traits associated with emerging manifestations of mania, psychosis and borderline personality disorder.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A sample of 2037 general-population adolescents and young adults (aged 14–36) completed TRACE questions and other psychometrics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Exploratory Graph Analysis, undertaken on one-half of the dataset, generated a three-factor structure that was successfully replicated in the other half of the data, via confirmatory factor analysis. The final 26-item scale has acceptable model fit (with a scaled CFI of 0.93, TLI of 0.92, with acceptable-to-good error, RMSEA of 0.073) and good concurrent validity with other relevant psychometrics, such as neuroticism and loneliness (<i>r</i> = 0.29 and 0.43, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that the tool may be useful in identifying individuals with a broad, pluripotent vulnerability to develop severe mental health disorders. Future research will focus on validating the tool longitudinally and across diverse populations to assess its predictive utility and clinical value.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50310,"journal":{"name":"International Journal of Methods in Psychiatric Research","volume":"34 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12675136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jurriaan F. M. Strous, Gijs H. J. Roelandt, Jens H. van Dalfsen, Jeanine Kamphuis, Radboud M. Marijnissen, Robert A. Schoevers
Background
Suicidality is a transdiagnostic entity in patients with and without psychiatric disorders. Ketamine is a novel treatment for treatment-resistant depression with favorable effects on related suicidality in this population. Little is known about the effects of ketamine on suicidality as a distinct phenomenon.
Objective
To assess whether a dose of 75 mg intranasal (IN) ketamine reduces acute suicidality relative to a 4 mg intranasal dose of the active placebo midazolam, 180 min after administration.
Methods/design
A double-blind randomized placebo-controlled trial (N = 100) will assess the efficacy of fixed-dose IN racemic ketamine in patients presenting with acute suicidality, regardless of psychiatric diagnosis. Participants receive a single IN dose of either racemic ketamine (75 mg) or midazolam (4 mg) along with treatment as usual. The primary outcome is the reduction in suicidal ideation as measured by the Beck Scale for Suicide Ideation (BSSI) at 180 min. Secondary outcomes include depression severity with the Montgomery Åsberg Depression Rating Scale (MADRS) and tolerability with the Systematic Assessment for Treatment Emerging Effects (SAFTEE) as well as blood-based and neuroimaging markers.
Discussion
This study design considers key aspects such as patient selection, ketamine formulation, clinical management, and the follow-up time points. Potential risks, limitations, and future considerations are additionally discussed.
{"title":"The Ketamine Trial for Acute Suicidality (KETA): Study Protocol of a Double-Blind Randomized Placebo-Controlled Superiority Trial on Intranasal Racemic Ketamine Compared to the Active Placebo Intranasal Midazolam as Treatment for Acute Suicidality","authors":"Jurriaan F. M. Strous, Gijs H. J. Roelandt, Jens H. van Dalfsen, Jeanine Kamphuis, Radboud M. Marijnissen, Robert A. Schoevers","doi":"10.1002/mpr.70044","DOIUrl":"10.1002/mpr.70044","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Suicidality is a transdiagnostic entity in patients with and without psychiatric disorders. Ketamine is a novel treatment for treatment-resistant depression with favorable effects on related suicidality in this population. Little is known about the effects of ketamine on suicidality as a distinct phenomenon.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess whether a dose of 75 mg intranasal (IN) ketamine reduces acute suicidality relative to a 4 mg intranasal dose of the active placebo midazolam, 180 min after administration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods/design</h3>\u0000 \u0000 <p>A double-blind randomized placebo-controlled trial (<i>N</i> = 100) will assess the efficacy of fixed-dose IN racemic ketamine in patients presenting with acute suicidality, regardless of psychiatric diagnosis. Participants receive a single IN dose of either racemic ketamine (75 mg) or midazolam (4 mg) along with treatment as usual. The primary outcome is the reduction in suicidal ideation as measured by the Beck Scale for Suicide Ideation (BSSI) at 180 min. Secondary outcomes include depression severity with the Montgomery Åsberg Depression Rating Scale (MADRS) and tolerability with the Systematic Assessment for Treatment Emerging Effects (SAFTEE) as well as blood-based and neuroimaging markers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>This study design considers key aspects such as patient selection, ketamine formulation, clinical management, and the follow-up time points. Potential risks, limitations, and future considerations are additionally discussed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>EudraCT 2020-002905-24, registered 6 October 2021</p>\u0000 </section>\u0000 </div>","PeriodicalId":50310,"journal":{"name":"International Journal of Methods in Psychiatric Research","volume":"34 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12627964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145551668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jie Luo, Wen Shao, Yuanzhen Wu, Huanhuan Huang, Gaoyang Xu, Yanjie Qi, Paul Overton, Yi Zheng, Fan He
Objective
This study aimed to explore the transdiagnostic interactions between ADHD and ASD symptoms in Chinese children, identifying core and bridging symptoms, and examining differences in symptom networks across gender and age subgroups.
Method
Using data from a nationwide mental health survey of 71,217 Chinese children (mean age = 11.49, SD = 2.82), a symptom network analysis was conducted. ADHD and ASD symptoms were assessed via the Child Behavior Checklist (CBCL), with ASD items selected from an empirically derived CBCL autism scale. Network estimation was performed using the Glasso algorithm, and community detection was achieved through exploratory graph analysis (EGA). Network comparison tests (NCT) were used to evaluate differences in network structure and connectivity between gender (male vs. female) and age (younger vs. older) subgroups.
Results
Inattentive symptoms (I8 “Cannot concentrate,” I78 “Inattentive/easily distracted”) emerged as central bridging nodes linking ADHD and ASD symptoms. Three stable communities were identified: (1) an inattentive/internalizing cluster reflecting overlapping ADHD-inattentive and ASD features, (2) a hyperactive/impulsive and immature behavior cluster, and (3) a social withdrawal/low energy cluster representing core ASD features. Females exhibited significantly higher network connectivity than males (global strength: S = 1.05, p = 0.03), with tighter symptom interplay. Older children showed greater ADHD-ASD symptom overlap, though global strength differences were non-significant (S = 0.70, p = 0.13).
Conclusion
Two inattentive symptoms (I8 and I78) emerged as among the most strongly connected items in the combined ADHD–ASD symptom profile, suggesting that attentional difficulties could play an important role in the psychopathological mechanisms underlying both conditions. Nevertheless, this cross-sectional finding does not establish causality; longitudinal and intervention studies remain necessary. Screening approaches tailored to gender differences and local cultural context could improve identification of these symptoms in Chinese children and adolescents. The present findings may also guide future refinements in school mental-health support and related policy development.
目的：本研究旨在探讨中国儿童ADHD和ASD症状之间的跨诊断相互作用，识别核心症状和桥接症状，并检查不同性别和年龄亚组之间症状网络的差异。方法：利用全国71217名儿童（平均年龄11.49岁，SD = 2.82）的心理健康调查数据，进行症状网络分析。ADHD和ASD症状通过儿童行为检查表（CBCL）进行评估，其中ASD项目从经验导出的CBCL自闭症量表中选择。使用Glasso算法进行网络估计，通过探索性图分析（exploratory graph analysis， EGA）实现社区检测。使用网络比较测试（NCT）来评估性别（男性与女性）和年龄（年轻与年长）亚组之间网络结构和连通性的差异。结果：注意力不集中症状（I8“不能集中注意力”，I78“注意力不集中/容易分心”）成为连接ADHD和ASD症状的中心桥梁节点。研究发现了三个稳定的群体：(1)注意力不集中/内化群体，反映了adhd -不集中和ASD特征的重叠；(2)多动/冲动和不成熟行为群体；(3)社会退缩/低能量群体，代表了ASD的核心特征。女性的网络连通性显著高于男性（整体强度：S = 1.05, p = 0.03），症状相互作用更紧密。年龄较大的儿童表现出更多的ADHD-ASD症状重叠，尽管整体强度差异不显著（S = 0.70, p = 0.13）。结论：两个注意力不集中症状（I8和I78）是ADHD-ASD合并症状谱中联系最紧密的项目，提示注意困难可能在ADHD-ASD合并症状的精神病理机制中发挥重要作用。然而，这一横断面研究结果并不能确定因果关系；纵向和干预研究仍然是必要的。针对性别差异和当地文化背景量身定制的筛查方法可以提高对中国儿童和青少年这些症状的识别。本研究结果也可以指导未来学校心理健康支持和相关政策的制定。
{"title":"A Network Analysis of ADHD and ASD Symptoms in Chinese Children: Insights on Age and Gender Differences","authors":"Jie Luo, Wen Shao, Yuanzhen Wu, Huanhuan Huang, Gaoyang Xu, Yanjie Qi, Paul Overton, Yi Zheng, Fan He","doi":"10.1002/mpr.70042","DOIUrl":"10.1002/mpr.70042","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to explore the transdiagnostic interactions between ADHD and ASD symptoms in Chinese children, identifying core and bridging symptoms, and examining differences in symptom networks across gender and age subgroups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Using data from a nationwide mental health survey of 71,217 Chinese children (mean age = 11.49, SD = 2.82), a symptom network analysis was conducted. ADHD and ASD symptoms were assessed via the Child Behavior Checklist (CBCL), with ASD items selected from an empirically derived CBCL autism scale. Network estimation was performed using the Glasso algorithm, and community detection was achieved through exploratory graph analysis (EGA). Network comparison tests (NCT) were used to evaluate differences in network structure and connectivity between gender (male vs. female) and age (younger vs. older) subgroups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Inattentive symptoms (I8 “Cannot concentrate,” I78 “Inattentive/easily distracted”) emerged as central bridging nodes linking ADHD and ASD symptoms. Three stable communities were identified: (1) an inattentive/internalizing cluster reflecting overlapping ADHD-inattentive and ASD features, (2) a hyperactive/impulsive and immature behavior cluster, and (3) a social withdrawal/low energy cluster representing core ASD features. Females exhibited significantly higher network connectivity than males (global strength: <i>S</i> = 1.05, <i>p</i> = 0.03), with tighter symptom interplay. Older children showed greater ADHD-ASD symptom overlap, though global strength differences were non-significant (<i>S</i> = 0.70, <i>p</i> = 0.13).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Two inattentive symptoms (I8 and I78) emerged as among the most strongly connected items in the combined ADHD–ASD symptom profile, suggesting that attentional difficulties could play an important role in the psychopathological mechanisms underlying both conditions. Nevertheless, this cross-sectional finding does not establish causality; longitudinal and intervention studies remain necessary. Screening approaches tailored to gender differences and local cultural context could improve identification of these symptoms in Chinese children and adolescents. The present findings may also guide future refinements in school mental-health support and related policy development.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50310,"journal":{"name":"International Journal of Methods in Psychiatric Research","volume":"34 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12627236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145551673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Body Dysmorphic Disorder (BDD) is a psychiatric condition characterized by excessive preoccupation with perceived flaws in physical appearance, often encountered in dermatologic settings.
Objective
This study aims to validate the Arabic Body Dysmorphic Disorder Questionnaire (BDDQ), used in the dermatologic setting.
Methods
Using previous versions of BDDQ, we developed a scale that considers the dermatologic setting and conditions and translated it into Arabic. The new tool was assessed for its construct, structural, and criterion validity and reliability.
Results
The newly developed tool had an appropriate construct validity; it was unidimensional (57% variance explanation), with excellent internal consistency (Cronbach alpha = 0.889). The structural (significant inter-item and item-scale Spearman correlation coefficients) and criterion validity measures (AUC = 0.869) were also appropriate. Compared to a physician diagnosis of BDD, two cut-off values were defined for the scale: 11.5 for screening purposes (Se = 100%; Sp = 31%), and 18.5 for diagnostic purposes (Se = 83% and Sp = 83.5%).
Conclusion
This study developed and validated a quantitative scale in a dermatology setting, the Arabic BDDQ scale. Further studies are recommended to confirm the scale's efficiency for screening and diagnostic purposes.
{"title":"Body Dysmorphic Disorder Questionnaire: Arabic Adaptation and Validation in Dermatology Population","authors":"Pascale Salameh, Jinane El Khoury, Marwa Hallal, Elissa Bader, Raneem Abed El Sater, Micheline Maamari, Maya Habre, Rami Abadi, Grace Obeid, Jihane Abou Rahal, Rudy Abi-Habib","doi":"10.1002/mpr.70045","DOIUrl":"10.1002/mpr.70045","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Body Dysmorphic Disorder (BDD) is a psychiatric condition characterized by excessive preoccupation with perceived flaws in physical appearance, often encountered in dermatologic settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to validate the Arabic Body Dysmorphic Disorder Questionnaire (BDDQ), used in the dermatologic setting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using previous versions of BDDQ, we developed a scale that considers the dermatologic setting and conditions and translated it into Arabic. The new tool was assessed for its construct, structural, and criterion validity and reliability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The newly developed tool had an appropriate construct validity; it was unidimensional (57% variance explanation), with excellent internal consistency (Cronbach alpha = 0.889). The structural (significant inter-item and item-scale Spearman correlation coefficients) and criterion validity measures (AUC = 0.869) were also appropriate. Compared to a physician diagnosis of BDD, two cut-off values were defined for the scale: 11.5 for screening purposes (Se = 100%; Sp = 31%), and 18.5 for diagnostic purposes (Se = 83% and Sp = 83.5%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study developed and validated a quantitative scale in a dermatology setting, the Arabic BDDQ scale. Further studies are recommended to confirm the scale's efficiency for screening and diagnostic purposes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50310,"journal":{"name":"International Journal of Methods in Psychiatric Research","volume":"34 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mpr.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qian Xiao, Liying Shen, Fangling Li, Furong Jiang, Bei Xu
Background
Major depressive disorder (MDD) and borderline personality disorder (BPD) are psychiatric conditions with overlapping clinical features but distinct pathologies. This study aims to explore the microvascular changes in superficial retinal capillary plexus (SRCP) in patients between MDD and BPD using Optical Coherence Tomography (OCT) and Optical coherence tomography angiography (OCTA), as well as determine their clinical diagnostic value.
Methods
The study involved 35 MDD patients, 36 BPD patients, and 36 healthy controls (HCs). OCTA and OCT were used to assess macular vessel density (MVD) and peripapillary vessel density (PVD), retinal nerve fiber layer (RNFL), and central retinal thickness (CRT). The study also evaluated the correlation of these ocular parameters with clinical symptoms.
Results
Both MDD and BPD patients showed significant reductions in MVD, RNFL and CRT compared to HCs (all p < 0.05). BPD patients exhibited more pronounced decreases in the foveal area, RNFL and CRT than MDD patients (all p < 0.05). These ocular changes were associated with BPD symptom severity (all p < 0.05). The RNFL and CRT demonstrated potential as diagnostic markers for BPD (AUROCs of 0.625 and 0.695, p < 0.05).
Conclusions
OCT and OCTA might differentiate between MDD and BPD by identifying specific ocular changes, suggesting distinct neurobiological mechanisms for each disorder. These technologies hold promise for improving diagnostic accuracy.
{"title":"Exploration of the Value of Optical Coherence Tomography (OCT) and OCT Angiography in Differentiating Between Major Depressive Disorder and Borderline Personality Disorder","authors":"Qian Xiao, Liying Shen, Fangling Li, Furong Jiang, Bei Xu","doi":"10.1002/mpr.70043","DOIUrl":"10.1002/mpr.70043","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Major depressive disorder (MDD) and borderline personality disorder (BPD) are psychiatric conditions with overlapping clinical features but distinct pathologies. This study aims to explore the microvascular changes in superficial retinal capillary plexus (SRCP) in patients between MDD and BPD using Optical Coherence Tomography (OCT) and Optical coherence tomography angiography (OCTA), as well as determine their clinical diagnostic value.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study involved 35 MDD patients, 36 BPD patients, and 36 healthy controls (HCs). OCTA and OCT were used to assess macular vessel density (MVD) and peripapillary vessel density (PVD), retinal nerve fiber layer (RNFL), and central retinal thickness (CRT). The study also evaluated the correlation of these ocular parameters with clinical symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both MDD and BPD patients showed significant reductions in MVD, RNFL and CRT compared to HCs (all <i>p</i> < 0.05). BPD patients exhibited more pronounced decreases in the foveal area, RNFL and CRT than MDD patients (all <i>p</i> < 0.05). These ocular changes were associated with BPD symptom severity (all <i>p</i> < 0.05). The RNFL and CRT demonstrated potential as diagnostic markers for BPD (AUROCs of 0.625 and 0.695, <i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>OCT and OCTA might differentiate between MDD and BPD by identifying specific ocular changes, suggesting distinct neurobiological mechanisms for each disorder. These technologies hold promise for improving diagnostic accuracy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50310,"journal":{"name":"International Journal of Methods in Psychiatric Research","volume":"34 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12586372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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