Increasing muscular strength to improve cardiometabolic risk factors

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE Clinica e Investigacion en Arteriosclerosis Pub Date : 2023-05-01 DOI:10.1016/j.arteri.2022.12.002
Patricio Lopez-Jaramillo , Jose P. Lopez-Lopez , Maria Camila Tole , Daniel D. Cohen
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Abstract

Cardiovascular diseases (CVDs) remain the leading cause of worldwide death, accounting for significant morbidity, mortality, disability, and reduced quality of life. The global prevalence of cardiovascular (CV) risk factors, such as type 2 diabetes mellitus, hypertension, dyslipidemia, and obesity, has grown exponentially in the last decades, particularly in low-medium income countries, and it's projected to increase rapidly in the coming years as the population progressively ages, leading to increased cardiovascular disease (CVD) and associated mortality. In fact, data from the global burden of disease study shows that CV mortality, associated disability-adjusted life years (DALYs), and years of life lost (YLL) have increased steadily, nearly doubling from 1990 to 2019.

Recent evidence proves the existence of an inverse association between hand grip strength (HGS), as a proxy for global muscle strength, with all-cause mortality, CV mortality, and the development of several chronic diseases. These associations have been demonstrated recurringly across the entire lifespan, beginning in childhood, and carrying on throughout adult life. Mounting evidence strongly indicates that HGS is an early predictor of chronic disease in premorbid populations and a therapeutic target for CVD prevention. Recent clinical trials have consistently shown that resistance exercise, which increases strength and potentially muscle mass, significantly improves the control of known CVD risk factors, reduces the risk of all-cause death and cardiovascular mortality.

In this review, we explore the latest evidence regarding the association between low muscle strength and diverse metabolic alterations, along with the interventions that could improve cardiometabolic risk factors, while simultaneously increasing muscle fitness.

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增加肌肉力量以改善心脏代谢的危险因素
心血管疾病(CVD)仍然是全球死亡的主要原因,造成了严重的发病率、死亡率、残疾和生活质量下降。心血管(CV)危险因素的全球流行率,如2型糖尿病、高血压、血脂异常和肥胖,在过去几十年中呈指数级增长,特别是在中低收入国家,随着人口年龄的增长,预计在未来几年将迅速增加,导致心血管疾病(CVD)和相关死亡率增加。事实上,来自全球疾病负担研究的数据显示,CV死亡率、相关残疾调整生命年(DALYs)和生命损失年(YLL)稳步上升,从1990年到2019年几乎翻了一番。最近的证据证明,作为全球肌肉力量指标的握力(HGS)与全因死亡率、CV死亡率,以及几种慢性疾病的发展。这些关联在整个生命周期中反复出现,从童年开始,一直延续到成年。越来越多的证据有力地表明,HGS是病前人群中慢性病的早期预测因子,也是预防CVD的治疗靶点。最近的临床试验一致表明,阻力运动可以增加力量和潜在的肌肉质量,显著改善对已知心血管疾病危险因素的控制,降低全因死亡和心血管死亡率的风险。在这篇综述中,我们探讨了有关低肌肉力量与多种代谢变化之间关系的最新证据,以及可以改善心脏代谢风险因素的干预措施,同时提高肌肉素质。
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来源期刊
Clinica e Investigacion en Arteriosclerosis
Clinica e Investigacion en Arteriosclerosis PERIPHERAL VASCULAR DISEASE-
CiteScore
3.20
自引率
6.20%
发文量
44
审稿时长
40 days
期刊介绍: La publicación idónea para acceder tanto a los últimos originales de investigación como a formación médica continuada sobre la arteriosclerosis y su etiología, epidemiología, fisiopatología, diagnóstico y tratamiento. Además, es la publicación oficial de la Sociedad Española de Arteriosclerosis.
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