Lower omega-3 status associated with higher erythrocyte distribution width and neutrophil-lymphocyte ratio in UK Biobank cohort

Michael I. McBurney , Nathan L. Tintle , William S. Harris
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Abstract

High red blood distribution width (RDW) is associated with decreased red blood cell deformability, and high neutrophil-lymphocyte ratio (NLR) is a biomarker of systemic inflammation and innate-adaptive immune system imbalance. Both RDW and NLR are predictors of chronic disease risk and mortality. Omega-3 index (O3I) values have previously been shown to be inversely associated with RDW and NLR levels. Our objective was to determine if total plasma long chain omega-3 fatty acids (Omega3%) measured in the UK Biobank cohort were associated with RDW and NLR values. RDW- and NLR- relationships with Omega3% were characterized in 109,191 adults (58.4% female). RDW- and NLR-Omega3% relationships were inversely associated with Omega3% (both p < 0.0001). These cross-sectional associations confirm previous findings that increasing RDW and NLR values are associated with low O3I. The hypothesis that RDW and/or NLR values can be reduced in individuals with less-than optimal long chain omega 3 values need to be tested in randomized controlled intervention trials using EPA and/or DHA.

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在英国生物银行队列中,较低的omega-3状态与较高的红细胞分布宽度和中性粒细胞-淋巴细胞比率相关
高红细胞分布宽度(RDW)与红细胞变形能力降低有关,而高中性粒细胞淋巴细胞比率(NLR)是全身炎症和先天适应性免疫系统失衡的生物标志物。RDW和NLR都是慢性病风险和死亡率的预测因子。Omega-3指数(O3I)值先前已被证明与RDW和NLR水平呈负相关。我们的目的是确定在英国生物银行队列中测量的总血浆长链ω-3脂肪酸(ω3%)是否与RDW和NLR值相关。109191名成年人(58.4%为女性)具有与Omega3%的RDW和NLR关系。RDW-和NLR-Omega3%的关系与Omega3%呈负相关(均p<0.0001)。这些横截面关联证实了先前的研究结果,即RDW和NLR值的增加与低O3I有关。长链ω3值低于最佳值的个体的RDW和/或NLR值可能会降低,这一假设需要在使用EPA和/或DHA的随机对照干预试验中进行测试。
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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
自引率
0.00%
发文量
0
审稿时长
64 days
期刊最新文献
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