Dysregulated metabolism: A friend-to-foe skewer of macrophages.

IF 4.3 4区 医学 Q2 IMMUNOLOGY International Reviews of Immunology Pub Date : 2023-01-01 DOI:10.1080/08830185.2022.2095374
Keywan Mortezaee, Jamal Majidpoor
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引用次数: 10

Abstract

Metabolic reprogramming is a hallmark of solid cancers. Macrophages as major constituents of immune system take important roles in regulation of tumorigenesis. Pro-tumor M2 macrophages preferentially use oxidative phosphorylation (OXPHOS) to meet their metabolic demands, while anti-tumor M1 macrophages use glycolysis as their dominant metabolic source. Dysregulation in metabolic systems is a driving force of skewing macrophages from M1 toward M2 phenotypical state. Hyperactive M1 macrophages, for instance, release metabolic products that are contributed to M2 macrophage polarization. Thus, metabolic remodeling through reinstating normalization in metabolic systems can be an effective tool in cancer therapy. The key focus of this review is over metabolic systems in macrophages and factors influencing their metabolic acquisition and reprogramming in cancer, as well as discussing bout strategies to adjust macrophage metabolism and reeducation toward M1-like phenotype.

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代谢失调:巨噬细胞的友对敌串。
代谢重编程是实体癌症的一个标志。巨噬细胞作为免疫系统的主要组成部分,在肿瘤发生调控中起着重要作用。促肿瘤M2巨噬细胞优先使用氧化磷酸化(OXPHOS)来满足其代谢需求,而抗肿瘤M1巨噬细胞则以糖酵解为主要代谢来源。代谢系统失调是巨噬细胞从M1向M2表型状态倾斜的驱动力。例如,过度活跃的M1巨噬细胞释放代谢产物,促进M2巨噬细胞极化。因此,通过恢复代谢系统的正常化,代谢重塑可以成为癌症治疗的有效工具。本文综述了巨噬细胞的代谢系统及其在癌症中代谢获取和重编程的影响因素,并讨论了巨噬细胞代谢和向m1样表型的再教育的调整策略。
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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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