Cardiotoxicity of Anti-Cancer Radiation Therapy: a Focus on Heart Failure.

IF 3.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Current Heart Failure Reports Pub Date : 2023-02-01 DOI:10.1007/s11897-023-00587-0
Alex Ritter, Cooper Quartermaine, Jovan Pierre-Charles, Suryakumar Balasubramanian, Pejman Raeisi-Giglou, Daniel Addison, Eric Miller
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Abstract

Purpose of review: As the percentage of patients achieving long-term survival following treatment of their cancer grows, it is increasingly important to understand the long-term toxicities of cancer-directed treatment. In this review, we highlight the recent findings regarding radiation-induced cardiotoxicity across multiple disease sites, with a particular focus on heart failure.

Recent findings: Despite its relative lack of study historically, radiation-induced heart failure has now recently been implicated in several studies of breast cancer, lung cancer, esophageal cancer, and lymphoma as a non-trivial potential consequence of thoracic radiotherapy. Data regarding specific cardiac dosimetric endpoints relevant to cardiotoxicity continue to accumulate. Radiation-induced heart failure is a rare but significant toxicity of thoracic radiotherapy, that is likely underreported. Important areas for future focus include understanding the interplay between thoracic radiotherapy and concurrent cardiotoxic systemic therapy as well as development of potential mitigation strategies and novel therapeutics.

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抗癌放射治疗的心脏毒性:对心力衰竭的关注。
综述目的:随着癌症治疗后实现长期生存的患者比例的增加,了解癌症定向治疗的长期毒性变得越来越重要。在这篇综述中,我们强调了最近关于辐射引起的心脏毒性在多个疾病部位的发现,特别关注心力衰竭。最近发现:尽管历史上相对缺乏研究,但辐射诱发的心力衰竭最近在乳腺癌、肺癌、食管癌和淋巴瘤的几项研究中被认为是胸部放疗的一个重要潜在后果。与心脏毒性相关的特定心脏剂量终点的数据继续积累。辐射引起的心力衰竭是一种罕见但显著的胸部放疗毒性,这可能被低估了。未来重点关注的重要领域包括了解胸部放射治疗与并发心脏毒性全身治疗之间的相互作用,以及开发潜在的缓解策略和新疗法。
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来源期刊
Current Heart Failure Reports
Current Heart Failure Reports Medicine-Emergency Medicine
CiteScore
5.30
自引率
0.00%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
期刊最新文献
Cardiogenic Shock: Focus on Non-Cardiac Biomarkers. Biomarkers of Hemodynamic Congestion in Heart Failure. Heart Failure in Rheumatoid Arthritis: Clinical Implications. Screening for Heart Failure: Biomarkers to Detect Heightened Risk in the General Population. Troponin Elevation in Asymptomatic Cancer Patients: Unveiling Connections and Clinical Implications.
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