Association between maternal obesity, essential fatty acids and biomarkers of fetal liver function

IF 3 Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2023-03-01 DOI:10.1016/j.plefa.2023.102541

Macarena Ortiz , Francisca Sánchez , Daniela Álvarez , Cristian Flores , Francisca Salas-Pérez , Rodrigo Valenzuela , Claudette Cantin , Andrea Leiva , Nicolás Crisosto , Manuel Maliqueo

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Abstract

Maternal obesity and the imbalance in linoleic acid (C18:2 n-6, LA) and alpha-linolenic acid (C18:3 n-3, ALA) levels are related with hepatic disturbances in the offspring. However, whether these alterations are present during fetal life is not well understood. Obese and normal weight pregnant women were recruited to determine fatty acids (FAs) consumption, FAs profile (in maternal erythrocytes, placenta and neonatal very low-density lipoproteins VLDL) and biomarkers of fetal liver function, such as gamma-glutamyl transferase (GGT), alpha-fetoprotein (AFP) and albumin, in umbilical cord blood. Stearic acid (C18:0, ST) was lower, and total n-3 FAs tended to be lower in umbilical cord VLDLs of obese women compared to controls. Independently of maternal obesity, GGT levels in umbilical cord blood was positively correlated with the LA content and negatively correlated with the ALA content in maternal erythrocytes. We conclude that maternal obesity and its imbalance of LA and ALA are associated with changes in biomarkers of fetal liver function.

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母体肥胖、必需脂肪酸和胎儿肝功能生物标志物之间的关系

母亲肥胖和亚油酸(C18:2 n-6, LA)和α -亚麻酸(C18:3 n-3, ALA)水平失衡与后代肝脏紊乱有关。然而，这些改变是否存在于胎儿期尚不清楚。研究人员招募了肥胖和正常体重的孕妇，以测定其脂肪酸(FAs)消耗量、FAs谱(在母体红细胞、胎盘和新生儿极低密度脂蛋白VLDL中)和胎儿肝功能的生物标志物，如脐带血中的γ -谷氨酰转移酶(GGT)、甲胎蛋白(AFP)和白蛋白。硬脂酸(C18:0, ST)较低，与对照组相比，肥胖妇女脐带vldl的总n-3 FAs倾向于较低。与母体肥胖无关，脐带血GGT水平与LA含量呈正相关，与母体红细胞ALA含量负相关。我们得出结论，产妇肥胖及其LA和ALA失衡与胎儿肝功能生物标志物的变化有关。

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