You are fired! Exclusion words induce corticospinal modulations associated with vicarious pain.

IF 3.9 2区 医学 Q2 NEUROSCIENCES Social cognitive and affective neuroscience Pub Date : 2023-06-13 DOI:10.1093/scan/nsad033
Francesca Vitale, Mabel Urrutia, Alessio Avenanti, Manuel de Vega
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引用次数: 1

Abstract

Self- and vicarious experience of physical pain induces inhibition of the motor cortex (M1). Experience of social rejections recruits the same neural network as physical pain; however, whether social pain modulates M1 corticospinal excitability remains unclear. This study examines for the first time whether social exclusion words, rather than simulated social exclusion tasks, modulate embodied sensorimotor networks during the vicarious experience of others' pain. Participants observed visual sequences of painful and functional events ending with a superimposed word with social exclusion, social inclusion or non-social meaning. Motor-evoked potentials (MEPs) to single-pulse transcranial magnetic stimulation of the left M1 were recorded at 400 or 550 ms from word onset. MEPs tended to inhibit during the observation of pain, relative to functional events. Moreover, MEPs recorded at 400 ms from word onset, during pain movies, decreased following the presentation of exclusion, relative to inclusion/neutral words. The magnitude of these two modulations marginally correlated with participants' interindividual differences in personal distress and self-esteem. These findings provide evidence of vicarious responses to others' pain in the M1 corticospinal system and enhancement of such vicarious response in the earlier phases of semantic processing of exclusion words-supporting activation of social pain-embodied representations.

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你被解雇了!排除词诱导与替代疼痛相关的皮质脊髓调节。
身体疼痛的自我和替代体验诱导运动皮质(M1)的抑制。社会排斥的经历和身体疼痛一样,会激发神经网络;然而,社交疼痛是否调节M1皮质脊髓兴奋性仍不清楚。本研究首次考察了社会排斥词,而不是模拟的社会排斥任务,是否在他人痛苦的替代体验中调节具身感觉运动网络。参与者观察了一系列痛苦和功能性事件的视觉序列,这些事件以一个带有社会排斥、社会包容或非社会含义的叠加词结尾。在单词开始后400或550 ms记录左M1单脉冲经颅磁刺激的运动诱发电位(MEPs)。在观察疼痛时,相对于功能事件,MEPs倾向于抑制。此外,在疼痛电影中,在单词开始后400 ms记录的mep在出现排除词后相对于包含词/中性词下降。这两种调节的幅度与参与者在个人痛苦和自尊方面的个体间差异略有相关。这些发现为M1皮质脊髓系统对他人疼痛的替代反应提供了证据,并在排除词语义加工的早期阶段增强了这种替代反应,支持了社会疼痛具体化表征的激活。
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来源期刊
CiteScore
6.80
自引率
4.80%
发文量
62
审稿时长
4-8 weeks
期刊介绍: SCAN will consider research that uses neuroimaging (fMRI, MRI, PET, EEG, MEG), neuropsychological patient studies, animal lesion studies, single-cell recording, pharmacological perturbation, and transcranial magnetic stimulation. SCAN will also consider submissions that examine the mediational role of neural processes in linking social phenomena to physiological, neuroendocrine, immunological, developmental, and genetic processes. Additionally, SCAN will publish papers that address issues of mental and physical health as they relate to social and affective processes (e.g., autism, anxiety disorders, depression, stress, effects of child rearing) as long as cognitive neuroscience methods are used.
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