Cristina Vidal, Ignacio Robles, Noelia Escamilla, Diego Losada, Cristina Serrano, Carolina Miranda, Ana Isabel Pastor, Ester Carreño
{"title":"Hypopyon Uveitis as a Manifestation of Primary Choroidal Lymphoma.","authors":"Cristina Vidal, Ignacio Robles, Noelia Escamilla, Diego Losada, Cristina Serrano, Carolina Miranda, Ana Isabel Pastor, Ester Carreño","doi":"10.1080/09273948.2023.2220786","DOIUrl":null,"url":null,"abstract":"<p><p>A 78-year-old female was referred to our hospital due to a decrease of visual acuity in her left eye. On examination, presence of left choroidal folds and subretinal fluid was disclosed. After being misdiagnosed as neovascular age-related macular degeneration treatment with intravitreal injections of Aflibercept was started. Despite improvement of fluid, persistence of choroidal folds encouraged a magnetic resonance imaging revealing a left retrobulbar nodular lesion. Furthermore, development of hypopyon during follow-up allowed a flow cytometry analysis of an aqueous humour sample that confirmed infiltration by a non-Hodgkin mature B-cell lymphoproliferative process. Finally, treatment with Rituximab and intravenous corticosteroids achieved complete resolution. Primary choroidal lymphoma may occur with an atypical presentation, including hypopyon uveitis. Thus, familiarity with its clinical features is fundamental for an early recognition and correct management.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ocular Immunology and Inflammation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09273948.2023.2220786","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/6/21 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A 78-year-old female was referred to our hospital due to a decrease of visual acuity in her left eye. On examination, presence of left choroidal folds and subretinal fluid was disclosed. After being misdiagnosed as neovascular age-related macular degeneration treatment with intravitreal injections of Aflibercept was started. Despite improvement of fluid, persistence of choroidal folds encouraged a magnetic resonance imaging revealing a left retrobulbar nodular lesion. Furthermore, development of hypopyon during follow-up allowed a flow cytometry analysis of an aqueous humour sample that confirmed infiltration by a non-Hodgkin mature B-cell lymphoproliferative process. Finally, treatment with Rituximab and intravenous corticosteroids achieved complete resolution. Primary choroidal lymphoma may occur with an atypical presentation, including hypopyon uveitis. Thus, familiarity with its clinical features is fundamental for an early recognition and correct management.
一位 78 岁的女性因左眼视力下降而被转诊至我院。经检查，发现左眼脉络膜皱褶和视网膜下积液。在被误诊为新生血管性年龄相关性黄斑变性后，她开始接受阿弗利百普（Aflibercept）玻璃体内注射治疗。尽管积液有所改善，但脉络膜褶皱的持续存在促使磁共振成像检查发现了左侧球后结节性病变。此外，在随访过程中，患者出现了眼睑下垂，因此对其眼屎样本进行了流式细胞术分析，结果证实了非霍奇金成熟 B 细胞淋巴增生过程的浸润。最后，使用利妥昔单抗和静脉注射皮质类固醇治疗后，病情得到了完全缓解。原发性脉络膜淋巴瘤可能表现不典型，包括葡萄膜下炎。因此，熟悉其临床特征是早期识别和正确治疗的基础。
期刊介绍：
Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
