Hematological and biochemical profiles in children with cerebral palsy: A cross-sectional study.

IF 0.8 Q4 PEDIATRICS Journal of pediatric rehabilitation medicine Pub Date : 2023-01-01 DOI:10.3233/PRM-201514
Rohit Khandelwal, Vivek Vankalapati Manjunath, Leeni Mehta, Shivalingappa Bussenahalli Mangajjera
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Abstract

Purpose: Cerebral palsy is a common pediatric neurological problem that has multiple comorbidities, including nutritional issues. Hematological and biochemical parameters significantly affect the health status of patients with cerebral palsy, and till now very few studies have analyzed these parameters. This study aimed to describe the hematological and biochemical parameters of children diagnosed with cerebral palsy.

Methods: This four-year observational study included children with cerebral palsy who were admitted to the Department of Pediatrics of a medical college teaching hospital.Hemoglobin, platelet count, white blood count (WBC), red blood cells (RBCs), packed cell volume, RBC indices, and biochemical parameters (urea, creatinine, total bilirubin, total protein, albumin, globulin, aspartate transaminase, alanine transaminase, electrolytes, calcium and alkaline phosphatase) were noted and values (mean, standard deviation, and interquartile range) presented. Age and gender-based analyses were performed.

Results: The average hemoglobin level was 11.48 mg/dl, platelet count was 301.24×109/L, and WBC count was 11.13 109/L. Anemia was observed more commonly in males younger than nine years of age. Of 282 patients, 14 (4.96%) had a platelet count of less than 150×109/L. Abnormal alkaline phosphatase levels were observed more commonly in patients who were younger than nine years of age and in females more than males, and the difference was statistically significant. Protein levels and calcium levels were similar between both age groups.

Conclusion: Anemia was more common in younger patients and males with cerebral palsy. Abnormal bone turnover markers (alkaline phosphatase) were more common in young patients and females with cerebral palsy. Understanding the differential effect of age and gender on various investigational parameters will help improve care of children with cerebral palsy by initiating appropriate and timely clinical interventions, thereby providing a better quality of life.

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脑瘫儿童血液学和生化特征:一项横断面研究。
目的:脑瘫是一种常见的小儿神经系统疾病,有多种合并症,包括营养问题。血液学和生化指标对脑瘫患者的健康状况有显著影响,迄今为止对这些指标进行分析的研究很少。本研究旨在描述诊断为脑瘫儿童的血液学和生化参数。方法:对某医学院附属医院儿科收治的脑瘫患儿进行为期四年的观察性研究。记录血红蛋白、血小板计数、白细胞计数(WBC)、红细胞(RBC)、堆积细胞体积、红细胞指数、生化参数(尿素、肌酐、总胆红素、总蛋白、白蛋白、球蛋白、天冬氨酸转氨酶、丙氨酸转氨酶、电解质、钙和碱性磷酸酶)并给出数值(平均值、标准差和四分位数范围)。进行了年龄和性别分析。结果:平均血红蛋白水平11.48 mg/dl,血小板计数301.24×109/L,白细胞计数11.13 109/L。贫血在9岁以下的男性中更为常见。282例患者中,14例(4.96%)血小板计数低于150×109/L。碱性磷酸酶异常多见于9岁以下患者,且女性多于男性,差异有统计学意义。两个年龄组的蛋白质水平和钙水平相似。结论:贫血多见于年轻患者和男性脑瘫患者。骨转换标志物(碱性磷酸酶)异常在年轻患者和女性脑瘫患者中更为常见。了解年龄和性别对各种研究参数的差异影响将有助于通过启动适当和及时的临床干预来改善脑瘫儿童的护理,从而提供更好的生活质量。
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来源期刊
CiteScore
2.30
自引率
5.30%
发文量
139
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