Periodontal Disease Pathogens, Pathogenesis, and Therapeutics: The CRISPR-Cas Effect.

IF 3.7 4区 生物学 Q2 GENETICS & HEREDITY CRISPR Journal Pub Date : 2023-04-01 DOI:10.1089/crispr.2022.0094
Madhurya N Kedlaya, Lakshmi Puzhankara, Rohit Prasad, Akshatha Raj
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引用次数: 1

Abstract

Periodontal disease (PD) is an immune-inflammatory disease affecting the supporting structures of the teeth, which results in progressive destruction of the hard and soft tissues surrounding teeth, ultimately resulting in tooth loss. The primary etiological factor for this disease is the presence of pathogenic microorganisms. Pathogenic bacteria face antagonistic conditions and foreign DNA components during the infection stage and depend on defense mechanisms such as clustered regularly interspaced short palindromic repeats (CRISPR)-Cas to counter them. Virulence genes regulated by the CRISPR-Cas system are often expressed by bacteria as part of the stress response to the presence of stress conditions and foreign elements. There is ever-growing evidence regarding the role of CRISPR-Cas in virulence of periodontal pathogens. The same CRISPR-Cas system may also be targeted to reduce bacterial virulence and it may also be utilized to develop diagnostic and therapeutic strategies for prevention and control of PD progression. This review article describes the CRISPR-Cas systems in the periodontal dysbiotic microbial communities, their role in the virulence of periodontal pathogens, and their potential role in understanding the pathogenesis of periodontitis and treatment of PD.

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牙周病病原体、发病机制和治疗:CRISPR-Cas效应。
牙周病(Periodontal disease, PD)是一种影响牙齿支撑结构的免疫炎症性疾病,其结果是牙齿周围的硬组织和软组织逐渐被破坏,最终导致牙齿脱落。本病的主要病因是病原微生物的存在。病原菌在感染阶段面临拮抗条件和外源DNA成分,依赖于聚集规律间隔短回文重复序列(CRISPR -Cas)等防御机制来对抗它们。由CRISPR-Cas系统调控的毒力基因通常作为细菌对应激条件和外来因素的应激反应的一部分而表达。有越来越多的证据表明CRISPR-Cas在牙周病原体的毒力中的作用。同样的CRISPR-Cas系统也可以用于降低细菌毒力,也可以用于制定预防和控制PD进展的诊断和治疗策略。这篇综述文章介绍了CRISPR-Cas系统在牙周微生物群落中的作用,它们在牙周病原体的毒力中的作用,以及它们在了解牙周炎的发病机制和PD治疗中的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CRISPR Journal
CRISPR Journal Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
6.30
自引率
2.70%
发文量
76
期刊介绍: In recognition of this extraordinary scientific and technological era, Mary Ann Liebert, Inc., publishers recently announced the creation of The CRISPR Journal -- an international, multidisciplinary peer-reviewed journal publishing outstanding research on the myriad applications and underlying technology of CRISPR. Debuting in 2018, The CRISPR Journal will be published online and in print with flexible open access options, providing a high-profile venue for groundbreaking research, as well as lively and provocative commentary, analysis, and debate. The CRISPR Journal adds an exciting and dynamic component to the Mary Ann Liebert, Inc. portfolio, which includes GEN (Genetic Engineering & Biotechnology News) and more than 80 leading peer-reviewed journals.
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