Role of Vagus Nerve Stimulation in the Treatment of Chronic Pain.

IF 2.2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Neuroimmunomodulation Pub Date : 2023-01-01 Epub Date: 2023-06-27 DOI:10.1159/000531626
Peiqi Shao, Huili Li, Jia Jiang, Yun Guan, Xueming Chen, Yun Wang
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Abstract

Vagus nerve stimulation (VNS) can modulate vagal activity and neuro-immune communication. Human and animal studies have provided growing evidence that VNS can produce analgesic effects in addition to alleviating refractory epilepsy and depression. The vagus nerve (VN) projects to many brain regions related to pain processing, which can be affected by VNS. In addition to neural regulation, the anti-inflammatory property of VNS may also contribute to its pain-inhibitory effects. To date, both invasive and noninvasive VNS devices have been developed, with noninvasive devices including transcutaneous stimulation of auricular VN or carotid VN that are undergoing many clinical trials for chronic pain treatment. This review aimed to provide an update on both preclinical and clinical studies of VNS in the management for chronic pain, including fibromyalgia, abdominal pain, and headaches. We further discuss potential underlying mechanisms for VNS to inhibit chronic pain.

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迷走神经刺激在治疗慢性疼痛中的作用。
迷走神经刺激(VNS)可以调节迷走神经活动和神经免疫通讯。人类和动物研究提供了越来越多的证据,证明VNS除了可以缓解难治性癫痫和抑郁症外,还可以产生镇痛作用。迷走神经(VN)投射到许多与疼痛处理相关的大脑区域,这些区域可能受到VNS的影响。除了神经调节外,VNS的抗炎特性也可能有助于其疼痛抑制作用。到目前为止,已经开发出有创和无创VNS设备,其中包括经皮刺激耳廓VN或颈动脉VN的无创设备正在进行许多慢性疼痛治疗的临床试验。这篇综述旨在提供VNS治疗慢性疼痛(包括纤维肌痛、腹痛和头痛等)的临床前和临床研究的最新进展。我们进一步讨论了VNS抑制慢性疼痛的潜在潜在潜在机制。
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来源期刊
Neuroimmunomodulation
Neuroimmunomodulation 医学-免疫学
CiteScore
3.60
自引率
4.20%
发文量
35
审稿时长
>12 weeks
期刊介绍: The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.
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