The dynamics along the biointerface between the epithelial and cancer mesenchymal cells: Modeling consideration

IF 6.2 2区 生物学 Q1 CELL BIOLOGY Seminars in cell & developmental biology Pub Date : 2023-09-30 DOI:10.1016/j.semcdb.2022.12.010
Ivana Pajic-Lijakovic , Raluca Eftimie , Milan Milivojevic , Stéphane P.A. Bordas
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引用次数: 3

Abstract

Epithelial cancer is the one of most lethal cancer type worldwide. Targeting the early stage of disease would allow dramatic improvements in the survival of cancer patients. The early stage of the disease is related to cancer cell spreading across surrounding healthy epithelium. Consequently, deeper insight into cell dynamics along the biointerface between epithelial and cancer (mesenchymal) cells is necessary in order to control the disease as soon as possible. Cell dynamics along this epithelial-cancer biointerface is the result of the interplay between various biological and physical mechanisms. Despite extensive research devoted to study cancer cell spreading across the epithelium, we still do not understand the physical mechanisms which influences the dynamics along the biointerface. These physical mechanisms are related to the interplay between physical parameters such as: (1) interfacial tension between cancer and epithelial subpopulations, (2) established interfacial tension gradients, (3) the bending rigidity of the biointerface and its impact on the interfacial tension, (4) surface tension of the subpopulations, (5) viscoelasticity caused by collective cell migration, and (6) cell residual stress accumulation. The main goal of this study is to review some of these physical parameters in the context of the epithelial/cancer biointerface elaborated on the model system such as the biointerface between breast epithelial MCF-10A cells and cancer MDA-MB-231 cells and then to incorporate these parameters into a new biophysical model that could describe the dynamics of the biointerface. We conclude by discussing three biophysical scenarios for cell dynamics along the biointerface, which can occur depending on the magnitude of the generated shear stress: a smooth biointerface, a slightly-perturbed biointerface and an intensively-perturbed biointerface in the context of the Kelvin-Helmholtz instability. These scenarios are related to the probability of cancer invasion.

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沿上皮细胞和癌间充质细胞之间的生物界面动力学:建模考虑
癌症是世界上最致命的癌症类型之一。以疾病的早期阶段为目标,将大大提高癌症患者的生存率。疾病的早期阶段与癌症细胞在周围健康上皮细胞中扩散有关。因此,为了尽快控制疾病,有必要深入了解上皮细胞和癌症(间充质)细胞之间生物界面上的细胞动力学。沿着上皮-癌生物界面的细胞动力学是各种生物学和物理机制相互作用的结果。尽管广泛的研究致力于研究癌症细胞在上皮上的扩散,但我们仍然不了解影响生物界面动力学的物理机制。这些物理机制与物理参数之间的相互作用有关,例如:(1)癌症和上皮亚群之间的界面张力,(2)建立的界面张力梯度,(3)生物界面的弯曲刚度及其对界面张力的影响,(4)亚群的表面张力,(5)由细胞集体迁移引起的粘弹性,(6)细胞残余应力积累。本研究的主要目标是在模型系统中阐述的上皮/癌症生物界面(如乳腺上皮MCF-10A细胞和癌症MDA-MB-231细胞之间的生物界面)的背景下回顾这些物理参数中的一些,然后将这些参数纳入一个新的生物物理模型中,该模型可以描述生物界面的动力学。最后,我们讨论了生物界面上细胞动力学的三种生物物理场景,这三种场景可能根据产生的剪切应力的大小而发生:在开尔文-亥姆霍兹不稳定性的背景下,光滑的生物界面、轻微扰动的生物界面和强烈扰动的生物接口。这些情况与癌症侵袭的概率有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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Diverse genetic conflicts mediated by molecular mimicry and computational approaches to detect them Outside Front Cover Editorial Board/Publication Information From the cauldron of conflict: Endogenous gene regulation by piRNA and other modes of adaptation enabled by selfish transposable elements Outside Front Cover
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