Preclinical Disease or Risk Factor? Alzheimer's Disease as a Case Study of Changing Conceptualizations of Disease.

IF 1.3 3区 哲学 Q3 ETHICS Journal of Medicine and Philosophy Pub Date : 2023-06-20 DOI:10.1093/jmp/jhad009
Maartje H N Schermer
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引用次数: 1

Abstract

Alzheimer's Disease (AD) provides an excellent case study to investigate emerging conceptions of health, disease, pre-disease, and risk. Two scientific working groups have recently reconceptualized AD and created a new category of asymptomatic biomarker positive persons, who are either said to have preclinical AD, or to be at risk for AD. This article examines how prominent theories of health and disease would classify this condition: healthy or diseased? Next, the notion of being "at risk"-a state somewhere in-between health and disease-is considered from various angles. It is concluded that medical-scientific developments urge us to let go of dichotomous ways of understanding disease, that the notion of "risk," conceptualized as an increased chance of getting a symptomatic disease, might be a useful addition to our conceptual framework, and that we should pay more attention to the practical usefulness and implications of the ways in which we draw lines and define concepts.

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临床前疾病还是危险因素?阿尔茨海默病:疾病概念变化的个案研究。
阿尔茨海默病(AD)提供了一个很好的案例研究,以调查健康,疾病,疾病前期和风险的新兴概念。两个科学工作组最近重新定义了阿尔茨海默病,并创建了一个新的无症状生物标志物阳性人群类别,这些人要么被认为患有临床前阿尔茨海默病,要么有患阿尔茨海默病的风险。这篇文章探讨了著名的健康和疾病理论是如何对这种状况进行分类的:健康还是患病?其次,“处于危险”的概念——介于健康和疾病之间的某种状态——从不同的角度被考虑。结论是,医学科学的发展促使我们放弃理解疾病的两分法,“风险”的概念被概念化为获得症状性疾病的机会增加,这可能是对我们概念框架的有益补充,我们应该更多地关注我们划线和定义概念的方法的实际用途和含义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.90
自引率
6.20%
发文量
30
期刊介绍: This bimonthly publication explores the shared themes and concerns of philosophy and the medical sciences. Central issues in medical research and practice have important philosophical dimensions, for, in treating disease and promoting health, medicine involves presuppositions about human goals and values. Conversely, the concerns of philosophy often significantly relate to those of medicine, as philosophers seek to understand the nature of medical knowledge and the human condition in the modern world. In addition, recent developments in medical technology and treatment create moral problems that raise important philosophical questions. The Journal of Medicine and Philosophy aims to provide an ongoing forum for the discussion of such themes and issues.
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