MRI characterization of in vitro clots at 3T and 7T: A technical note

IF 3 3区 医学 Q2 CLINICAL NEUROLOGY Journal of Neuroradiology Pub Date : 2024-02-01 DOI:10.1016/j.neurad.2023.06.003
Daniela Dumitriu LaGrange , Lijing Xin , François Lazeyras , Karen M. Doyle , Isabel Wanke , Karl-Olof Lövblad
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Abstract

In acute ischemic stroke, the composition of the occlusive clot can be associated with the underlying pathophysiology and the response to treatment. For these reasons, it is important to characterize the clot composition from clinical scans. We examine the ability of 3T and 7T MRI to distinguish the composition of in vitro clots, using quantitative T1 and T2*, alternatively R2*, mapping. When comparing the two field strengths, we found a tradeoff between sensitivity for clot composition and confidence in the clot depiction associated with spatial resolution. The loss of sensitivity at 7T can be mitigated by combining the T1 and T2* signals.

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3T 和 7T 下体外血凝块的磁共振成像特征:技术说明
在急性缺血性脑卒中中,闭塞性血栓的组成可能与潜在的病理生理学和治疗反应有关。因此,从临床扫描中确定血凝块的组成特征非常重要。我们利用定量 T1 和 T2*(或 R2*)映射检查了 3T 和 7T MRI 区分体外血凝块成分的能力。在比较两种磁场强度时,我们发现血凝块成分的灵敏度与空间分辨率相关的血凝块描绘可信度之间存在权衡。将 T1 和 T2* 信号结合在一起可减轻 7T 下灵敏度的损失。
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来源期刊
Journal of Neuroradiology
Journal of Neuroradiology 医学-核医学
CiteScore
6.10
自引率
5.70%
发文量
142
审稿时长
6-12 weeks
期刊介绍: The Journal of Neuroradiology is a peer-reviewed journal, publishing worldwide clinical and basic research in the field of diagnostic and Interventional neuroradiology, translational and molecular neuroimaging, and artificial intelligence in neuroradiology. The Journal of Neuroradiology considers for publication articles, reviews, technical notes and letters to the editors (correspondence section), provided that the methodology and scientific content are of high quality, and that the results will have substantial clinical impact and/or physiological importance.
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