Regulatory T lymphocytes as a therapy for ischemic stroke.

IF 7.9 2区 医学 Q1 IMMUNOLOGY Seminars in Immunopathology Pub Date : 2023-05-01 Epub Date: 2022-12-05 DOI:10.1007/s00281-022-00975-z
Miao Wang, Angus W Thomson, Fang Yu, Rimi Hazra, Aditi Junagade, Xiaoming Hu
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Abstract

Unrestrained excessive inflammatory responses exacerbate ischemic brain injury and impede post-stroke brain recovery. CD4+CD25+Foxp3+ regulatory T (Treg) cells play important immunosuppressive roles to curtail inflammatory responses and regain immune homeostasis after stroke. Accumulating evidence confirms that Treg cells are neuroprotective at the acute stage after stroke and promote brain repair at the chronic phases. The beneficial effects of Treg cells are mediated by diverse mechanisms involving cell-cell interactions and soluble factor release. Multiple types of cells, including both immune cells and non-immune CNS cells, have been identified to be cellular targets of Treg cells. In this review, we summarize recent findings regarding the function of Treg cells in ischemic stroke and the underlying cellular and molecular mechanisms. The protective and reparative properties of Treg cells endorse them as good candidates for immune therapy. Strategies that boost the numbers and functions of Treg cells have been actively developing in the fields of transplantation and autoimmune diseases. We discuss the approaches for Treg cell expansion that have been tested in stroke models. The application of these approaches to stroke patients may bring new hope for stroke treatments.

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调节性 T 淋巴细胞作为缺血性中风的一种疗法。
无节制的过度炎症反应会加重缺血性脑损伤,阻碍中风后大脑的恢复。CD4+CD25+Foxp3+ 调节性 T(Treg)细胞在中风后发挥重要的免疫抑制作用,抑制炎症反应,恢复免疫平衡。越来越多的证据证实,Treg 细胞在中风后的急性期具有神经保护作用,并在慢性期促进大脑修复。Treg 细胞的有益作用由多种机制介导,涉及细胞-细胞相互作用和可溶性因子释放。包括免疫细胞和非免疫中枢神经系统细胞在内的多种类型的细胞已被确定为 Treg 细胞的细胞靶标。在本综述中,我们总结了有关 Treg 细胞在缺血性中风中的功能及其潜在的细胞和分子机制的最新发现。Treg 细胞的保护和修复特性使其成为免疫疗法的理想候选者。移植和自身免疫性疾病领域一直在积极开发提高 Treg 细胞数量和功能的策略。我们讨论了在中风模型中测试的 Treg 细胞扩增方法。将这些方法应用于中风患者可能会为中风治疗带来新的希望。
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来源期刊
Seminars in Immunopathology
Seminars in Immunopathology 医学-病理学
CiteScore
19.80
自引率
2.20%
发文量
69
审稿时长
12 months
期刊介绍: The aim of Seminars in Immunopathology is to bring clinicians and pathologists up-to-date on developments in the field of immunopathology.For this purpose topical issues will be organized usually with the help of a guest editor.Recent developments are summarized in review articles by authors who have personally contributed to the specific topic.
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