Unification of medicines and excipients: The roles of natural excipients for promoting drug delivery.

IF 5 2区医学 Q1 PHARMACOLOGY & PHARMACY Expert Opinion on Drug Delivery Pub Date : 2023-05-01 Epub Date: 2023-05-16 DOI:10.1080/17425247.2023.2210835

Minfang Feng, Xingxing Dai, Cuiting Yang, Yingying Zhang, Yuting Tian, Qingsong Qu, Mengke Sheng, Zhixun Li, Xinhui Peng, Shuai Cen, Xinyuan Shi

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Abstract

Introduction: Drug delivery systems (DDSs) formed by natural active compounds be instrumental in developing new green excipients and novel DDS from natural active compounds (NACs). 'Unification of medicines and excipients'(UME), the special inherent nature of the natural active compounds, provides the inspiration and conduction to achieve this goal.

Areas covered: This review summarizes the typical types of NACs from herbal medicine, such as saponins, flavonoids, polysaccharides, etc. that act as excipients and their main application in DDS. The comparison of the drug delivery systems formed by NACs and common materials and the primary formation mechanisms of these NACs are also introduced to provide a deepened understanding of their performance in DDS.

Expert opinion: Many natural bioactive compounds, such as saponins, polysaccharides, etc. have been used in DDS. Diversity of structure and pharmacological effects of NACs turn out the unique advantages in improving the performance of DDSs like targeting ability, adhesion, encapsulation efficiency(EE), etc. and enhancing the bioavailability of loaded drugs.

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药物与辅料的统一：天然辅料在促进药物输送方面的作用。

导言：由天然活性化合物形成的给药系统（DDSs）有助于开发新的绿色辅料和新型天然活性化合物给药系统（NACs）。药与辅料的统一"（UME）--天然活性化合物与生俱来的特殊性质--为实现这一目标提供了灵感和传导：本综述总结了中药中典型的 NACs 类型，如作为辅料的皂苷、黄酮类、多糖等，以及它们在 DDS 中的主要应用。此外，还介绍了 NAC 与常见材料形成的给药系统的比较，以及这些 NAC 的主要形成机制，以加深对其在 DDS 中性能的理解：许多天然生物活性化合物，如皂甙、多糖等，已被用于 DDS。专家观点：许多天然生物活性化合物（如皂苷、多糖等）已被用于 DDS，而 NAC 结构和药理作用的多样性使其在改善 DDS 的性能（如靶向能力、粘附性、包封效率（EE）等）以及提高负载药物的生物利用度方面具有独特的优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Opinion on Drug Delivery 医学-药学

CiteScore

11.10

自引率

3.00%

发文量

104

审稿时长

3 months

期刊介绍： Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.