The Evaluation of Sentinel Lymph Node Biopsy Using Radiocolloid in First Stage Endometrial Cancer.

IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Molecular Imaging and Radionuclide Therapy Pub Date : 2023-06-20 DOI:10.4274/mirt.galenos.2022.36097

Anamarija Jankulovska, Sinisha Stojanoski, Sasho Stojcevski, Igor Aluloski, Rubens Jovanovic, Slavica Kostadinova Kunovska, Mile Tanturovski, Nevena Manevska, Gordana Petrusevska, Daniela Miladinova

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Abstract

Objectives: Detection of a sentinel lymph node (SLN) in patients with endometrial cancer (EC) reduces the rate of unnecessary systemic lymph dissection. The aim of this study was to assess the SLN detection rate, accuracy of the method using Tc-99m-SENTI-SCINT and the rate of metastatic nodal involvement in patients with preoperative first stage EC.

Methods: A prospective study of SLN biopsy of 41 patients with stage I EC was conducted after cervical application of 4mCi Tc-99m-SENTI-SCINT. Planar lymphoscintigraphy and single-photon emission computed tomography/computed tomography (SPECT/CT) of the pelvis were performed, followed by site-specific lymphadenectomy in intermediate-risk patients if no SLN was detected per hemipelvis and pelvic lymphadenectomy in all high-risk patients.

Results: Pre-operative detection rate of planar lymphoscintigraphy was 80.49 [95% confidence interval (CI): 68.36-92.62] and of SPECT/CT 95.12 (95% CI: 88.52-101.7). The total intraoperative SLN detection rate was 95.12 (95% CI: 88.52-101.7) per patient and 26.83 (95% CI: 19.91-33.75) bilaterally. The average number of SLNs removed was 1.6±0.8. The most common anatomical location of SLN was the right external iliac region. The SLN metastatic rate was 17%. Both sensitivity and negative predictive value regarding metastatic involvement were 100%.

Conclusion: The SLN detection rate, sensitivity and negative predictive value using Tc-99m-SENTI-SCINT in patients with EC in our study were high. The application of ultra-staging in the histopathological analysis of SLN increases the detection of nodal metastases and improves the staging in these patients.

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对子宫内膜癌一期患者使用放射性胶体进行前哨淋巴结活检的评估

目的：检测子宫内膜癌（EC）患者的前哨淋巴结（SLN）可降低不必要的全身淋巴清扫率。本研究旨在评估前哨淋巴结的检出率、使用 Tc-99m-SENTI-SCINT 方法的准确性以及术前一期 EC 患者的转移性结节受累率：方法：在宫颈应用4mCi Tc-99m-SENTI-SCINT后，对41例I期EC患者进行SLN活检的前瞻性研究。对中危患者进行平面淋巴管造影和盆腔单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT），如果半骨盆未检测到SLN，则对中危患者进行特定部位淋巴结切除术，对所有高危患者进行盆腔淋巴结切除术：术前平面淋巴管造影的检出率为 80.49 [95% 置信区间 (CI)：68.36-92.62]，SPECT/CT 的检出率为 95.12 (95% CI：88.52-101.7)。每位患者术中SLN总检出率为95.12（95% CI：88.52-101.7），双侧为26.83（95% CI：19.91-33.75）。切除的 SLN 平均数量为 1.6±0.8。SLN最常见的解剖位置是右侧髂外区域。SLN转移率为17%。结论：SLN检测率、敏感性和阴性预测值均为100%：结论：在我们的研究中，使用锝-99m-SENTI-SCINT对EC患者进行SLN检测的检出率、灵敏度和阴性预测值都很高。在 SLN 组织病理学分析中应用超分期技术可提高对结节转移的检出率，改善对这些患者的分期。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging and Radionuclide Therapy RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.30

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0.00%

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期刊介绍： Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.