Butyrate: More Than a Short Chain Fatty Acid.

IF 4.6 3区医学 Q1 NUTRITION & DIETETICS Current Nutrition Reports Pub Date : 2023-06-01 DOI:10.1007/s13668-023-00461-4

Osman Mohamed Elfadil, Manpreet S Mundi, Marwa G Abdelmagid, Ankitaben Patel, Nishant Patel, Robert Martindale

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引用次数: 3

Abstract

Purpose of review: The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus of microbiome understanding. This brief review aims to describe butyrate's relation to certain biological concepts and their clinical application.

Recent findings: Butyrate has reportedly been described as a potent pro-resolution molecule that has a significant role in maintaining gut immunity, supporting gut barrier function, regulation of histone deacetylase (HDAC), and numerous systemic roles. Further research is needed to explore potential benefits of adding SCFAs for patients receiving total parenteral nutrition. Butyrate plays several biological roles in intestinal epithelium anti-inflammatory pathways with clear benefits in numerous acute and chronic disease states and overall human health helping to maintain homeostasis.

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丁酸盐:不仅仅是一种短链脂肪酸。

综述的目的:对肠道微生物群的重要性和潜在益处的机制理解已经在人类健康和疾病的潜在作用中爆发。短链脂肪酸(SCFAs)，包括丁酸盐，是一个关键的代谢终产物，一直是主要的焦点微生物组的理解。本文简要介绍丁酸盐与某些生物学概念的关系及其临床应用。最近的发现:据报道，丁酸盐是一种有效的促分解分子，在维持肠道免疫、支持肠道屏障功能、调节组蛋白去乙酰化酶(HDAC)和许多系统作用方面具有重要作用。对于接受全肠外营养的患者，添加scfa的潜在益处需要进一步的研究。丁酸盐在肠上皮抗炎途径中发挥多种生物学作用，对许多急慢性疾病状态和整体人体健康有明显益处，有助于维持体内平衡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Nutrition Reports Agricultural and Biological Sciences-Food Science

CiteScore

7.70

自引率

2.00%

发文量

期刊介绍： This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.