Microfluidic Point-of-Care Diagnostics for Multi-Disease Detection Using Optical Techniques: A Review

IF 3.7 4区 生物学 Q1 BIOCHEMICAL RESEARCH METHODS IEEE Transactions on NanoBioscience Pub Date : 2023-07-03 DOI:10.1109/TNB.2023.3291544
Shaik Ahmadsaidulu;Oindrila Banik;Prasoon Kumar;Santosh Kumar;Earu Banoth
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Abstract

The lifestyle of modern society is a major contributing factor for the majority of patients suffering from more than one disease. To Screen and diagnose each of those diseases, there is a great need for portable, and economical diagnostic tools, which are highly stipulated to yield rapid and accurate results using a small volume of the samples such as blood, saliva, sweat, etc. Point-of-care Testing (POCT) is one of the approaches to harvest prompt diagnosis of numerous diseases. The Majority of Point-of-Care Devices (POCD) are developed to diagnose one disease within the specimen. On the other hand, multi-disease detection capabilities in the same point-of-care devices are considered to be an efficient candidate to execute the state-of-the-art platform for multi-disease detection. Most of the literature reviews in this field focus on Point-of-Care (POC) devices, their underlying principles of operation, and their potential applications. It is evident from a perusal of the scholarly works that no review articles have been written on multi-disease detection POC devices. A review study analyzing the current level and functionality of multi-disease detection POC devices would be of great use to future researchers and device manufacturers. This review paper is addressing the above gap by focusing on various optical techniques like fluorescence, Absorbance, and Surface Plasmon Resonance (SPR) for multi-disease detection by harnessing the microfluidic-based POC device.
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利用光学技术进行多种疾病检测的微流控医疗点诊断:综述。
现代社会的生活方式是导致大多数患者罹患一种以上疾病的主要因素。为了筛查和诊断每一种疾病,我们亟需便携、经济的诊断工具,这些工具只需少量样本,如血液、唾液、汗液等,就能快速、准确地得出结果。床旁检测(POCT)是迅速诊断多种疾病的方法之一。大多数护理点设备(POCD)是为诊断标本中的一种疾病而开发的。另一方面,同一护理点设备的多疾病检测功能被认为是执行多疾病检测先进平台的有效候选方案。该领域的大多数文献综述都侧重于护理点(POC)设备、其基本工作原理及其潜在应用。从学术著作中可以明显看出,还没有关于多疾病检测 POC 设备的综述文章。对多种疾病检测 POC 设备的现有水平和功能进行综述分析,对未来的研究人员和设备制造商大有裨益。本综述论文针对上述空白,重点介绍了利用微流体 POC 设备进行多种疾病检测的各种光学技术,如荧光、吸光和表面等离子体共振 (SPR)。
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来源期刊
IEEE Transactions on NanoBioscience
IEEE Transactions on NanoBioscience 工程技术-纳米科技
CiteScore
7.00
自引率
5.10%
发文量
197
审稿时长
>12 weeks
期刊介绍: The IEEE Transactions on NanoBioscience reports on original, innovative and interdisciplinary work on all aspects of molecular systems, cellular systems, and tissues (including molecular electronics). Topics covered in the journal focus on a broad spectrum of aspects, both on foundations and on applications. Specifically, methods and techniques, experimental aspects, design and implementation, instrumentation and laboratory equipment, clinical aspects, hardware and software data acquisition and analysis and computer based modelling are covered (based on traditional or high performance computing - parallel computers or computer networks).
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