The elusive role of myostatin signaling for muscle regeneration and maintenance of muscle and bone homeostasis

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM Osteoporosis and Sarcopenia Pub Date : 2023-03-01 DOI:10.1016/j.afos.2023.03.008
Akash Mitra , Rizwan Qaisar , Bipasha Bose , Sudheer Shenoy P
{"title":"The elusive role of myostatin signaling for muscle regeneration and maintenance of muscle and bone homeostasis","authors":"Akash Mitra ,&nbsp;Rizwan Qaisar ,&nbsp;Bipasha Bose ,&nbsp;Sudheer Shenoy P","doi":"10.1016/j.afos.2023.03.008","DOIUrl":null,"url":null,"abstract":"<div><p>Skeletal muscle is one of the leading frameworks of the musculo-skeletal system, which works in synergy with the bones. Long skeletal muscles provide stability and mobility to the human body and are primarily composed of proteins. Conversely, improper functioning of various skeletal muscles leads to diseases and disorders, namely, age-related muscle disorder called sarcopenia, a group of genetic muscle disorders such as muscular dystrophies, and severe muscle wasting in cancer known as cachexia. However, skeletal muscle has an excellent ability to undergo hypertrophy and enhanced functioning during sustained exercise over time. Indeed, these processes of skeletal muscle regeneration/hypertrophy, as well as degeneration and atrophy, involve an interplay of various signaling pathways. Myostatin is one such chemokine/myokine with a significant contribution to muscle regeneration or atrophy in multiple conditions. In this review, we try to put together the role and regulation of myostatin as a function of muscle regeneration extrapolated to multiple aspects of its molecular functions.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 1","pages":"Pages 1-7"},"PeriodicalIF":2.5000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111947/pdf/main.pdf","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Osteoporosis and Sarcopenia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405525523000092","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 2

Abstract

Skeletal muscle is one of the leading frameworks of the musculo-skeletal system, which works in synergy with the bones. Long skeletal muscles provide stability and mobility to the human body and are primarily composed of proteins. Conversely, improper functioning of various skeletal muscles leads to diseases and disorders, namely, age-related muscle disorder called sarcopenia, a group of genetic muscle disorders such as muscular dystrophies, and severe muscle wasting in cancer known as cachexia. However, skeletal muscle has an excellent ability to undergo hypertrophy and enhanced functioning during sustained exercise over time. Indeed, these processes of skeletal muscle regeneration/hypertrophy, as well as degeneration and atrophy, involve an interplay of various signaling pathways. Myostatin is one such chemokine/myokine with a significant contribution to muscle regeneration or atrophy in multiple conditions. In this review, we try to put together the role and regulation of myostatin as a function of muscle regeneration extrapolated to multiple aspects of its molecular functions.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
肌生长抑制素信号在肌肉再生和维持肌肉和骨骼稳态中的作用
骨骼肌是肌肉骨骼系统的主要框架之一,与骨骼协同工作。长骨骼肌为人体提供稳定性和灵活性,主要由蛋白质组成。相反,各种骨骼肌的功能失调会导致疾病和病症,即称为少肌症的年龄相关肌肉疾病、一组遗传性肌肉疾病,如肌肉营养不良,以及癌症中称为恶病质的严重肌肉萎缩。然而,随着时间的推移,骨骼肌具有极好的肥大能力,并在持续运动中增强功能。事实上,骨骼肌再生/肥大以及变性和萎缩的这些过程涉及各种信号通路的相互作用。肌抑制素是一种在多种情况下对肌肉再生或萎缩有显著贡献的趋化因子/肌因子。在这篇综述中,我们试图将肌生长抑制素作为肌肉再生功能的作用和调节归纳到其分子功能的多个方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Osteoporosis and Sarcopenia
Osteoporosis and Sarcopenia Orthopedics, Sports Medicine and Rehabilitation, Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Geriatrics and Gerontology
自引率
5.00%
发文量
23
审稿时长
66 days
期刊最新文献
Does intradiscal steroid injection accelerate the histological degeneration of the human disc? Surgery for spinal deformity with osteoporosis: Achieving successful fusion Verification of grip strength as an evaluation tool for locomotive syndrome in rheumatoid arthritis Effects of whole-body vibration on bone properties in type 2 diabetes model rats Choice of cemented or uncemented stems for displaced femoral neck fractures
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1