Connectivity between Gut Microbiota and Terminal Awakenings in Alzheimer's Disease.

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Current Alzheimer research Pub Date : 2023-01-01 DOI:10.2174/1567205020666230504153407
Mehmet Bostancıklıoğlu
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Abstract

Memory is empirically described as a brain function that connects the past to the present. This reductionist approach has focused on memory function within neurons and synapses, leading to an understanding that memory loss in dementia is caused by irreversible neuronal damage. However, recent palliative case reports and the Human Connectome Project have challenged the "irreversible" paradigm by indicating that some demented patients are able to retrieve supposed 'lost' memories and cognitive functions near death. The serotonin-centric hypothesis and the lifelong oligodendrocyte differentiation capacity may explain terminal awakening symptoms in these patients. Furthermore, an increased rate of serotonin-secreting and oligodendrocyte precursor cell-triggering gut bacteria near death temporally correlates with lucid improvements in demented patients. These findings may shift the context of terminal memory retrieval from a purely neuronal to a systemic idea that bridges terminal lucidity and gut microbiota. In this review, we take the systemic approach further and point out a temporal correlation between the gut microbiome and terminal lucid episodes in Alzheimer's patients.

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肠道微生物群与阿尔茨海默病终末觉醒之间的连通性。
根据经验,记忆被描述为一种连接过去和现在的大脑功能。这种还原论的方法专注于神经元和突触内的记忆功能,导致人们理解痴呆症中的记忆丧失是由不可逆的神经元损伤引起的。然而,最近的姑息治疗病例报告和人类连接组项目对“不可逆转”的范式提出了挑战,表明一些痴呆患者能够在临死前恢复所谓的“失去”的记忆和认知功能。以血清素为中心的假说和终生少突胶质细胞分化能力可以解释这些患者的晚期觉醒症状。此外,增加的血清素分泌率和少突胶质前体细胞触发的肠道细菌接近死亡与痴呆患者的清醒改善暂时相关。这些发现可能会将终端记忆检索的背景从纯粹的神经元转变为连接终端清醒和肠道微生物群的系统概念。在这篇综述中,我们进一步采用系统方法,并指出肠道微生物组与阿尔茨海默病患者晚期清醒发作之间的时间相关性。
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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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