Clearing Your Mind: Mechanisms of Debris Clearance After Cell Death During Neural Development.

IF 12.1 1区 医学 Q1 NEUROSCIENCES Annual review of neuroscience Pub Date : 2022-07-08 DOI:10.1146/annurev-neuro-110920-022431
Kendra E Liu, Michael H Raymond, Kodi S Ravichandran, Sarah Kucenas
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引用次数: 2

Abstract

Neurodevelopment and efferocytosis have fascinated scientists for decades. How an organism builds a nervous system that is precisely tuned for efficient behaviors and survival and how it simultaneously manages constant somatic cell turnover are complex questions that have resulted in distinct fields of study. Although neurodevelopment requires the overproduction of cells that are subsequently pruned back, very few studies marry these fields to elucidate the cellular and molecular mechanisms that drive nervous system development through the lens of cell clearance. In this review, we discuss these fields to highlight exciting areas of future synergy. We first review neurodevelopment from the perspective of overproduction and subsequent refinement and then discuss who clears this developmental debris and the mechanisms that control these events. We then end with how a more deliberate merger ofneurodevelopment and efferocytosis could reframe our understanding of homeostasis and disease and discuss areas of future study.

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清除你的头脑:神经发育过程中细胞死亡后碎片清除机制。
几十年来,神经发育和efferocytosis一直吸引着科学家。生物体是如何建立一个精确调节高效行为和生存的神经系统,以及它如何同时管理不断的体细胞更新,这些复杂的问题已经导致了不同的研究领域。尽管神经发育需要细胞的过度生产,这些细胞随后被修剪,但很少有研究结合这些领域来阐明通过细胞清除透镜驱动神经系统发育的细胞和分子机制。在本文中,我们将讨论这些领域,以突出未来协同作用的令人兴奋的领域。我们首先从过度生产和随后的细化的角度回顾神经发育,然后讨论谁清除这些发育碎片和控制这些事件的机制。最后,我们讨论了神经发育和efferocytosis的合并如何重新构建我们对体内平衡和疾病的理解,并讨论了未来的研究领域。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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