Impact of aging on immune function in the pathogenesis of pulmonary diseases: potential for therapeutic targets.

IF 2.9 3区医学 Q2 RESPIRATORY SYSTEM Expert Review of Respiratory Medicine Pub Date : 2023-05-01 Epub Date: 2023-04-26 DOI:10.1080/17476348.2023.2205127

Sadiya Bi Shaikh, Chiara Goracci, Ariel Tjitropranoto, Irfan Rahman

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Abstract

Introduction: Several immunological alterations that occur during pulmonary diseases often mimic alterations observed in the aged lung. From the molecular perspective, pulmonary diseases and aging partake in familiar mechanisms associated with significant dysregulation of the immune systems. Here, we summarized the findings of how aging alters immunity to respiratory conditions to identify age-impacted pathways and mechanisms that contribute to the development of pulmonary diseases.

Areas covered: The current review examines the impact of age-related molecular alterations in the aged immune system during various lung diseases, such as COPD, IPF, Asthma, and alongside many others that could possibly improve on current therapeutic interventions. Moreover, our increased understanding of this phenomenon may play a primary role in shaping immunomodulatory strategies to boost outcomes in the elderly. Here, the authors present new insights into the context of lung-related diseases and describe the alterations in the functioning of immune cells during various pulmonary conditions altered with age.

Expert opinion: The expert opinion provided the concepts on how aging alters immunity during pulmonary conditions, and suggests the associated mechanisms during the development of lung diseases. As a result, it becomes important to comprehend the complex mechanism of aging in the immune lung system.

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衰老对肺部疾病发病机制中免疫功能的影响：潜在的治疗目标。

前言在肺部疾病期间发生的一些免疫学改变往往与在老年肺部观察到的改变相似。从分子角度来看，肺部疾病和衰老都与免疫系统严重失调有关。在此，我们总结了衰老如何改变呼吸系统疾病免疫力的研究结果，以确定受年龄影响的途径和机制，这些途径和机制有助于肺部疾病的发展：本综述探讨了在慢性阻塞性肺疾病、IPF、哮喘等各种肺部疾病中，与年龄相关的分子改变对老年免疫系统的影响，以及可能改善当前治疗干预措施的其他因素。此外，我们对这一现象的进一步了解可能会在制定免疫调节策略以提高老年人的治疗效果方面发挥重要作用。在此，作者提出了对肺部相关疾病的新见解，并描述了在各种肺部疾病中，免疫细胞的功能随着年龄的增长而发生的变化：专家意见：该专家意见提供了关于衰老如何在肺部疾病期间改变免疫力的概念，并提出了肺部疾病发生的相关机制。因此，理解肺部免疫系统衰老的复杂机制变得非常重要。

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来源期刊

Expert Review of Respiratory Medicine RESPIRATORY SYSTEM-

CiteScore

6.80

自引率

2.60%

发文量

期刊介绍： Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity

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