Non-canonical Wnt signaling in the eye

IF 18.6 1区医学 Q1 OPHTHALMOLOGY Progress in Retinal and Eye Research Pub Date : 2023-07-01 DOI:10.1016/j.preteyeres.2022.101149

Ruchi Shah , Cynthia Amador , Steven T. Chun , Sean Ghiam , Mehrnoosh Saghizadeh , Andrei A. Kramerov , Alexander V. Ljubimov

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引用次数: 4

Abstract

Wnt signaling comprises a group of complex signal transduction pathways that play critical roles in cell proliferation, differentiation, and apoptosis during development, as well as in stem cell maintenance and adult tissue homeostasis. Wnt pathways are classified into two major groups, canonical (β-catenin-dependent) or non-canonical (β-catenin-independent). Most previous studies in the eye have focused on canonical Wnt signaling, and the role of non-canonical signaling remains poorly understood. Additionally, the crosstalk between canonical and non-canonical Wnt signaling in the eye has hardly been explored. In this review, we present an overview of available data on ocular non-canonical Wnt signaling, including developmental and functional aspects in different eye compartments. We also discuss important changes of this signaling in various ocular conditions, such as keratoconus, aniridia-related keratopathy, diabetes, age-related macular degeneration, optic nerve damage, pathological angiogenesis, and abnormalities in the trabecular meshwork and conjunctival cells, and limbal stem cell deficiency.

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眼睛中的非规范Wnt信号

Wnt信号包括一组复杂的信号转导通路，在细胞增殖、分化和发育过程中凋亡，以及干细胞维持和成体组织稳态中发挥关键作用。Wnt通路分为两大类，典型(β-catenin依赖)和非典型(β-catenin独立)。大多数先前的眼睛研究都集中在典型的Wnt信号上，而非典型信号的作用仍然知之甚少。此外，眼睛中规范和非规范Wnt信号之间的串扰几乎没有被探索过。在这篇综述中，我们概述了眼部非典型Wnt信号的现有数据，包括不同眼隔间的发育和功能方面。我们还讨论了该信号在各种眼部疾病中的重要变化，如圆锥角膜、无虹膜相关性角膜病变、糖尿病、年龄相关性黄斑变性、视神经损伤、病理性血管生成、小梁网和结膜细胞异常以及角膜缘干细胞缺乏。

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来源期刊

Progress in Retinal and Eye Research 医学-眼科学

CiteScore

34.10

自引率

5.10%

发文量

期刊介绍： Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.

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