Responder Analyses: A Methodological Mess.

IF 6 1区 医学 Q1 ORTHOPEDICS Journal of Orthopaedic & Sports Physical Therapy Pub Date : 2023-11-01 DOI:10.2519/jospt.2023.11853
Chad E Cook, Geronimo Bejarano, Jennifer Reneker, Andrew D Vigotsky, Daniel L Riddle
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Abstract

SYNOPSIS: Responder analyses are methods for analyzing randomized controlled trials, which purport to identify individuals or subgroups of study participants who experienced a "clinically meaningful" improvement from a treatment. Unfortunately, responder analyses have numerous methodological shortcomings, which preclude inferences concerning individual response to treatments and, thus, adoption into clinical practice. In this Viewpoint, we summarize 2 major limitations of responder analyses: (1) their thresholds of success involve arbitrary criteria and (2) responder analyses do not capture true individual treatment effects. J Orthop Sports Phys Ther 2023;53(XX):1-3. Epub: 20 June 2023. doi:10.2519/jospt.2023.11853.

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响应者分析:方法论上的混乱。
摘要:应答者分析是一种分析随机对照试验的方法,旨在识别个体或研究参与者的亚组,他们从治疗中经历了“临床有意义”的改善。不幸的是,应答者分析有许多方法学上的缺陷,这妨碍了对个体治疗反应的推断,因此无法应用于临床实践。在这个观点中,我们总结了反应者分析的两个主要局限性:(1)它们的成功阈值涉及任意标准;(2)反应者分析没有捕捉到真实的个体治疗效果。[J]中华体育杂志,2013;33(2):1-3。Epub: 2023年6月20日。doi: 10.2519 / jospt.2023.11853。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.00
自引率
4.90%
发文量
101
审稿时长
6-12 weeks
期刊介绍: The Journal of Orthopaedic & Sports Physical Therapy® (JOSPT®) publishes scientifically rigorous, clinically relevant content for physical therapists and others in the health care community to advance musculoskeletal and sports-related practice globally. To this end, JOSPT features the latest evidence-based research and clinical cases in musculoskeletal health, injury, and rehabilitation, including physical therapy, orthopaedics, sports medicine, and biomechanics. With an impact factor of 3.090, JOSPT is among the highest ranked physical therapy journals in Clarivate Analytics''s Journal Citation Reports, Science Edition (2017). JOSPT stands eighth of 65 journals in the category of rehabilitation, twelfth of 77 journals in orthopedics, and fourteenth of 81 journals in sport sciences. JOSPT''s 5-year impact factor is 4.061.
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