Glucose uptake and distribution across the human skeleton using state-of-the-art total-body PET/CT.

IF 14.3 1区 医学 Q1 CELL & TISSUE ENGINEERING Bone Research Pub Date : 2023-07-06 DOI:10.1038/s41413-023-00268-7
Weizhao Lu, Yanhua Duan, Kun Li, Jianfeng Qiu, Zhaoping Cheng
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引用次数: 1

Abstract

A growing number of studies have demonstrated that the skeleton is an endocrine organ that is involved in glucose metabolism and plays a significant role in human glucose homeostasis. However, there is still a limited understanding of the in vivo glucose uptake and distribution across the human skeleton. To address this issue, we aimed to elucidate the detailed profile of glucose uptake across the skeleton using a total-body positron emission tomography (PET) scanner. A total of 41 healthy participants were recruited. Two of them received a 1-hour dynamic total-body 18F-fluorodeoxyglucose (18F-FDG) PET scan, and all of them received a 10-minute static total-body 18F-FDG PET scan. The net influx rate (Ki) and standardized uptake value normalized by lean body mass (SUL) were calculated as indicators of glucose uptake from the dynamic and static PET data, respectively. The results showed that the vertebrae, hip bone and skull had relatively high Ki and SUL values compared with metabolic organs such as the liver. Both the Ki and SUL were higher in the epiphyseal, metaphyseal and cortical regions of long bones. Moreover, trends associated with age and overweight with glucose uptake (SULmax and SULmean) in bones were uncovered. Overall, these results indicate that the skeleton is a site with significant glucose uptake, and skeletal glucose uptake can be affected by age and dysregulated metabolism.

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使用最先进的全身PET/CT研究人体骨骼的葡萄糖摄取和分布。
越来越多的研究表明,骨骼是参与葡萄糖代谢的内分泌器官,在人体葡萄糖稳态中起着重要作用。然而,对体内葡萄糖的摄取和在人体骨骼中的分布的了解仍然有限。为了解决这个问题,我们的目的是利用全身正电子发射断层扫描(PET)扫描仪阐明整个骨骼葡萄糖摄取的详细情况。总共招募了41名健康参与者。其中2例接受1小时动态全身18f -氟脱氧葡萄糖(18F-FDG) PET扫描,所有患者接受10分钟静态全身18F-FDG PET扫描。从动态和静态PET数据中分别计算净内流率(Ki)和瘦体重标准化摄取值(SUL)作为葡萄糖摄取的指标。结果表明,与肝脏等代谢器官相比,椎骨、髋骨和颅骨的Ki和SUL值相对较高。长骨骨骺区、干骺区和皮质区Ki和SUL均较高。此外,还发现了年龄和超重与骨骼中葡萄糖摄取(SULmax和SULmean)相关的趋势。总的来说,这些结果表明骨骼是一个重要的葡萄糖摄取部位,骨骼葡萄糖摄取可能受到年龄和代谢失调的影响。
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来源期刊
Bone Research
Bone Research CELL & TISSUE ENGINEERING-
CiteScore
20.00
自引率
4.70%
发文量
289
审稿时长
20 weeks
期刊介绍: Established in 2013, Bone Research is a newly-founded English-language periodical that centers on the basic and clinical facets of bone biology, pathophysiology, and regeneration. It is dedicated to championing key findings emerging from both basic investigations and clinical research concerning bone-related topics. The journal's objective is to globally disseminate research in bone-related physiology, pathology, diseases, and treatment, contributing to the advancement of knowledge in this field.
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