Factores asociados a sobrevida a un año en pacientes postoperados de glioblastoma.

Abstract

Objective: To identify factors associated with one-year survival in postoperative glioblastoma patients at a hospital in northeastern Mexico.

Material and methods: Nested case-control study. Patients operated on for glioblastoma between 2016-2019 were included. Information about clinical and surgical factors was obtained, survival was calculated by Kaplan-Meier analysis. Descriptive analysis was performed with medians and ranges, and inferential analysis with χ², Fisher and Student t test, odds ratio and 95% confidence interval. A value of p < 0.05 was considered significant.

Results: Sixty-two patients with glioblastoma were included, 27 (43.5%) women and 35 (56.5%) men, median age 56 years (range: 6-83). Median survival was 3.6 months (1-52), 45 (72.6%) survived less than 12 months. The factors associated with a higher survival were administration of adjuvant treatment (p < 0.001), better functional status (p = 0.001), and absence of post-surgical complications (p = 0.034).

Conclusions: Most patients with glioblastoma survive less than 12 months and the factors most strongly associated with longer survival are administration of adjuvant treatment, better functional status of the patient and absence of post-surgical complications.